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Yi, SoJeong,Cho, Joo-Youn,Lim, Kyoung Soo,Kim, Kyu-pyo,Kim, JaeWoo,Kim, Bo-Hyung,Hong, Jang-hee,Jang, In-Jin,Shin, Sang-Goo,Yu, Kyung-Sang Blackwell Publishing Ltd 2009 Basic & Clinical Pharmacology & Toxicology Vol.105 No.4
<P>Abstract: </P><P>Three kinds of herbal medicines, commonly used in Korea, <I>Angelicae tenuissima radix</I>, <I>Angelicae dahuricae radix</I> and <I>Scutellariae radix</I> were studied to evaluate their effect on cytochrome <I>P450</I> (CYP) activities in healthy volunteers. A total of 24 healthy male volunteers were assigned to one of three parallel herbal treatment groups, each consisting of eight volunteers. A cocktail of probe drugs for CYP enzymes was orally administered before and after multiple administrations of herbal medicines, three times a day for 13 days. Probe drugs used to measure CYP activities were caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4). The probe drugs and their metabolites were quantified in plasma or urine using HPLC or LC-MS/MS. Changes in each CYP activity was evaluated by metabolic ratio of the probe drug (concentration ratio of metabolite to parent form at reference time point) following the herbal medication period, compared to the baseline values. <I>A. dahuricae radix</I> significantly decreased CYP1A2 activity to 10% of baseline activity (95% CI: 0.05–0.21). <I>S. radix</I> also showed significant changes in CYP2C9 and CYP2E1 activities. Compared to baseline values, the metabolic activities of losartan were decreased to 71% (0.54–0.94). In addition, <I>S. radix</I> showed a 1.42-fold (1.03–1.97) increase in chlorzoxazone metabolic activity. However, CYP activities were not meaningfully influenced by <I>A. tenuissima radix</I>. Changes in certain CYP activities were observed after the administration of <I>S. radix</I> and <I>A. dahuricae radix</I> in healthy volunteers. Therefore, herbal medicines containing <I>S. radix</I> or <I>A. dahuricae radix</I> are candidates for further evaluation of clinically significant CYP-mediated herb-drug interactions in human beings.</P>
Surgical endodontic management of infected lateral canals of maxillary incisors
Jang, Ji-Hyun,Lee, Jung-Min,Yi, Jin-Kyu,Choi, Sung-Baik,Park, Sang-Hyuk The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.1
This case report presents surgical endodontic management outcomes of maxillary incisors that were infected via the lateral canals. Two cases are presented in which endodontically-treated maxillary central incisors had sustained lateral canal infections. A surgical endodontic treatment was performed on both teeth. Flap elevation revealed vertical bone destruction along the root surface and infected lateral canals, and microscopy revealed that the lateral canals were the origin of the lesions. After the infected lateral canals were surgically managed, both teeth were asymptomatic and labial fistulas were resolved. There were no clinical or radiographic signs of surgical endodontic management failure at follow-up visits. This case report highlights the clinical significance and surgical endodontic management of infected lateral canal of maxillary incisor. It is important to be aware of root canal anatomy variability in maxillary incisors. Maxillary central incisors infected via the lateral canal can be successfully managed by surgical endodontic treatment.
Yi-Kyu Kang,Hea-Gwang Jeong,Kyo-Beum Lee,Dong-Choon Lee,Jang-Mok Kim 전력전자학회 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.4
This paper presents simple schemes used to estimate the initial rotor position and the d- and q-axis inductances for effective Maximum Torque per Ampere (MTPA) operation in a wind-power system using an IPMSM (Interior Permanent Magnet Synchronous Machine). An IPMSM essentially requires an exact coordinate transformation and accurate inductance values to use a reluctance torque caused by the saliency characteristic. In the proposed high-frequency voltage testing method, there is no voltage drop caused by the resistance and the electromotive force. The initial rotor position and the inductance can be measured through an analysis of the stator current without turning the rotor. The experimental results are presented in order to illustrate the feasibility of the proposed method.
Effects of Fluorine Implantation on 1/f Noise, Hot Carrier and NBTI Reliability of MOSFETs
JANG, Jae-Hyung,KWON, Hyuk-Min,KWAK, Ho-Young,KWON, Sung-Kyu,HWANG, Seon-Man,SHIN, Jong-Kwan,SUNG, Seung-Yong,CHUNG, Yi-Sun,LEE, Da-Soon,LEE, Hi-Deok 'Institute of Electronics, Information and Communi 2013 IEICE transactions on electronics Vol.96 No.5
Yi, SoJeong,Kim, Sung Eun,Park, Min-Kyu,Yoon, Seo Hyun,Cho, Joo-Youn,Lim, Kyoung Soo,Shin, Sang-Goo,Jang, In-Jin,Yu, Kyung-Sang Adis International 2012 BioDrugs Vol.26 No.3
<P>HD203 is a biosimilar of etanercept, a fusion protein of the ligand-binding portion of the human tumor necrosis factor receptor II linked to the Fc portion of human immunoglobulin G1. Since HD203 is under clinical development, this study was conducted to compare the pharmacokinetics of HD203 with Enbrel®, the first marketed etanercept.</P>
장철섭,오승규,이원 한국공작기계학회 2005 한국생산제조학회지 Vol.14 No.2
This article has been investigated the use of FIT for adhesive joints analysis between metal sheets. The method is based on the measurement of the reflection wave at the metal/adhesive interface. After describing briefly the physical aspects of the phenomenon, an index is defined to detect defective zone of the joint(both for the lack of adhesive and for insufficient adhesion); the influence of the experimental variables(variable stress..,) on the measurement is discussed. By means of a control experiment it is shown that stress variation in adhesive joints are separate to be distinguished. In this paper, Nondestructive evaluation in adhesive joints are evaluated together with ultrasonic testing and finite element analysis.
Yi, Eun-Surk,Oh, Seikwan,Lee, Jang-kyu,Leem, Yea-Hyun Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Chronic stress is a precipitating factor for disorders including depression. The basolateral amygdala (BLA) is a critical substrate that interconnects with stress-modulated neural networks to generate emotion- and mood-related behaviors. The current study shows that 3 h per day of restraint stress for 14 days caused mice to exhibit long-term depressive behaviors, manifested by disrupted sociality and despair levels, which were rescued by fluoxetine. These behavioral changes corresponded with morphological and molecular changes in BLA neurons, including chronic stress-elicited increases in arborization, dendritic length, and spine density of BLA principal neurons. At the molecular level, calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (CP-AMPARs) within the synaptosome exhibited an increased GluR1:GluR2 subunit ratio. We also observed increased GluR1 phosphorylation at Ser 845 and enhanced cyclic AMP-dependent protein kinase (PKA) activity in the BLA. These molecular changes reverted to the basal state post-treatment with fluoxetine. The expression of synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95) at BLA neuronal synapses was also enhanced by chronic stress, which was reversed post-treatment. Finally, chronic stress-provoked depressive behavior was overcome by local blockage of CP-AMPARs in the BLA via stereotaxic injection (IEM-1460). Chronic stress-elicited depressive behavior may be due to hypertrophy of BLA neuronal dendrites and increased of PKA-dependent CP-AMPAR levels in BLA neurons. Furthermore, fluoxetine can reverse chronic stress-triggered cytoarchitectural and functional changes of BLA neurons. These findings provide insights into depression-linked structural and functional changes in BLA neurons.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Chronic stress causes behavioral depression, which is reversed by fluoxetine. </LI> <LI> Chronic stress causes the change of dendritic morphology of BLA neurons. </LI> <LI> Chronic stress increases synaptosomal PKA-dependent CP-AMPARs levels of BLA. </LI> <LI> Chronic stress-induced structural and molecular changes are reversed by fluoxetine. </LI> <LI> Blockage of CP-AMPARs in BLA mitigates stress-elicited depressive phenotype. </LI> </UL> </P>