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      • KCI등재

        Tip Bluntness Transition Measured with Atomic Force Microscopy and the Effect on Hardness Variation with Depth in Silicon Dioxide Nanoindentation

        최주훈,Chad Steven Korach 한국정밀공학회 2011 International Journal of Precision Engineering and Vol. No.

        Depth-sensing indentation measurements of surfaces and structures with indentation depths less than 100 nm necessitate the use of accurate area functions for correct property evaluation. Here, the effect of a blunt nanoindenter tip geometry is characterized using atomic force microscopy to measure the direct tip geometry and modeled by a power law profile shape. Direct measurement of tip geometry is a method to observe changes in the tip curvature and transition from the blunt tip region to an ideal tip geometry. The tip shape, curvature, and transition to ideal geometry is found to correspond with the increase in hardness observed experimentally in SiO2 using a self-similar contact model. For a Berkovich indenter, tip bluntness was found to have a power law degree of 1.5 near the tip apex with a continuously varying degree of bluntness until an ideal pyramidal shape was reached at a depth of 160 nm.

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        Prevalence of Sharing Access Credentials in Electronic Medical Records

        Ayal Hassidim,Tzfania Korach,Rony Shreberk-Hassidim,Elena Thomaidou,Florina Uzefovsky,Shahar Ayal,Dan Ariely 대한의료정보학회 2017 Healthcare Informatics Research Vol.23 No.3

        Objectives: Confidentiality of health information is an important aspect of the physician patient relationship. The use of digital medical records has made data much more accessible. To prevent data leakage, many countries have created regulations regarding medical data accessibility. These regulations require a unique user ID for each medical staff member, and this must be protected by a password, which should be kept undisclosed by all means. Methods: We performed a four-question Google Forms-based survey of medical staff. In the survey, each participant was asked if he/she ever obtained the password of another medical staff member. Then, we asked how many times such an episode occurred and the reason for it. Results: A total of 299 surveys were gathered. The responses showed that 220 (73.6%) participants reported that they had obtained the password of another medical staff member. Only 171 (57.2%) estimated how many time it happened, with an average estimation of 4.75 episodes. All the residents that took part in the study (45, 15%) had obtained the password of another medical staff member, while only 57.5% (38/66) of the nurses reported this. Conclusions: The use of unique user IDs and passwords to defend the privacy of medical data is a common requirement in medical organizations. Unfortunately, the use of passwords is doomed because medical staff members share their passwords with one another. Strict regulations requiring each staff member to have it’s a unique user ID might lead to password sharing and to a decrease in data safety.

      • Risk Factors for Cervical Cancer and CIN3 in Jewish Women in Israel - Two Case Control Studies

        Bassal, Ravit,Schejter, Eduardo,Bachar, Rachel,Perri, Tamar,Korach, Jacob,Jakobson-Setton, Ariella,Ben-David, Liat Hogen,Cohen, Daniel,Keinan-Boker, Lital Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

        Purpose: The aim of the study was to identify risk and protective factors/markers for cervical cancer and cervical intraepithelial neoplasia 3 (CIN3) in Israeli Jewish women in order to settle the discrepancy of low incidence rate of cervical cancer and relatively high incidence rate of CIN3. Materials and Methods: We conducted two case control studies, which examined the association between potential risk and protective factors/markers for cervical cancer or CIN3 using self administered detailed questionnaires. Results: For studying cervical cancer, 40 cases and 40 matched controls were interviewed. In the univariable and multivariable analyses older age, depression or anxiety and ever smoking seemed to act as independent risk factors/markers, while older age at first intercourse was protective. For studying CIN3, 99 cases and 79 controls were interviewed. Multivariable analysis has demonstrated that being born in Israel, depression or anxiety and ever smoking were independent risk factors/markers for CIN3. Conclusions: The risk factors/markers studied, that were associated with cervical cancer or CIN3 among Jewish women in Israel, are similar to those reported in other parts of the world, and do not explain the observed discrepancy of high in-situ cervical cancer rates and low invasive cervical cancer incidence in Israel.

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        Young Israeli women with epithelial ovarian cancer: prevalence of BRCA mutations and clinical correlates

        Limor Helpman,Omri Zidan,Eitan Friedman,Sarit Kalfon,Tamar Perri,Gilad Ben-Baruch,Jacob Korach 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

        Objective: The current study investigates disease patterns and outcomes in young Israeliepithelial ovarian cancer (EOC) patients and their association with BRCA mutation status. Methods: Consecutive EOC patients diagnosed at or below 50 years in a single institutionbetween 1995–2011 were identified. All patients are referred for genetic counseling andtesting for the predominant Jewish BRCA mutations: BRCA1-185delAG, BRCA1-5382insC,and BRCA2-6174delT. A comparison between BRCA mutation carriers and non-carriers wasundertaken across demographic, pathologic, and clinical features; recurrence and survivalwere compared using the Kaplan-Meier method and associations with the variables ofinterest ware analyzed using the Cox proportional hazards method. Results: One hundred eighty-six patients diagnosed with EOC at 50 years or younger wereincluded, with a total follow-up of 1,088 person years. Mean age at diagnosis was 44±5 years. Of 113 patients with documented BRCA testing, 49.6% carried a germline BRCA mutation,compared with 29% in the general Israeli EOC population (p=0.001). BRCA mutationcarriers had a higher rate of serous tumors (75% vs. 64%, p=0.040) and higher CA125 levelsat diagnosis (median, 401 vs. 157, p=0.001) than non-carriers. No significant associationbetween BRCA mutations and recurrence (hazard ratio [HR]=1.03; p=0.940) or survival(HR=1.40; p=0.390) was found. Conclusion: BRCA mutations are encountered in almost 50% of young Israeli ovarian cancerpatients; they are associated with serous tumors and high CA125 levels at diagnosis, but arenot independently associated with recurrence or survival in this patient population.

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