http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
보성산 유기농 녹차의 품질에 따른 카테킨 함량과 항산화능 비교 분석
박경련(Kyung Ryun Park),이상길(Sang Gil Lee),남태규(Tae Gyu Nam),김영준(Young Jun Kim),김영록(Young-Rok Kim),김대옥(Dae-Ok Kim) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.1
유기농 녹차의 등급별 총페놀 함량과 항산화능은 각 추출 용매에 따른 수율을 확인하였을 때 물 추출에 비하여 수용성 유기용매의 추출 수율이 유의적으로 높았다. 유기용매를 이용한 추출수율은 물을 이용할 때 보다 총페놀 함량은 1.5에서 3.2배, 항산화능은 1.8에서 3.8배 정도 높게 나타났다. HPLC 분석을 통하여 총페놀 함량과 항산화능의 상관관계를 비교 시 총페놀 함량이 증가함에 따라 항산화능이 1차 선형관계로 증가하는 경향을 보였다. HPLC분석을 통하여 유기농 녹차에 함유되어 있는 다양한 카테킨의 함량이 채엽시기에 따라 변화가 나타났다. 유기농 녹차의 카테킨 성분 중 가장 많이 존재하는 EGCG가 건조중량당 5.8-7.7%의 함량을 보였고, caffeine은 1.7-2.9%의 함량을 보였다. 유기농 녹차의 카테킨 함량은 일반적으로 채엽 시기가 늦어짐에 따라서 점차 감소하였다. 유기농 녹차의 등급에 따른 항산화능은 최상급인 우전에서 가장 높았으며 최하등급인 엽차에서 가장 낮게 나타났다. HPLC 분석에 의한 유기농 녹차의 등급에 따른 총 카테킨 함량(㎎/g)은 우전(155.4), 세작(147.7), 중작(143.2), 엽차(135.1), 대작(130.5)의 순서로 감소하였다. 이를 통해 녹차의 채엽 시기가 유기농 녹차의 카테킨 성분 및 항산화능에도 영향을 미치는 것을 확인하였다. 전반적으로 상급의 유기농 녹차 일수록 총페놀 및 카테킨 함량이 많으며 또한 더 높은 항산화능을 가지는 것으로 나타났다. The objective of this study was to evaluate the effect of various solvents on extraction of bioactive phenolics and to analyze the antioxidant capacity and contents of individual catechins in various grades of green teas organically grown in Boseong, Korea. The organic green teas, based on their harvest seasons, were categorized into five grades such as Woo-Jeon, Se-Jak, Jung-Jak, Dae-Jak, and coarse tea. Solvents used to extract phenolics from these teas included water at 23℃ and 70℃ as well as 80% (v/v) aqueous methanol and ethanol. In general, aqueous organic solvents of methanol and ethanol led to higher extraction yields of phenolics than water at 23℃ and 70℃. Total phenolics and antioxidant capacity of the teas extracted with the aqueous organic solvents were approximately 1.5 to 3.2 and 1.8 to 3.8 times higher than those with water at 23℃ and 70℃, respectively. Coarse tea, the lowest grade of green tea, showed approximately 30-60% lower total phenolics and antioxidant capacity compared with the higher grade ones. Reversed-phase HPLC analysis was performed quantitatively to identify individual catechins, gallic acid, and caffeine in teas extracted with 80% (v/v) aqueous methanol. Based on their dry weights, the organic green teas contained about 1.7 to 2.9% of caffeine. Content (㎎/g dry weight) of tea catechins decreased in the following order: Woo-Jeon (155.4) > Se-Jak (147.7) > Jung-Jak (143.2) > coarse tea (135.1) > Dae-Jak (130.5). (-)-Epigall℃atechin gallate was the most abundant among the catechins analyzed. The highest grade of green tea, Woo-Jeon, had the highest amount of (-)-epigall℃atechin gallate at 77.4 ㎎/g dry weight. Overall, the higher grade of organic green teas tended to have the higher level of antioxidant capacity and catechins.
Comparison of TNF-Mediated Glucose Catabolism between the TNF-Sensitive and -Resistant Cell Lines
Kim, Yeon-Hyang,Park, Bok-Ryun,Cheong, Hee-Sun,Kwon, Oh-Hwan,Kim, Dae-Que,Kim, Soung-Soo Korean Society for Biochemistry and Molecular Biol 1999 Journal of biochemistry and molecular biology Vol.32 No.2
When murine fibrosarcoma L929 cells, a TNF-sensitive cell line, were treated with recombinant human tumor necrosis factor-$\alpha$ (rhTNF-$\alpha$), the activities of glycolytic regulatory enzymes and lactate dehydrogenase increased up to 100-150% compared to the control L929 cells after TNF treatment. By using various metabolic inhibitors and activators, it was found that cAMP-dependent protein kinase is responsible for the increase of activities of the glycolytic enzymes. The activities of glycolytic regulatory enzymes and lactate dehydrogenase of TNF-resistant A549 cells, a human lung carcinoma cell line, did not increase significantly compared to TNF-sensitive L929 cells upon TNF treatment. In contrast, the pyruvate carboxylase activities of A549 cells, but not L929 cells, increased up to 30~40% after TNF treatment. The data suggest that pyruvate carboxylase activity may contribute to the compensation of energy loss mediated by TNF treatment in TNF-resistant A549 cells.
Comparison of TNF-Mediated Glucose Catabolism between the TNF-Sensitive and-Resistant Cell Lines
Kim, Soung Soo,Cheong, Hee Sun,Park, Bok Ryun,Kwon, Hwan Oh,Kim, Yeon Hyang,Kim, Dae Que The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.2
When murine fibrosarcoma L929 cells, a TNF-sensitive cell line, were treated with recombinant human tumor necrosis factor-α(rhTNF-α), the activities of glycolytic regulatory enzymes and lactate dehydrogenase increased up to 100∼150% compared to the control L929 cells after TNF treatment. By using various metabolic inhibitors and activators, it was found that cAMP-dependent protein kinase is responsible for the increase of activities of the glycolytic enzymes. The activities of glycolytic regulatory enzymes and lactate dehydrogenase of TNF-resistant A549 cells, a human lung carcinoma cell line, did not increase significantly compared to TNF-sensitive L929 cells upon TNF treatment. In contrast, the pyruvate carboxylase activities of A549 cells, but not L929 cells, increased up to 30∼40% after TNF treatment. The data suggest that pyruvate carboxylase activity may contribute to the compensation of energy loss mediated by TNF treatment in TNF-resistant A549 cells.
Comparison of TNF-Mediated Glucose Catabolism between the TNF-Sensitive and -Resistant Cell Lines
Kim, Soung Soo,Kim, Yeon Hyang,Cheong, Hee Sun,Kim, Dae Que,Park, Bok Ryun,Kwon, Oh Hwan 생화학분자생물학회 1997 BMB Reports Vol.32 No.2
When murine fibrosarcoma L929 cells, a TNF-sensitive cell line, were treated with recombinant human tumor necrosis factor-a (rhTNF-α), the activities of glycolytic regulatory enzymes and lactate dehydrogenase increased up to 100∼150% compared to the control L929 cells after TNF treatment. By using various metabolic inhibitors and activators, it was found that cAMP-dependent protein kinase is responsible for the increase of activities of the glycolytic enzymes. The activities of glycolytic regulatory enzymes and lactate dehydrogenase of TNF-resistant A549 cells, a human lung carcinoma cell line, did not increase significantly compared to TNF-sensitive L929 cells upon TNF treatment. In contrast, the pyruvate carboxylase activities of A549 cells, but not L929 cells, increased up to 30∼40% after TNF treatment. The data suggest that pyruvate carboxylase activity may contribute to the compensation of energy loss mediated by TNF treatment in TNF-resistant A549 cells.
김대륜(Kim, Dae-ryun) 역사비평사 2014 역사비평 Vol.- No.106
Celebrating fifty years of the publication The Making of the English Working Class written by E. P. Thompson, the author of this paper would like to reconsider its achievements and limitations. First, how much significance did Thompson’s writing have on Korean academics? Why did it contribute to the development of a sustained theoretical and empirical engagement from Korean academic community? Weak points in Thompson’s book and later work on the British Industrial Revolution are examined with respect to two main arguments: (1) Although description of experience of exploitation during the Industrial Revolution occupies a large part of Thompson’s writing, he fails to efficiently present evidence of how the working class experienced such exploitation of their working conditions; (2) Thompson’s arguments do not elucidates sufficiently the various experiences of the working class, how they related with their political involvement and rhetoric. Thompson also fails to recognize the political dynamism of the working class and the relationship between the politics of the middle class and the working class requires further examination and analysis.
( Ki Dae Kim ),( Kang Ryun Moon ),( Ye Jin Kim ),( Sarah Chung ),( Dae Eun Choi ),( Ki Ryang Na ),( Kang Wook Lee ),( Young Tai Shin ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Post-transplant lymphoproliferative disorder (PTLD) in renal transplant recipients has been reported to about 1-3%. PTLDs are classified as polymorphic PTLD, monomorphic PTLD, and other rare types. Although PTLD involves many organs, including the lymph node, lung, gastrointestinal tract, and central nerves system, it is rare that polymorphic PTLD and monomorphic PTLD coexist in renal transplant recipient. We report a rare coexistence of polymorphic PTLD of lung with monomorphic PTLD of small bowel in renal transplant recipient. Case: A 13-years-old girl was admitted to the hospital with the chief complaint of abdominal pain. When she was a newborn, she was diagnosed as Vater syndrome. She started peritoneal dialysis when she was 10 years old, and received a kidney from a deceased donor 8 months ago. She was taking prednisolone 5 mg once, tacrolimus 1.5 mg twice and mycophenolate mofetile 180 mg twice per day. On admission day, there was tenderness and rebound tenderness on whole abdomen. Free air under both diaphragms was found on abdominal radiograph and lung mass was found on chest radiograph. Emergent segmental resection of small intestine and double barrel stomy was done. Histologic diagnosis of small bowel lesion was confirmed as PTLD, monomorphic B-cell type, and EBV in-situ hybridization was positive in most neoplastic cells. Wedge resection of the lung mass was performed. And histologic diagnosis of lung mass was polymorphic PTLD. We started weekly administration of rituximab (325 mg/m2/week). Lung nodules were significantly decreased in size on last follow up CT scan without significant complication after 4th dose of rituximab.
구제요법으로 시행한 소라페닙 치료에 극적인 반응을 보인 폐전이를 동반한 진행성 간세포암종 1예
김대하 ( Dae-ha Kim ),민지호 ( Gee Ho Min ),이동원 ( Dong-won Lee ),안계련 ( Ke Ryun Ahn ),김지혜 ( Ji Hye Kim ),서상준 ( Sang-jun Suh ),정영걸 ( Young Kul Jung ),임형준 ( Hyung Joon Yim ) 대한간암학회 2016 대한간암학회지 Vol.16 No.1
Sorafenib is a multi-targeted tyrosine kinase inhibitor that inhibits Raf kinase and the vascular endothelial growth factor receptor intracellular kinase pathway and is the first agent to demonstrate a statistically significant improvement in overall survival for patients with advanced hepatocellular carcinoma (HCC). However, there were few cases of partial or complete response reported in the previous studies. We herein report a case of dramatic partial response in a patient who had advanced HCC with multiple lung metastasis and portal vein thrombosis treated with sorafenib. (J Liver Cancer 2016;16:57-62)