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강보승,이정훈,송형곤,송근정,정연권 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3
Heat stroke, a medical emergency, occurs when the body's thermal regulation is upset and unable to dissipate adequate amounts of heat with a rise in body temperature. It is characterized by hyperpyrexia, with a core temperature of 40˚C or more. hot dry skin, and central nervous system disturbance and usually results in rhabdomyolysis and multiorgan failure. Our case, a 43-year-old healthy male, was caused by a marathon, half course, on a sunny day in late summer. He suddenly fell down on the road and was delivered to a nearby hospital, where a seizure developed. He was transfered to our hospital and then displayed Central Nervous System disturbance, hot dry skin, acute liver failure, rhabdomyolysis, anurlc acute renal failure, and disseminated intravasculular coagulopathy. He was treated with general supportive care and hemofiltration. Despite the aggressive management, he died of shock on the fifth day after admission.
神經精神科 疾患과 關聯된 醫案의 硏究 : 中國 宋ㆍ金ㆍ元ㆍ明 時代 醫案을 中心으로
權保亨,具炳壽 대한한방신경정신과학회 1997 동의신경정신과학회지 Vol.8 No.1
according to study of clinical document in relation to Neuropsychiatric disease in Ancient Chinese(Song, Keum, Won, Myung) clinical document the result were obtained as follows. 1. A main point is Jeul-Jin<切診> in diagnosis, that is Hyun-Maeg<弦脈> is liver disease, Whual Mag<滑脈> is gallbladder disease, Sag Mag<數脈> is fever. 2. Doctors in Song<宋>, Keum<金>,Won<元> enumerationed many diseases are cause by emotion. 3. Oriental psychotherapy that Diseases caused by surprising must be cure by surprising is like to systematic desensitization in Westem. 4. Oriental psychotherapy that pseudopsychosis must be cure by patient rely on doctor is like to suggestive therapy in western. 5. It is similar to suggestive therapy in western medicine that Sadness ,anguish and frustration induce disease. 6. Headache is caused by fever, energy deficience and angry. 7. Imsomnia is not caused by hsart disease, but gallbladder or liver. 8. Schizophrenia is caused by shocking and a sort of fever. 9. Epilepsy is caused by a sort of fever, shocking and fetal disease. 10 Schizophrenia(in case of manic state) is caused by fever and shocking, and imaginary pregnancy is considered as schizophrenia.
( Hyung-joo Oh ),( In-jae Oh ),( Min-seok Kim ),( Bo-gun Kho ),( Chul-kyu Park ),( Young-chul Kim ),( Ha-young Park ),( Tae-ok Kim ),( Hong-joon Shin ),( Yong-soo Kwon ),( Yu-il Kim ),( Sung-chul Lim 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Lorlatinib is a third generation ALK or ROS1 tyrosine kinase inhibitor (TKI) to treat TKI refractory non-small-cell lung cancer (NSCLC). We report efficacy and safety of lorlatinib in patients previously treated with first or second generation ALK-TKIs. Methods Advanced NSCLC patients who initiated lorlatinib between April 2018 and January 2020 were retrospectively analyzed in a single institution. Results A total of 14 patients were included and the median age was 62.5 years (range, 40-79). All patients were ALK-positive NSCLC and had been treated with more than two ALK-TKIs previously. Excluding one patient who expired before response evaluation, 5 experienced partial response (objective response rate: 35.7%), and 6 had stable disease (disease control rate: 78.6%). The median duration of treatment was 7.5 months (range, 0.6-23.9) and the median progression-free survival was 7.7 months (range, 1.1-22.3). Among six patients who had brain metastasis, two had partial response and other two had stable disease. Among 2 cases that underwent next generation sequencing before loratinib, G1202R mutation was founded in one patients as an on-target resistance mechanism after alectinib. The most common adverse event was hypercholesterolemia (76.9%). In most patients (80%), total cholesterol rose to the highest level within the 2 months after lorlatinib and it could be controlled by lipid-lowering agents. Conclusions Lorlatinib could be a novel therapeutic option for patients with ALK-positive advanced NSCLC whose disease progressed after first and second generation TKIs. Hypercholesterolemia was manageable common adverse event.
( Bo Mi Choi ),( Seong Wan Son ),( Chan Kwon Park ),( Sang Hoon Lee ),( Hyung Kyu Yoon ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3
Lemierre syndrome (LS) is a septic thrombophlebitis of the internal jugular vein (IJV) following an oropharyngeal infection. LS is commonly caused by normal anaerobic flora and treated with appropriate antibiotics and anticoagulation therapy. Although the incidence of disease is very rare, 15% cases of LS are fatal even in the antibiotic era because of disseminated septic thromboemboli. We reported a case of extensive bilateral LS due to methicillin-resistant Staphylococcus epidermidis in a 63-year-old female with lung adenocarcinoma. Initial examination revealed a retropharyngeal abscess; hence, intravenous ceftriaxone and steroid were initiated empirically. However, pulmonary thromboembolism developed and methicillin-resistant S. epidermidis was identified in the bacterial culture. Despite intensive antibiotic and anticoagulation therapies, extensive septic thrombophlebitis involving the bilateral IJV and superior vena cava developed. Adjunctive catheter-directed thrombolysis and superior vena cava stenting were performed and the patient received antibiotic therapy for an additional 4 weeks, resulting in complete recovery.