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Park, Jong Il,Han, sang seop,Jeong, Tae Cheon,Roh, Jung Koo,Kim, Hyoung Chin,Kim, Jeong Hwan,Jeon, Yeong Joong,Kim, Dal Hyun,Kim,Je Hak,Park, Kwan Ha 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1
The antigenic potential of CFA-001, cefazolin, a cephalosporin derivative produced by an enzymatic semisynthesis, was determined in Hartley guinea pigs. A battery of tests employed consisted of active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), and indirect hemagglutination test (IHA). The results were as follows: 1) In ASA, no signs attributable to anaphylaxis was observed in guinea pigs sensitized with CFA-001, whereas OVA-sensitized animals induced severe anaphylactic symptoms; 2) guinea pigs did not produce antibodies against CFA-001 when sensitized with or without Freund's complete adjuvant (FCA) in homologous PCA tests. Meanwhile, antibodies against ovalbumin (OVA) were clearly detected; 3) No CFA-001-specific hemagglutination was observed in the IHA using sera obtained from CFA-001-sensitized guinea pigs. These results suggest that CFA-001 has no antigenicity potential in guinea pigs.
Phase I Dose-Escalation Study of Proton Beam Therapy for Inoperable Hepatocellular Carcinoma
Kim, Tae Hyun,Park, Joong-Won,Kim, Yeon-Joo,Kim, Bo Hyun,Woo, Sang Myung,Moon, Sung Ho,Kim, Sang Soo,Koh, Young-Hwan,Lee, Woo Jin,Park, Sang Jae,Kim, Joo-Young,Kim, Dae Yong,Kim, Chang-Min Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.1
<P><B>Purpose</B></P><P>The purpose of this study is to determine the optimal dose of proton beam therapy (PBT) in hepatocellular carcinoma (HCC) patients.</P><P><B>Materials and Methods</B></P><P>Inoperable HCC patients who had naïve, recurrent, or residual tumor to treatment were considered eligible for PBT. Patients received PBT with 60 GyE in 20 fractions (dose level 1; equivalent dose in 2 Gy fractions [EQD2], 65 GyE<SUB>10</SUB>); 66 GyE in 22 fractions (dose level 2; EQD2, 71.5 GyE<SUB>10</SUB>); or 72 GyE in 24 fractions (dose level 3; EQD2, 78 GyE<SUB>10</SUB>). Dose-limiting toxicity was determined by grade ≥ 3 acute toxicity.</P><P><B>Results</B></P><P>Twenty-seven patients were enrolled; eight, seven, and 12 patients were treated with dose levels 1, 2, and 3, respectively. Overall, treatment was well tolerated, with no dose-limiting toxicities. The complete response (CR) rates of primary tumors after PBT for dose levels 1, 2, and 3 were 62.5% (5/8), 57.1% (4/7), and 100% (12/12), respectively (p=0.039). The 3-and 5-year local progression-free survival (LPFS) rates among 26 patients, excluding one patient who underwent liver transplantation after PBT due to its probable significant effect on disease control, were 79.9% and 63.9%, respectively, and the 3-and 5-year overall survival rates were 56.4% and 42.3%, respectively. The 3-year LPFS rate was significantly higher in patients who achieved CR than in those who did not (90% vs. 40%, p=0.003).</P><P><B>Conclusion</B></P><P>PBT is safe and effective and an EQD2 ≥ 78 GyE<SUB>10</SUB> should be delivered for achievement of local tumor control.</P>
Kim, Yeon-Joo,Lee, Woo Jin,Woo, Sang Myung,Kim, Tae Hyun,Han, Sung-Sik,Kim, Bo Hyun,Moon, Sung Ho,Kim, Sang Soo,Koh, Young Hwan,Park, Sang-Jae,Kim, Joo-Young,Kim, Dae Yong,Park, Joong-Won BioMed Central 2013 Radiation oncology Vol.8 No.-
<P><B>Background</B></P><P>Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes of chemoradiotherapy (CRT) with capecitabine or bolus 5-FU have not been directly compared in patients with locally advanced pancreatic cancer. Therefore, we retrospectively compared the outcomes, including toxicity, tumor response, and overall survival, of oral capecitabine plus radiotherapy (RT) with bolus 5-FU plus RT, in patients with locally advanced pancreatic cancer.</P><P><B>Methods</B></P><P>Between August 2006 and January 2012, 98 patients with locally advanced pancreatic cancer received CRT, with 52 receiving concurrent oral capecitabine and 46 receiving bolus injection of 5-FU. Primary tumor and overall response after CRT were evaluated radiologically, and toxicity, tumor response, and overall survival (OS) were compared in the two groups.</P><P><B>Results</B></P><P>Baseline clinical parameters of the two groups were similar. The rates of ≥ Grade 3 hematologic (0% vs. 8.7%, <I>p</I> = 0.045) and non-hematologic (0% vs. 8.7%, <I>p</I> = 0.045) toxicities were significantly lower in the capecitabine group than in the 5-FU group. Primary tumor (30.7% vs. 28.2%, <I>p</I> = 0.658) and overall (13.7% vs. 15.2%, <I>p</I> = 0.273) response rates and median OS time (12.5 months vs. 11.6 months, <I>p</I> = 0.655) were similar in the two groups.</P><P><B>Conclusions</B></P><P>Capecitabine plus RT may be a safe and feasible regimen for patients with locally advanced pancreatic cancer, with similar efficacy and low rates of toxicities compared with bolus 5-FU plus RT.</P>
Young Dae Yun,Hee Joon Shin,Sung Joong Kim,Sang Wan Lim,Suk Ju Choi,Dong Kyu Seo,Hong Rae Kim,Jung Hee Kim,Joo Sang Lee,Mi Jung Kim,Soon Hee Kim 국제물리치료학회 2010 Journal of International Academy of Physical Ther Vol.1 No.2
The purpose of this study was to analyze and compare the effect of resistance exercise and balance exercise on proprioception and WOMAC index of patients with degenerative knee osteoarthritis. A total of 40 subjects participated in this study. The subjects were diagnosed with degenerative knee osteoarthritis and all were more than 60 years old. They were divided into three groups. Group Ⅰ(n=8) was trained with resistance exercise, Group Ⅱ(n=6) was trained with balance exercise and GroupⅢ(n=6) was trained with range of motion as a control. The results of this study were as follows. It was significantly indicated that the resistance exercise group and balance exercise group elicited error-reduction on proprioception goal-angle (p<.05). There was a statistically significant difference on proprioception between resistance exercise group and control(range of motion) group. There was a statistically significant reduction on WOMAC index between resistance exercise group and balance exercise group (p<.05) and on the WOMAC index between resistance exercise group and range of motion group(p<.05). In conclusion, resistance exercise and balance exercise are effective on degenerative knee osteoarthritis and resistance exercise is the most effective for improving proprioception and WOMAC index. More research on the intervention according to the degree of degenerative knee osteoarthritis is needed.
Sang Jin Jeon,Gi Hun Kim,Hyun Joong Kim,Kwang-Kyu Kim,Sang Kyun Koh,Chi-Young Yun 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Tyrophagus putrescentiae (Tp) as a storage mite inhabitats in stored grains, hay, and straw at agricultural areas. T. putrescentiae stimulates an immune response and triggers inflammatory cytokines release, and thus it is a source of allergen that sensitize and induce allergic reactions. Also, T. putrescentiae has been reported to cause asthma and atopic disease by cross-reactivity with Dermatophagoides pteronyssinus (Dp). The study on T. putrescentiae in human monocytic THP-1 cells is not enough to understand cytokine expression and pathological mechanisms. The aim of this study is to investigate the effect of T. putrescentiae extract (TpE) on production of inflammatory cytokines and expression of mRNA level in THP-1 cells. THP-1 cells are treated with TpE and supernatants were analyzed for the production of cytokines using enzyme-linked immunosorbent assay (ELISA). mRNA level in the culture cells was measured by a reverse transcriptase-polymerase chain reaction (RT-PCR). As a result of this study, TpE significantly induced secretion of interleukin-6, interleukin-8, and monocyte chemotactic protein-1 (MCP-1) in THP-1 cells in time- and dose-dependent manner. These results suggest that TpE may play a role in contributing to inflammatory disease through stimulation of immune cell. Further research of T. putrescentiae is needed to understand the elucidation of the pathogenic mechanism.
Kim, Ki-Joong,Kang, Sang-Jun,Chung, Min-Chul,Jung, Sang-Chul,Jeong, Woon-Jo,Park, Gye-Choon,Kim, Sang-Chai,Boo, Su-Il,Jeong, Seung-Won,Ahn, Ho-Geun American Scientific Publishers 2010 Journal of nanoscience and nanotechnology Vol.10 No.9
<P>Bimetallic Pt-Au catalysts supported on ZnO/Al2O3 were prepared by incipient wetness impregnation (IW-IMP) method with different pretreatment conditions such as flow velocity, calcination temperature, and heating rate under H2 during the calcination procedure, and characterized by X-ray diffraction (XRD), CO chemisorption, and scanning transmission electron microscopy (STEM) equipped energy dispersive spectroscopy (EDS). Furthermore, catalytic activity for complete oxidation of toluene was measured using a flow reactor under atmospheric pressure. Finally, relationship between the particle sizes with pretreatment conditions and catalytic activity for toluene on the bimetallic Pt-Au catalysts was discussed. In these results, nanosized bimetallic Pt-Au particles on ZnO/Al2O3 could be prepared by IW-IMP method. Relationship between the Pt and Au particle size and activity for toluene oxidation was clearly observed.</P>
1H-Benzotriazol-1-y1 Methanesulfonate : A Regioselective N-Mesylating Reagent
Kim, Sun-Young,Sung, Nack-Do,Choi, Joong-Kwon,Kim, Sung-Soo 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
lH-Benzotriazol-l-yl methanesulfonate has been found to be an effective reagent in selective mesylation for differentiating amino groups from one another. In a molecule with both primary and secondary amino groups, mesylation only occurred at the primary amino group. When a compound contains both amino and hydroxy groups, the reagent selectively mesylated at the amino groups.
The Relation of Menarcheal Age to Anthropometric Profiles in Korean Girls
Kim, Ji-Yeong,Oh, In-Hwan,Lee, Eun-Young,Oh, Chang-Mo,Choi, Kyung-Sik,Choe, Bong-Keun,Yoon, Tai-Young,Shin, Sung-Hee,Choi, Joong-Myung The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10
<P>The aim of this study was to represent the trend of early menarche and to assess the association of age at menarche with anthropometric profiles of Korean children and adolescents. A cross sectional survey was conducted with 13,371 girls aged 10 to 18 yr, recruited nationwide from April, 2005 to March, 2006. Height, weight and waist circumference of the subjects were measured; and the subjects self-reported their ages at menarche. We found that the menarcheal girls were taller (<I>P</I><0.05 for the girls between 10 and 14 yr) and heavier (<I>P</I><0.05 for the girls between 10 and 18 yr) than non-menarcheal ones. Menarcheal girls also showed higher body mass index (BMI), and greater waist circumference than non-menarcheal ones. Significant differences were represented according to the age at menarche in terms of BMI, waist circumference, % body fat mass, waist hip ratio and neck circumference as well as height and weight (<I>P</I><0.05). In conclusion, girls who matured early were taller and heavier in early adolescence than those who matured later.</P>
( Sang Il Choi ),( Joong-won Park ),( Bo Hyun Kim ),( Yoosun Choi ),( Byung-ho Nam ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: There has been no prognostic model to evaluate the survival of patients with hepatocellular carcinoma who experience disease recurrence or progression after initial treatment. A model predicting survival of patients with recurrent or progressive hepatocellular carcinoma (MORE score) has recently been developed using clinical parameters, tumor characteristics, initial treatment modality, and response to treatment, and was validated in a single patient cohort. We tried to evaluate the performance of this novel model by applying it to a different prospectively collected patient cohort. Methods: Of 1,010 patients who were newly diagnosed with and who had undergone initial treatment for hepatocellular carcinoma at the National Cancer Center, Korea, between January 2010 and December 2013, 460 had documented disease recurrence or progression. Clinical data at the time of recurrence or progression were collected and reviewed. A newly developed prognostic model, the MORE score, was used to calculate the survival probabilities of these patients at the time of recurrence or disease progression, and its performance was evaluated using C-statistics for discrimination ability and χ2 statistics for fitting ability. Results: The median age was 58.5 years (range, 17-84 years), and the predominant etiology for hepatocellular carcinoma was hepatitis B virus infection (74.3%). The most commonly used initial treatment was chemo-embolization (64.6%), followed by resection (19.6%). The median time to progression after initial treatment was 4.9 months. C-statistics of the MORE score for 1-, 3-, and 5-year survival were 0.892 (95% confidence interval: 0.865-0.919), 0.842 (0.816-0.868) and 0.829 (0.824-0.854) respectively; χ2 statistics showed corresponding values of 9.651, 17.170, and 19.629 for 1-, 3-, and 5-year survival. Conclusions: The MORE score was validated using a different patient cohort that was collected prospectively. The model showed excellent discrimination ability and correctly predicted the survival of the patients, especially at 1 year. This novel model should be useful in real-world clinical practice in communicating with patients and planning subsequent treatment.