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α상분율의 변화가 층상조직 TiAl 합금의 열적안정성에 미치는 영향
金聖雄,이호년,吳明勳,山口正治,韋當文 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.6
The thermal stability of lamellar microstructure in TiAl-Mo PST crystals containing C or Si was investigated. In addition, the variation of α-phase volume fraction in Ti-Al-Mo-(C, Si) systems was also investigated at several temperatures. It was found that Ti-46Al-1.5Mo-O.2C and Ti-46Al-1.5Mo-1.0Si alloys were very stable during heat treatments at various heating rates and temperatures. Moreover, the, α-phase volume fraction of Ti-46A1-1.5Mo-0.2C and Ti-46A1-1.5Mo-1.OSi alloys (stable composition) was less changed than those of Ti-47Al and Ti-46Al-1.5Mo alloys (unstable composition). From these results, the instability of the latter alloys was thought to be resulted from relatively higher variation of α-phase volume fraction during heating. Therefore, it could be suggested that the variation of α-phase volume fraction is an important factor that control the thermal stability of lamellar microstructure.
( Ho Myung Lee ),( Chang Wook Nam ),( Yun Kyeong Cho ),( Hyuck Jun Yoon ),( Hyoung Seob Park ),( Hyung Seop Kim ),( In Sung Chung ),( Yun Seok Heo ),( Seung Ho Hur ),( Yoon Nyun Kim ),( Kwon Bae Kim ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.5
Background/Aims: Although complex bifurcation stenting in patients with nonleftmain (LM) bifurcation lesions has not yielded better clinical outcomes thansimpler procedures, the utility of complex bifurcation stenting to treat LM bifurcationlesions has not yet been adequately explored. Methods: In the present study, patients who underwent LM-to-left anterior descending(LAD) coronary artery simple crossover stenting to treat significantde novo distal LM or ostial LAD disease, in the absence of angiographically significantostial left circumflex (LCX) coronary artery disease, were consecutivelyenrolled. The frequencies of 3-year major adverse cardiovascular events (MACEs;cardiac death, myocardial infarction, and target lesion revascularization), wereanalyzed. Results: Of 105 eligible consecutive patients, only 12 (11.4%) required additionalprocedures to treat ostial LCX disease after main vessel stenting. The mean percentagediameter of ostial LCX stenosis increased from 22.5% ± 15.2% to 32.3% ±16.3% (p < 0.001) after LM-to-LAD simple crossover stenting. The 3-year incidenceof MACEs was 9.7% (cardiac death 2.2%; myocardial infarction 2.2%; target lesionrevascularization 8.6%), and that of stent thrombosis 1.1%. Of seven cases (7.5%)requiring restenosis, pure ostial LCX-related repeat revascularization was requiredby only two. Conclusions: Simple crossover LM-to-LAD stenting without opening of a struton the LCX ostium was associated with acceptable long-term clinical outcomes.
Kim, Johanna Inhyang,Kim, Jae-Won,Lee, Jong-Min,Yun, Hyuk Jin,Sohn, Chul-ho,Shin, Min-Sup,Kim, Bongseog,Chae, Jonghee,Roh, Jaewoo,Kim, Bung-Nyun Elsevier 2018 Progress in neuro-psychopharmacology & biological Vol.82 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The dopamine receptor D2 receptor (<I>DRD2</I>) gene and lead exposure are both thought to contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). ADHD is characterized by delay in brain maturation, most prominent in the prefrontal cortex (PFC). The D2 receptor is also mainly located in the PFC, and animal studies show that lead exposure affects the dopaminergic system of the frontal lobe, indicating an overlap in neural correlates of ADHD, <I>DRD2</I>, and lead exposure. We examined the interaction effects of <I>DRD2</I> rs1800497 and lead exposure on the cortical thickness of the frontal lobe in patients with ADHD.</P> <P><B>Methods</B></P> <P>A 1:1 age- and gender-matched sample of 75 participants with ADHD and 75 healthy participants was included in the analysis. The interaction effects of <I>DRD2</I> and lead exposure on the cortical thickness of 12 regions of interest in the frontal lobe were examined by multivariable linear regression analyses.</P> <P><B>Results</B></P> <P>When we investigated the <I>DRD2</I> ×lead effects in the ADHD and HC groups separately, significant <I>DRD2</I> ×lead effects were found in the ADHD group, but not in the healthy control group in multiple ROIs of the frontal lobe. There was a significant negative correlation between the cortical thickness of the right superior frontal gyrus and inattention scores.</P> <P><B>Conclusions</B></P> <P>The present findings demonstrated significant interaction effects of <I>DRD2</I> and lead exposure on the cortical thickness of the frontal lobe in ADHD. Replication studies with larger sample sizes, using a prospective design, are warranted to confirm these findings.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The dopamine receptor D2 receptor (<I>DRD2</I>) gene and lead exposure contribute to the pathophysiology of ADHD. </LI> <LI> Previous study results indicate an overlap in the neural correlates of ADHD, <I>DRD2</I>, and lead exposure in the prefrontal cortex. </LI> <LI> We found significant interactions between <I>DRD2</I> and lead exposure on the cortical thickness of the frontal lobe in ADHD patients. </LI> <LI> This study highlights the need for consideration of gene-environment interaction when conducting studies regarding dopamine-related genes. </LI> </UL> </P>
Kim, Woosung,Jang, Yoonyoung,Lim, Youn-Hee,Kim, Bung-Nyun,Shin, Choong Ho,Lee, Young Ah,Kim, Johanna Inhyang,Hong, Yun-Chul The Korean Society for Preventive Medicine 2020 예방의학회지 Vol.53 No.1
Objectives: Prenatal cadmium (Cd) exposure may be associated with attention-deficit/hyperactivity disorder (ADHD) in children. Therefore, the objective of this study was to examine the relationship between Cd exposure during gestation and ADHD at 6 years of age. Methods: As part of an ongoing cohort study (the Environment and Development of Children study), 479 mother-child pairs from Seoul, Korea were included for analysis between 2008 and 2011. The whole blood concentration of Cd was analyzed using atomic absorption spectrophotometry. The parents were surveyed about ADHD behaviors in their children at age 6. Multivariable linear regression models were used to investigate the relationship between prenatal exposure to Cd and ADHD at 6 years of age. Results: Increased prenatal Cd concentrations were associated with increased scores for ADHD for girls, but not for boys, at age 6. A 2-fold increase in the prenatal Cd level was significantly associated with a 22.3% (95% confidence interval, 11.6 to 34.1) increase in ADHD in girls at 6 years of age, as indicated by the linear regression model. Conclusions: Our results identified significant associations between prenatal Cd exposure and ADHD scores in 6-year-old girls.
Two Penaeoid Shrimp (Crustacea: Decapoda) New to Korean Waters
Kim, Jung-Nyun,Choi, Jung-Hwa,Choi, Kwang-Ho,Kim, Sung-Tae,Choi, Young-Min The Korean Society of Fisheries and Aquatic Scienc 2007 Fisheries and Aquatic Sciences Vol.10 No.4
We describe two penaeoid shrimp, Hymenopenaeus equalis and Metapenaeus ensis, that were collected from an area northwest of Jeju Island and are new to Korean waters. Hymenopenaeus equalis is the first Korean representative of this genus. A brief distributional and morphological description of the two species is provided.
Two New Records of Crangonid Shrimps (Crustacea: Decapoda: Caridea) in Korean Waters
Kim, Jung-Nyun,Choi, Jung-Hwa,Choi, Kwang-Ho,Kim, Sung-Tae,Chang, Dae-Soo The Korean Society of Systematic Zoology 2008 Animal Systematics, Evolution and Diversity Vol.24 No.3
Two crangonid shrimps, Paracrangon abei Kubo, 1937 and Pontocaris sibogae (De Man, 1918), collected from the northeastern and southeastern waters of Jeju Island, are newly recorded into the Korean fauna. The former is the second species and the latter is the only species of each genus recorded in Korea. Morphological and distributional accounts of these two species are briefly discussed.
New Records of Two Penaeoid Shrimps (Crustacea: Decapoda) from Korean Waters
Kim, Jung-Nyun,Choi, Jung-Hwa,Oh, Taeg-Yun,Hwang, Kang-Seok,Kim, Jong-Bin,Choi, Kwang-Ho,Lee, Dong-Woo The Korean Society of Fisheries and Aquatic Scienc 2010 Fisheries and Aquatic Sciences Vol.13 No.4
Two penaeoid shrimps, Hadropenaeus lucasii (Bate, 1881) and Sicyonia truncata (Kubo, 1949), were collected from the northeastern waters of Jeju Island, Korea. These represent the only Korean reports of a member of the genus Hadropenaeus, family Solenoceridae and of a member of family Sicyonidae, respectively. Morphological descriptions and illustrations with a color photograph of each species are given. Korean Penaeoidea presently includes 27 species in three families.
Remifentanil Protects Human Keratinocyte Through Autophagic Expression
Kim, Eok Nyun,Park, Chang Hoon,Woo, Mi Na,Yoon, Ji Young,Park, Bong Soo,Kim, Yong Ho,Kim, Cheul Hong The Korean Dental Society of Anesthsiology 2014 Journal of Dental Anesthesia and Pain Medicine Vol.14 No.2
Background: Remifentanil, an ultra-short-acting mu-opioid receptor agonist, is unique from other opioids because of its esterase-based metabolism, minimal accumulation, and very rapid onset and offset of clinical action. Remifentanil can prevent the inflammatory response and can suppress inducible nitric oxide synthase expression in a septic mouse model. However, the effects of remifentanil on human keratinocyte and autophagy have yet to be fully elucidated during hypoxia-reoxygenation. Here we investigated whether remifentanil confers protective effect against hypoxia-reoxygenation in human keratinocyte and, if so, whether autophagy mediates this effect. Methods: The human keratinocytes were cultured under 1% oxygen tension. The cells were gassed with 94% $N_2$, and 5% $CO_2$ and incubated for 24 h at $37^{\circ}C$. To determine whether the administration of affects human keratinocytes hypoxia-reoxygenation injury, cells were then exposed to various concentrations of remifentanil (0.01, 0.1, 0.5 and 1 ng/ml) for 2 h. After remifentanil treatment, to simulate reoxygenation and recovery, the cells were reoxygenated for 12 h at $37^{\circ}C$. Control group did not receive remifentanil treatment. Normoxia group did not receive hypoxia and remifentanil treatment for 36 h. 3-MA group was treated 3-methyladenine (3-MA) for 1h before remifentanil treatment. Cell viability was measured using a quantitative colorimetric assay with MTT, showing the mitochondrial activity of living cells. Cells were stained with fluorescence and analyzed with Western blot analysis to find out any relations with activation of autophagy. Results: Prominent accumulation of autophagic specific staining MDC was observed around the nuclei in RPT group HaCaT cells. Similarly, AO staining, red fluorescent spots appeared in RPT group HaCaT cells, while the Normoxia, control and 3-MA groups showed mainly green cytoplasmic fluorescence. We here examined activation of autophagy related protein under H/R-induced cells by Western blotting analysis. Atg5, Beclin-1, LC3-II (microtubule-associated protein 1 light chain 3 form II) and p62 was elevated in RPT group cells. But they were decreased when autophagy was suppressed by 3-MA (Fig. 5). Conclusions: Although the findings of this study are limited to an in vitro interpretation, we suggest that remifentanil may have a beneficial effect in the recovery of wound from hypoxia-reoxygenation injury.
Kim, Taeil,Yoon, Joonsun,Cho, Hwansung,Lee, Wook-bin,Kim, Joon,Song, Young-Hwa,Kim, Se Nyun,Yoon, Jeong Ho,Kim-Ha, Jeongsil,Kim, Young-Joon Nature America Inc 2005 Nature immunology Vol.6 No.2
IκB kinase (IKK) and Jun N-terminal kinase (Jnk) signaling modules are important in the synthesis of immune effector molecules during innate immune responses against lipopolysaccharide and peptidoglycan. However, the regulatory mechanisms required for specificity and termination of these immune responses are unclear. We show here that crosstalk occurred between the drosophila Jnk and IKK pathways, which led to downregulation of each other's activity. The inhibitory action of Jnk was mediated by binding of drosophila activator protein 1 (AP1) to promoters activated by the transcription factor NF-κB. This binding led to recruitment of the histone deacetylase dHDAC1 to the promoter of the gene encoding the antibacterial protein Attacin-A and to local modification of histone acetylation content. Thus, AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-κB target genes.