Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey

Naotaka Ogasawara,Yasushi Funaki,Kunio Kasugai,Masahide Ebi,Yasuhiro Tamura,Shinya Izawa,Makoto Sasaki 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2

Background/AimsDetailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. MethodsThis internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment were also evaluated. ResultsAmong 10 000 survey responses received, functional constipation (Rome IV diagnostic criteria) was reported by 439 participants; chronic constipation (Japanese guidelines) by 3804 participants; and subjective constipation symptoms by 2563 participants. The number of participants with constipation/GERD overlap ranged from 73 to 1533 depending on the criteria used. Regardless of the definition used, all GERD groups had significantly higher odds of being constipated than non-GERD participants: the OR (95% CI) for all 9 combinations of definitions ranged between 1.56 (1.21, 2.01) and 2.67 (2.44, 2.92) (all P ≤ 0.001). Straining, hard stools, and sensations of incomplete evacuation and anorectal obstruction/blockage, according to chronic constipation criteria, were common. Participants with constipation/GERD overlap had poorer quality of life (P < 0.001) and worse GERD symptom scores (P < 0.001). The frequency of abnormal stools was highest (P < 0.001) in the constipation/GERD overlap group. In the overlap group, 52.4% and 26.0% used gastric and constipation medication, respectively. ConclusionIndividuals with constipation/GERD overlap tend to have worsened symptoms and quality of life.

How to Interpret a Functional or Motility Test : How to Interpret a Functional or Motility Test -Slow Nutrient Drinking Test

( Akihito Iida ),( Hiroshi Kaneko ),( Toshihiro Konagaya ),( Kunio Kasugai ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.3

The gastric barostat study is the gold standard method for evaluating gastric perception and accommodation. This technique has serious drawbacks, such as expense and invasiveness. Several drinking tests have been developed as noninvasive methods. Such tests are easily performed without special instruments and are well tolerated. We have reported that (1) a threshold volume inducing mild bloating in the slow nutrient drinking test might be an alternative parameter of gastric accommodation volume as determined by the barostat method and (2) the maximum satiety volume in the drinking test correlated positively with the pressure to induce severe discomfort in healthy volunteers, indicating that the slow nutrient drinking test may be useful for evaluating accommodation volume and the threshold to induce severe discomfort. However, the correlation between the maximum satiety drinking volume and accommodation volume as measured by the barostat study has been controversial. Therefore, validation of a certain nutrient drink test for measuring gastroduodenal function might be recommended in each institution. (J Neurogastroenterol Motil 2012;18:332-335)

Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation

Nakagawa, Takayuki,Kudoh, Keiko,Fukuda, Naoyuki,Kasugai, Shohei,Tachikawa, Noriko,Koyano, Kiyoshi,Matsushita, Yasuyuki,Sasaki, Masanori,Ishikawa, Kunio,Miyamoto, Youji Korean Academy of Periodontology 2019 Journal of Periodontal & Implant Science Vol.49 No.6

Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO₃Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO₃Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO₃Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO₃Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO₃Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO₃Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation

Takayuki Nakagawa,Keiko Kudoh,Naoyuki Fukuda,Shohei Kasugai,Noriko Tachikawa,Kiyoshi Koyano,Yasuyuki Matsushita,Masanori Sasaki,Kunio Ishikawa,Youji Miyamoto 대한치주과학회 2019 Journal of Periodontal & Implant Science Vol.49 No.6

Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO3Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO3Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO3Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO3Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO3Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO3Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

Shape Modification from Endoscope Images by Regression Analysis

Yuji Iwahori,Seiya Tsuda,Aili Wang,Robert J. Woodham,M. K. Bhuyan,Kunio Kasugai 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.9

The VBW (Vogel-Breuß-Weickert) model is proposed as a method to recover 3-D shape under point light source illumination and perspective projection. However, the VBW model recovers relative, not absolute, shape. Here, shape modification is introduced to recover the exact shape. Modification is applied to the output of the VBW model. First, a local brightest point is used to estimate the reflectance parameter from two images obtained with movement of the endoscope camera in depth. A Lambertian sphere image is generated using the estimated reflectance parameter and VBW model is applied for a sphere. Regression analysis is introduced to improve the surface gradients, where linear coefficients can be obtained using true values of gradient parameters with a generated sphere. Depth can then be recovered using the modified gradient parameters. Performance of the proposed approach is confirmed via computer simulation and real experiment.

Predictive Factors for Intractability to Endoscopic Hemostasis in the Treatment of Bleeding Gastroduodenal Peptic Ulcers in Japanese patients

Naotaka Ogasawara,Mari Mizuno,Ryuta Masui,Yoshihiro Kondo,Yoshiharu Yamaguchi,Kenichiro Yanamoto,Hisatsugu Noda,Noriko Okaniwa,Makoto Sasaki,Kunio Kasugai 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.2

Background/Aims: Despite improvements in endoscopic hemostasis and pharmacological therapies, upper gastrointestinal (UGI) ulcersrepeatedly bleed in 10% to 20% of patients, and those without early endoscopic reintervention or definitive surgery might be at ahigh risk for mortality. This study aimed to identify the risk factors for intractability to initial endoscopic hemostasis. Methods: We analyzed intractability among 428 patients who underwent emergency endoscopy for bleeding UGI ulcers within 24hours of arrival at the hospital. Results: Durable hemostasis was achieved in 354 patients by using initial endoscopic procedures. Sixty-nine patients with Forrest typesIa, Ib, IIa, and IIb at the second-look endoscopy were considered intractable to the initial endoscopic hemostasis. Multivariate analysisindicated that age ≥70 years (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.07 to 4.03), shock on admission (OR, 5.26; 95% CI,2.43 to 11.6), hemoglobin <8.0 mg/dL (OR, 2.80; 95% CI, 1.39 to 5.91), serum albumin <3.3 g/dL (OR, 2.23; 95% CI, 1.07 to 4.89), exposedvessels with a diameter of ≥2 mm on the bottom of ulcers (OR, 4.38; 95% CI, 1.25 to 7.01), and Forrest type Ia and Ib (OR, 2.21;95% CI, 1.33 to 3.00) predicted intractable endoscopic hemostasis. Conclusions: Various factors contribute to intractable endoscopic hemostasis. Careful observation after endoscopic hemostasis is importantfor patients at a high risk for incomplete hemostasis.