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대단위 병렬컴퓨터 시스템 노드구조 설계를 위한 워크벤치(SKYLAB)의 개발
윤현진,육은정,노권형,황대준 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1
Building the simulation environment of massively parallel computer systems has been recognized as a better approach over the experimentation on real machines to study extensively their architectural behaviours at a minimum cost. In this paper, we introduce a parallel processing workbench SKYLAB being implemented on DE C5000/25 and SPARCI workstations for design of node architectures featuring optimal organization for massively parallel processing. For the through analysis of the features of architectures in mind, the SKYLAB comes with thress major components: the compilerbackend translating single-threaded codes into their equivalent multithreaded codes, the node architecture emulator incopperating target CPU for program execution, and the graphic use interface for easy interpretation and expedating the analysis of the statitistics from the simulation runs. The design experience of the node architecture of the DAVRID multithreaded parallel processing computer using the SKYLAB examplifies how much effictively to make experiment on parallel simulations using this integrated toolset.
Enhanced Th2 cell differentiation and function in the absence of Nox2
Kwon, B. I.,Kim, T. W.,Shin, K.,Kim, Y. H.,Yuk, C. M.,Yuk, J. M.,Shin, D. M.,Jo, E. K.,Lee, C. H.,Lee, S. H. John Wiley Sons Ltd 2017 Allergy Vol.72 No.2
<P>Conclusion: Our findings indicate that Nox2 deficiency results in exaggerated experimental asthma, which is caused by enhanced Th2 effector function in a T-cell-intrinsic manner.</P>
Reassortant Clade 2.3.4.4 Avian Influenza A(H5N6) Virus in a Wild Mandarin Duck, South Korea, 2016
Kwon, Jung-Hoon,Lee, Dong-Hun,Swayne, David E.,Noh, Jin-Yong,Yuk, Seong-Su,Erdene-Ochir, Tseren-Ochir,Hong, Woo-Tack,Jeong, Jei-Hyun,Jeong, Sol,Gwon, Gyeong-Bin,Lee, Seok,Song, Chang-Seon U.S. Department of Health and Human Services * Cen 2017 Emerging Infectious Diseases Vol.23 No.5
<P>A reassortant clade 2.3.4.4 avian influenza A(H5N6) virus was isolated from a fecal sample of a Mandarin duck (<I>Aix galericulata</I>) in South Korea during October 2016. This virus was genetically similar to H5N6 subtype virus isolates from China, Vietnam, Laos, and Hong Kong, including human isolates.</P>
Kwon, Jung-Hoon,Noh, Yun Kyung,Lee, Dong-Hun,Yuk, Seong-Su,Erdene-Ochir, Tseren-Ochir,Noh, Jin-Yong,Hong, Woo-Tack,Jeong, Jei-Hyun,Jeong, Sol,Gwon, Gyeong-Bin,Song, Chang-Seon,Nahm, Sang-Soep Elsevier 2017 Veterinary microbiology Vol.203 No.-
<P><B>Abstract</B></P> <P>Wild birds play a major role in the evolution, maintenance, and dissemination of highly pathogenic avian influenza viruses (HPAIV). Sub-clinical infection with HPAI in resident wild birds could be a source of dissemination of HPAIV and continuous outbreaks. In this study, the pathogenicity and infectivity of two strains of H5N8 clade 2.3.4.4 virus were evaluated in the Mandarin duck (<I>Aix galericulata</I>) and domestic pigeon (<I>Columba livia domestica</I>). None of the birds experimentally infected with H5N8 viruses showed clinical signs or mortality. The H5N8 viruses efficiently replicated in the virus-inoculated Mandarin ducks and transmitted to co-housed Mandarin ducks. Although relatively high levels of viral shedding were noted in pigeons, viral shedding was not detected in some of the pigeons and the shedding period was relatively short. Furthermore, the infection was not transmitted to co-housed pigeons. Immunohistochemical examination revealed the presence of HPAIV in multiple organs of the infected birds. Histopathological evaluation showed the presence of inflammatory responses primarily in HPAIV-positive organs. Our results indicate that Mandarin ducks and pigeons can be infected with H5N8 HPAIV without exhibiting clinical signs; thus, they may be potential healthy reservoirs of the H5N8 HPAIV.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mandarin ducks and pigeons can be infected with H5N8 HPAI viruses without exhibiting clinical signs. </LI> <LI> The titer of excreted virus was relatively high in a Mandarin duck and was detected in multiple organs. </LI> <LI> Mandarin ducks and pigeons may be potential healthy reservoirs of the H5N8 HPAI virus. </LI> </UL> </P>
Yuk, S.s.,Erdene-Ochir, T.O.,Kwon, J.H.,Noh, J.Y.,Hong, W.t.,Jeong, J.H.,Jeong, S.,Gwon, G.B.,Shin, J.i.,Sur, J.H.,Song, C.S. Butterworths ; Elsevier Science Ltd 2017 Vaccine Vol.35 No.9
Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.
Yuk, Soon Hong,Oh, Keun Sang,Cho, Sun Hang,Lee, Beom Suk,Kim, Sang Yoon,Kwak, Byung-Kook,Kim, Kwangmeyung,Kwon, Ick Chan American Chemical Society 2011 Biomacromolecules Vol.12 No.6
<P>We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin network to form the composite NPs. To induce the ionic interaction between the iron oxide nanoseeds and glycol chitosan, gold was deposited on the surface of iron oxide nanoseeds. After the immobilization of gold-deposited iron oxide NPs into the glycol chitosan network, the NPs were stabilized with heparin based on the ionic interaction between cationic glycol chitosan and anionic heparin. FE-SEM (field emission-scanning electron microscopy) and a particle size analyzer were used to observe the formation of the stabilized composite NPs, and a Jobin-Yvon Ultima-C inductively coupled plasma-atomic emission spectrometer (ICP-AES) was used to measure the contents (%) of formed iron oxide nanoseeds as a function of reaction temperature and formed gold deposited on the iron oxide nanoparticles. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor-targeting ability of the composite NPs using a noninvasive NIR fluorescence imaging technology. To observe the MRI contrast characteristic, the composite NPs were injected into the tail veins of tumor-bearing mice to demonstrate their selective tumoral distribution. The MR images were collected with conventional T<SUB>2</SUB>-weighted spin echo acquisition parameters.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-6/bm200413a/production/images/medium/bm-2011-00413a_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm200413a'>ACS Electronic Supporting Info</A></P>
Kwon, Jung-Hoon,Noh, Jin-Yong,Jeong, Jei-Hyun,Jeong, Sol,Lee, Sun-Hak,Kim, Yu-Jin,Yuk, Seong-Su,Lee, Dong-Hun,Bae, You-Chan,Park, Seok-Chan,Lee, Kyung-Hyun,Lee, Eun-Kyoung,Lee, Yu-Na,Lee, Youn-Jeong,S 3M Company 2019 Virology Vol.530 No.-
<P><B>Abstract</B></P> <P>H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The two genotypes of H5N6 HPAI viruses showed different pathogenicity in ducks. </LI> <LI> The C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. </LI> <LI> The reassortment of HPAIVs could effect on the pathogenicity in ducks. </LI> </UL> </P>
Kwon, Eun-Bin,Kang, Myung-Ji,Kim, Soo-Yeon,Lee, Yong-Moon,Lee, Mi-Kyeong,Yuk, Heung Joo,Ryu, Hyung Won,Lee, Su Ui,Oh, Sei-Ryang,Moon, Dong-Oh,Lee, Hyun-Sun,Kim, Mun-Ock Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><I>Zanthoxylum ailanthoides</I> (ZA) has been used as folk medicines in East Asian and recently reported to have several bioactivity; however, the studies of ZA on the regulation of triacylglycerol (TG) biosynthesis have not been elucidated yet. In this study, we examined whether the methanol extract of ZA (ZA-M) could reduce oleic acid- (OA-) induced intracellular lipid accumulation and confirmed its mode of action in HepG2 cells. ZA-M was shown to promote the phosphorylation of AMPK and its upstream LKB1, followed by reduction of lipogenic gene expressions. As a result, treatment of ZA-M blocked de novo TG biosynthesis and subsequently mitigated intracellular neutral lipid accumulation in HepG2 cells. ZA-M also inhibited OA-induced production of reactive oxygen species (ROS) and TNF-<I>α</I>, suggesting that ZA-M possess the anti-inflammatory feature in fatty acid over accumulated condition. Taken together, these results suggest that ZA-M attenuates OA-induced lipid accumulation and inflammation through the activation of LKB1/AMPK signaling pathway in HepG2 cells.</P>
Yuk, S.s.,Kwon, J.H.,Noh, J.Y.,Hong, W.t.,Gwon, G.B.,Jeong, J.H.,Jeong, S.,Youn, H.N.,Heo, Y.H.,Lee, J.B.,Park, S.Y.,Choi, I.S.,Song, C.S. Elsevier/North-Holland Biomedical Press 2016 JOURNAL OF VIROLOGICAL METHODS Vol.230 No.-
A sensitive and specific method for measuring the vaccine titer of infectious bronchitis virus (IBV) is important to commercial manufacturers for improving vaccine quality. Typically, IBV is titrated in embryonated chicken eggs, and the infectivity of the virus dilutions is determined by assessing clinical signs in the embryos as evidence of viral propagation. In this study, we used a dot-immunoblotting assay (DIA) to measure the titers of IBV vaccines that originated from different pathogenic strains or attenuation methods in embryonated eggs, and we compared this assay to the currently used method, clinical sign evaluation. To compare the two methods, we used real-time reverse transcription-PCR, which had the lowest limit of detection for propagated IBV. As a clinical sign of infection, dwarfism of the embryo was quantified using the embryo: egg (EE) index. The DIA showed 9.41% higher sensitivity and 15.5% higher specificity than the clinical sign determination method. The DIA was particularly useful for measuring the titer of IBV vaccine that did not cause apparent stunting but propagated in embryonated chicken eggs such as a heat-adapted vaccine strain. The results of this study indicate that the DIA is a rapid, sensitive, reliable method for determining IBV vaccine titer in embryonated eggs at a relatively low cost.