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보여주고 들려주는 붓다 고사 ― 돈황본 <八相變>의 공연 방식과 필사본 제작
鄭廣薰 ( Jung¸ Kwanghun ) 중국어문연구회 2021 中國語文論叢 Vol.- No.107
Baxiang bian 八相變is a Dunhuang bianwen 敦煌變文based on the Baxiang story of Buddha. A Baxiang story consists of eight stages, from the Buddha’s birth to his death. Since the ‘xiang’ 相of ‘Baxiang’ can be said to be a kind of scene, it is closely related to Buddhist paintings, similar to the ‘xiang’ in ‘bianxiang’ 變相. The relevance of this term to painting is one of the characteristics of the typical Dunhuang bianwen works, so this paper will analyze the characteristics of Baxiang bian from the perspective of pictorial storytelling. One of the important elements in the pictorial storytelling of bianwen is the use of a verse-introductory formula. This formula is a unique phrase used when showing a picture to the audience at the beginning of verses. There are two types of verse-introductory formulas in bianwen: ‘~處, 若爲陳說’ and ‘當爾之時, 道何言語?’, and Baxiang bian uses the latter. Keeping the assumption that the form of the performance of bianwen may vary depending on the verse-introductory formula, this paper suggests that the storytelling of Baxiang bian did not use a picture scroll but rather used a mural scene or a large bianxiang containing several scenes Bianwen storytelling was a multimedia performance that included stories, songs, and pictures, and it was very popular at the time. People desire stable possession of popular stories, which leads to the production of works for reading. Since Baxiang bian was also a popular story performance, in this paper, the manuscript of Baxiang bian is considered to be an early form of written work, reflecting its popularity.
Computational Study of Cutting Planes for a Lot-Sizing Problem in Branch-and-Cut Algorithm
Kwanghun Chung(정광헌) 한국경영과학회 2015 한국경영과학회지 Vol.40 No.3
In this paper, we evaluate the strength of three families of cutting planes for a lot-sizing problem. Lot-sizing problem is very basic MIP model for production planning and many strong valid inequalities have been developed for a variety of relaxations in the literature. To use three families of cutting planes in Branch-and-Cut framework, we develop separation algorithms for each cut and implement them in CPLEX. Then, we perform computational study to compare the effectiveness of three cuts for randomly generated instances of the lot-sizing problem.
The effect of 12-hydroxyeicosatetraenoic acid in idiopathic pulmonary fibrosis
( Kwanghun Choi ),( Miae Kim ),( Sujin Moon ),( Hyun Ju Yoo ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Background: Dysregulation of lipid metabolism has been implicated to be important in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the role of 12-hydroxyeicosatetraenoic acid (12S-HETE), a derivative of the arachidonic acid, is not well defined in the pathogenesis of IPF. Methods: The level of 12S-HETE was measured in human plasma (IPF = 76, control = 40) via liquid chromatography-mass spectrometry (LC-MS/MS). Western blot was performed to evaluate the protein expression of collagen type I (collagen I), alpha-smooth muscle actin (α-SMA) and arachidonate 12-lipoxygenase (ALOX12), lipoxygenase- type enzyme that produces 12S-HETE, in human lung tissues and 12S-HETE-treated human lung fibroblast (MRC-5) cells. The function of ALOX12 was confirmed by ALOX12 inhibitor (ML355) and siRNA in MRC-5 cells. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed to evaluate the mRNA expression of epithelial-mesenchymal transition (EMT) markers such as CDH1, E-cadherin coding gene, SNAIL, SLUG and VIM, vimentin coding gene, in 12S-HETE-treated human lung bronchial alveolar epithelial (BEAS-2B) cells. Results: The level of 12S-HETE was increased in plasma of IPF patients compared with controls. The protein levels of collagen I, α-SMA, and ALOX12 were increased in human lung tissues of IPF patients compared with controls. The level of ALOX12 was increased in TGF-β1-treated MRC-5 cells. Moreover, 12S-HETE increased the protein expression of collagen I and α-SMA in MRC- 5 cells, and ML355 and ALOX12 siRNA decreased the protein levels of collagen I, and α-SMA in MRC-5 cells. 12S-HETE increased the mRNA expression levels of SNAIL, SLUG and VIM but, decreased the that of E-cadherin in BEAS-2B cells. Conclusions: Our findings suggest that 12S-HETE may have pro-fibrotic effects by activation of fibroblasts and be implicated as a potential therapeutic target in IPF.
The Effect of Rubicon on autophagy in idiopathic pulmonary fibrosis
( Kwanghun Choi ),( Hak-su Kim ),( Miae Kim ),( Jung Jin Hwang ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Rationale: Autophagy is catabolic process used to degrade and recycle proteins and organelles for cell survival. Dysregulated autophagy impacts the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the mechanism is not well defined. We investigated the effect of RUN domain-containing Beclin1-interacting protein (Rubicon) which is a negative regulator of autophagosome maturation and endocytic pathway in IPF. Methods: Western blot was performed to assess protein expression in human lung tissue (IPF, control), MRC-5 and Beas-2B cells treated with or without TGF-β1 (10 ng/ml). We performed immunoprecipitation with Rubicon antibody to evaluate the interaction of UV radiation resistance-associated gene protein (UVRAG) and RAS-related GTP-binding protein 7 (Rab7). mRNA expression levels was measured via RT-qPCR. Rubicon was down-regulated using siRNA to assess its effect in MRC-5 and Beas-2B cells. Results: The levels of Rubicon was significantly increased in lung tissues of IPF patients compared with those of control lung. Treatment with TGF-β1 increased the level of Rubicon and recruited UVRAG and Rab7 into Rubicon in MRC-5 and Beas-2B cells. TGF-β1-induced mRNA expression level of Rubicon was significantly increased in MRC-5 and Beas-2B cells. The Rubicon siRNA reduced expression levels of collagen I and α-SMA in Beas-2B and MRC-5 cells treated with TGF-β1. Conclusions: We found that Rubicon was increased in human lung tissues and in vitro models of IPF and it suggests that Rubicon may contribute to suppression of autophagy in IPF.
( Kwanghun Choi ),( Miae Kim ),( Sujin Moon ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Lymphangioleiomyomatosis (LAM) is a rare progressive cystic lung disease that mainly affects women of child-bearing age. Vascular endothelial growth factor-D (VEGF-D) was recently considered as a novel diagnostic marker for LAM. We evaluated diagnostic value of serum VEGF-D in Korean patients with LAM. Methods: Serum samples were prospectively obtained from patients with LAM (n = 8) and controls (IPF = 3, NSIP = 3, other cystic lung disease = 4, healthy volunteer = 3). VEGF-D was measured using enzyme-linked immunosorbent assay according to product instruction (R&D SYSTEMS). Results: Of total LAM patients, mean age was 37 years, and all were women. The serum level of VEGF-D was significantly increased in LAM patients compared with control group (mean values: LAM: 3,847.7 pg/mL, IPF: 234.5 pg/mL, NSIP: 227.1 pg/mL, other cystic lung disease: 364.1 pg/mL, healthy controls: 289.4 pg/ mL). In a receiver operating characteristics curve analysis, the optimal cut-off level for LAM diagnosis was 382.3 pg/mL (AUC 0.989, sensitivity 100%, specificity 92.3%, p-value < 0.001). In patients with LAM, 87.5% of patients had serum VEGF-D level over 690 pg/mL. Conclusions: Our findings suggest that serum VEGF-D may be useful in diagnosis of Korean patients with LAM.
박광훈 ( Kwanghun Park ),최정욱 ( Jungug Choi ) 서울대학교 한국정치연구소 2021 韓國 政治 硏究 Vol.30 No.1
이 글은 대한민국의 헌법제정 과정을 다른 동아시아 4개국(일본, 북한, 중화민국, 중화인민공화국)과 비교하여 대한민국 건국의 민주적 정당성을 검토한다. 제헌 과정의 민주적 정당성을 비교하기 위해 헌법제정의 절차의 민주적 정당성을 1) 제헌 기구의 제헌 권한의 민주적 수탁 여부, 2) 외세 개입과 자주성이라는 두 가지 차원으로 나누어 분석한다. 이러한 비교 결과, 대한민국의 헌법제정은 비교 대상인 5개국의 헌법제정 가운데 유일하게 두 차원 모두에서 민주적 정당성을 확보한 사례에 해당한다. 지금까지 대한민국 건국의 정당성에 관한 논의는 주로 역사적 정통성이나 국제적 승인에 초점이 맞추어져 왔는데, 이러한 비교를 통해 민주적 정당성을 중심으로 건국의 의의를 새롭게 조명할 수 있을 것이다. This is a comparative study of the democratic legitimacy of constitution-making process in five post-war East Asian countries: the Republic of Korea(ROK), the Democratic People’s Republic of Korea, Japan, the Republic of China, and the People’s Republic of China. The democratic legitimacy in this study is measured in terms of two separate criteria: the democratic mandate of constitution-making organizations to make a new constitution, and the non-intervention of foreign forces in constitution-making process. Our comparative analysis shows that the constitution-making process of the ROK secured the greatest democratic legitimacy among the five cases by satisfying both criteria. No other countries met both criteria. This finding provides a wholly new approach to the legitimacy issue of the ROK, which is expected to supercede the traditional debates on the issue that have so far focused on the historical and international dimensions of legitimacy.