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RISS 인기검색어
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- 저자 : Klingeler, Rü (검색결과 4 건)
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Few-Layer Graphene Shells and Nonmagnetic Encapsulates: A Versatile and Nontoxic Carbon Nanomaterial
Bachmatiuk, Alicja,Mendes, Rafael G.,Hirsch, Cordula,Jä,hne, Carsten,Lohe, Martin R.,Grothe, Julia,Kaskel, Stefan,Fu, Lei,Klingeler, Rü,diger,Eckert, Jü,rgen,Wick, Peter,Rü,mme American Chemical Society 2013 ACS NANO Vol.7 No.12
<P>In this work a simple and scalable approach to coat nonmagnetic nanoparticles with few-layer graphene is presented. In addition, the easy processing of such nanoparticles to remove their core, leaving only the 3D graphene nanoshell, is demonstrated. The samples are comprehensively characterized, as are their versatility in terms of functionalization and as a material for electrochemical storage. Indeed, these 3D graphene nanostructures are easily functionalized much as is found with carbon nanotubes and planar graphene. Electrochemical investigations indicate these nanostructures are promising for stable long-life battery applications. Finally, initial toxicological investigations suggest no acute health risk from these 3D graphene nanostructures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-12/nn4051562/production/images/medium/nn-2013-051562_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn4051562'>ACS Electronic Supporting Info</A></P>
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Hanna Klingel,Maike Lauen,Alexander Krüttgen,Matthias Imöhl,Michael Kleines 대한백신학회 2022 Clinical and Experimental Vaccine Research Vol.11 No.1
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific Tcells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity
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Affaticati, P,Mignen, O,Jambou, F,Potier, M-C,Klingel-Schmitt, I,Degrouard, J,Peineau, S,Gouadon, E,Collingridge, G L,Liblau, R,Capiod, T,Cohen-Kaminsky, S Macmillan Publishers Limited 2011 CELL DEATH AND DIFFERENTIATION Vol.18 No.1
L-glutamate, the major excitatory neurotransmitter, also has a role in non-neuronal tissues and modulates immune responses. Whether NMDA receptor (NMDAR) signalling is involved in T-cell development is unknown. In this study, we show that mouse thymocytes expressed an array of glutamate receptors, including NMDARs subunits. Sustained calcium (Ca<SUP>2+</SUP>) signals and caspase-3 activation in thymocytes were induced by interaction with antigen-pulsed dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine. NMDARs were transiently activated, triggered the sustained Ca<SUP>2+</SUP> signal and were corecruited with the PDZ-domain adaptor postsynaptic density (PSD)-95 to thymocyte-DC contact zones. Although T-cell receptor (TCR) activation was sufficient for relocalization of NMDAR and PSD-95 at the contact zone, NMDAR could be activated only in a synaptic context. In these T-DC contacts, thymocyte activation occurred in the absence of exogenous glutamate, indicating that DCs could be a physiological source of glutamate. DCs expressed glutamate, glutamate-specific vesicular glutamate transporters and were capable of fast glutamate release through a Ca<SUP>2+</SUP>-dependent mechanism. We suggest that glutamate released by DCs could elicit focal responses through NMDAR-signalling in T cells undergoing apoptosis. Thus, synapses between T and DCs could provide a functional platform for coupling TCR activation and NMDAR signalling, which might reflect on T-cell development and modulation of the immune response.
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Brian J. Linder,John B. Gebhart,Amy L. Weaver,Felecia R. Fick,Randina R. Harvey-Springer,Emanuel C. Trabuco,Christopher J. Klingele,John A. Occhino 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.2
Purpose: We compared the degree of pelvic floor symptom improvement between pessary use and prolapse surgery. Materials and Methods: Pessary-naïve women who elected prolapse surgery were enrolled and used a pessary preoperatively (for ≥7 days and ≤30 days). Pelvic floor symptoms were assessed at baseline, after pessary use, and at 3 months postoperatively. The primary outcome was concordance in the degree of symptoms improvement between pessary use and surgery, as assessed by Patient Global Impression of Improvement (PGI-I). Secondary outcomes were related to prolapse specific symptoms on validated questionnaires (POPDI-6, PFIQ-7). The McNemar test was used for comparisons of discordant pairs for comparisons of the PGI-I ratings after pessary use and surgery. Results: Sixty-one participants were enrolled (March 2016 through April 2019) and 58 patients used a pessary. Mean±standard deviation age was 60.7±10.7 years; 24.1% had prior hysterectomy, and 13.8% had prior prolapse surgery. While both treatments demonstrated symptomatic improvement, concordance in the degree of overall improvement on the PGI-I score was poor (n=40); responses significantly favored more improvement postoperatively (p<0.001). Pessary use and surgery were associated with significant improvements in prolapse symptoms from baseline on POPDI-6 (both p<0.001) and POPIQ-7 (pessary, p=0.002; surgery, p<0.001). The degree of improvement was larger postoperatively compared to post-pessary use on POPDI-6 (p<0.001) and PFIQ-7 (p=0.004). Conclusions: Both pessary use and surgery significantly improved pelvic floor symptoms from baseline. However, concordance in degrees of improvement between these treatments was poor, with more favorable outcomes after surgery for prolapse symptoms.
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