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Kyungho Lee,Junseok Jeon,Jong Man Kim,Gaabsoo Kim,김경아,Hye Ryoun Jang,Jung Eun Lee,Jae-Won Joh,Suk-Koo Lee,Wooseong Huh 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.1
Purpose: The incidence of chronic kidney disease (CKD) has been increasing due to improved survival after liver transplantation (LT). Risk factors of kidney injury after LT, especially perioperative management factors, are potentially modifiable. We investigated the risk factors associated with progressive CKD for 10 years after LT. Methods: This retrospective cohort study included 292 adult patients who underwent LT at a tertiary referral hospital between 2000 and 2008. Renal function was assessed by the e stimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease formula. The area under the curve of serial eGFR (AUCeGFR) was calculated for each patient to assess the trajectory of eGFR over the 10 years. Low AUCeGFR was considered progressive CKD. Linear regression analyses were performed to examine the associations between the variables and AUCeGFR. Results: Multivariable analysis showed that older age (regression coefficient = -0.53, P < 0.001), diabetes mellitus (DM) (regression coefficient = -6.93, P = 0.007), preoperative proteinuria (regression coefficient = -16.11, P < 0.001), preoperative acute kidney injury (AKI) (regression coefficient = -14.35, P < 0.001), postoperative AKI (regression coefficient = -3.86, P = 0.007), and postoperative mean vasopressor score (regression coefficient = -0.45, P = 0.034) were independently associated with progressive CKD. Conclusion: More careful renoprotective management is required in elderly LT patients with DM or preexisting proteinuria. Postoperative AKI and vasopressor dose may be potentially modifiable risk factors for progressive CKD.
YOO, Kyungho,SUNG, Sangkyung,LEE, Eunsung,LEE, Sanguk,KIM, Jaehoon,LEE, Ho-Jin,LEE, Young Jae THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIEN 2009 Transactions of the Japan Society for Aeronautical Vol.52 No.177
<P>Today Global Navigation Satellite Systems (GNSS) are widely used for determining position. Within the city environment, however, in which there are many tall buildings, GNSS signals are frequently interrupted, making it difficult for users to obtain information on their exact position. This paper analyzed the availability and positioning performance of a GPS augmented system within the Seoul urban area using the Japanese QZSS (Quasi-Zenith Satellite System) and a geostationary satellite. A 3-dimensional reproduction of Seoul that was based on the 3D GIS (Geographic Information System) Digital Map and a satellite tracking algorithm using Ray-Triangle Intersection algorithm were discussed. A satellite tracking algorithm was verified through filed testing and the QZSS orbit simulator was realized using Keplerian parameter. DOP (Dilution of Precision) and availability in the urban area of Seoul were analyzed using a GPS/QZSS/geostationary satellite separately and simultaneously.</P>
Lee Sangho,Lee Han-Teo,Kim Young Ah,Lee Il-Hwan,Kang Seong-Jun,Sim Kyeongpyo,Park Chung-Gyu,Choi Kyungho,Youn Hong-Duk 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The C-terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells (NFAT). However, the specific sequences and mechanisms through which it binds to calcineurin are unclear. This study determined that decameric peptide (CABIN1 residues 2146–2155) is minimally required for binding to calcineurin. This peptide contains a unique “PPTP” C-terminal sequence and a “PxIxIT” N-terminal motif. Furthermore, p38MAPK phosphorylated the threonine residue of the “PPTP” sequence under physiological conditions, dramatically enhancing the peptide’s binding affinity to calcineurin. Therefore, the CABIN1 peptide inhibited the calcineurin-NFAT pathway and the activation of T cells more efficiently than the VIVIT peptide without affecting calcineurin’s phosphatase activity. The CABIN1 peptide could thus be a more potent calcineurin inhibitor and provide therapeutic opportunities for various diseases caused by the calcineurin-NFAT pathway.
Lee, Kyungho,Lee, Songhyun,Jun, Youngsun,Choi, Minkee Academic Press 2017 Journal of catalysis Vol.347 No.-
<P><B>Abstract</B></P> <P>The cooperative effects of secondary mesoporosity and defects on the coke formation and deactivation of zeolite were investigated in <I>n</I>-pentane aromatization using model Ga/ZSM-5 catalysts. Mesoporosity was introduced to a commercial ZSM-5 by alkaline desilication, while the defects sites (<I>i.e.</I>, internal silanols) in zeolites were annealed by the treatment with ammoniumhexafluorosilicate. Aromatization after supporting Ga showed that the mesopore generation retarded catalyst deactivation via the suppression of internal coke formation while facilitating the external coke formation due to the enhanced diffusion of coke precursors <I>(e.g</I>., alkylaromatics) out of zeolite micropores. Internal coke can cause a more severe deactivation than external coke because the acid sites are mainly located in the zeolite micropores. However, the mesopore generation alone could not efficiently reduce the total amount of coke deposition (it mainly changed the location of coke). In contrast, the annealing of internal silanols could suppress the overall coke formation. This phenomenon could be explained by the fact that coke precursors are initially generated at the zeolite internal defects, and then deposited as coke at either the internal or the external surfaces of the zeolite depending on the relative kinetics of coke precursor diffusion and its polymerization. Consequently, the catalyst with mesoporosity and annealed internal silanols exhibited the slowest catalyst deactivation due to the suppression of both internal and external coke depositions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of zeolite mesopore and internal defects on coke formation were studied. </LI> <LI> Mesopore mainly changes the location of coke deposition, not its overall quantity. </LI> <LI> Mesopore induces external coke deposition which is less harmful than internal coke. </LI> <LI> Annealing defects suppress coke formation by inhibiting coke precursor formation. </LI> <LI> Generating mesopore while minimizing defect is effective for retarding deactivation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Suggestions for the Estimation of the Methane Emission from a Landfill Site
Lee, Kyungho,Jeon, Eunjeong,Lee, Youngmin,Park, Junghyun Urban Science Institute 2020 도시과학 Vol.9 No.1
Sudokwon landfill("Sudokwon" means regions of Seoul, Kyunggi and Incheon metropolitan cities in Korea), the world's largest sanitary landfill, has been systematically managing statistics on the incoming and dumping wastes and satisfactorily controlling pollutants including leachate and LFG. According to our long time experience of LFG field monitoring, the emission of GHG from landfill estimated by the IPCC Guideline showed much difference with our results. C&D waste has high concentration of sulfate compared to other wastes. Increased C&D waste of dumping waste had changed the COD/sulfate ratio in the landfill, which caused the increase of H<sub>2</sub>S gas and the decrease of CH<sub>4</sub> gas. But the IPCC estimation method does not consider the effects of sulfate. In addition to that, the oxidation factor of the cover soil is set to the default values of 0.1 but the measured values by the field monitoring, are showing much higher than that, especially in the closed landfill.