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        Testosterone Deficiency and Nocturia: A Review

        Kazuyoshi Shigehara,Koji Izumi,Atsushi Mizokami,Mikio Namiki 대한남성과학회 2017 The World Journal of Men's Health Vol.35 No.1

        Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels. Therefore, patients with nocturia should receive appropriate treatment in order to improve their quality of life. Nocturia is generally treated by restricting nighttime water intake, as well as by the administration of medications, such as alpha-1 blockers, anticholinergic drugs, and desmopressin. Testosterone replacement therapy (TRT) is used worldwide as a treatment for many hypogonadal conditions. TRT represents an alternative treatment option for nocturia in hypogonadal men. However, limited information is currently available regarding the effects of TRT on nocturia in hypogonadal men, and further studies are required to reach more definitive conclusions.

      • Output Voltage Increase of a Series Resonant DC-DC Converter

        Osamu Matsuo,Hirofumi Matsuo,Yoichi Ishizuka,Koji Kuwahara,Hiroyuki Ota,Katsuhiro Izumi 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

        It has been considered that the series resonant converter takes the maximums of the output voltage in the resonant frequency. However, in practice, the series resonant converter takes the maximums of the output voltage that appears in the lower frequency band compared with the resonant frequency. We analyzed the output voltage characteristics of a series resonant converter circuit when the switching frequency is lower than the resonant frequency including the transformer magnetizing inductance from a transformer. As a result, it was confirmed that for the series resonant converter, the output voltage takes maximum at a lower frequency than the resonant frequency, and the output voltage is larger than the input voltage; that is, the converter has the output boost characteristics, and consequently, this converter can be used when the input voltage is varied widely. In addition, the switching frequency is clarified when the output voltage takes the maximum according to the load resistance and magnetizing inductance.

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        Phosphodiesterase type 5 inhibitor administered immediately after radical prostatectomy temporarily increases the need for incontinence pads, but improves final continence status

        Yasuhiro Kaiho,Shinichi Yamashita,Akihiro Ito,Yoshihide Kawasaki,Hideaki Izumi,Naoki Kawamorita,Hisanobu Adachi,Koji Mitsuzuka,Yoichi Arai 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.5

        Purpose: To evaluate the effects of phosphodiesterase type 5 inhibitor (PDE5i) on urinary continence recovery after bilateral nerve-sparing radical prostatectomy (BNSRP). Materials and Methods: Between 2002 and 2012, 137 of 154 consecutive patients who underwent BNSRP in our institution retrospectively divided into 3 groups that included patients taking PDE5i immediately after surgery (immediate PDE5i group, n=41), patients starting PDE5i at an outpatient clinic after discharge (PDE5i group, n=56), and patients taking no medication (non-PDE5i group, n=40). Using self-administered questionnaires, the proportion of patients who did not require incontinence pads (pad-free patients) was calculated preoperatively and at 1, 3, 6, 12, 18, and 24 months after BNSRP. Severity of incontinence was determined based on the pad numbers and then compared among the 3 groups. Results: Proportions of pad-free patients and severity of incontinence initially deteriorated in all of the groups to the lowest values soon after undergoing BNSRP, with gradual improvement noted thereafter. The deterioration was most prominent in the immediate PDE5i group. As compared to the non-PDE5i group, both the PDE5i and immediate PDE5i groups exhibited a better final continence status. Conclusions: PDE5i improves final continence status. However, administration of PDE5i immediately after surgery causes a distinct temporary deterioration in urinary incontinence.

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