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鄭慶逸,李輔鎬 大田工業高等專門學校 1968 論文集 Vol.3 No.-
The Torque Charaeteristics of motors are generally obtained by calculation or circle diagram this device can measure very speed, the torque characteristics of motors by oscilloscope. It's error is small 5%.
Keyong Ho Lee,이기형 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
The purpose of this investigation was to extract the bioactive agents from Alpinia officinarum Hance. The methanol with ethylacetate extracts alone and combined were examined for their activities against VRE (vancomycin-resistant enterococci) and pathogenic yeast in vitro. The incidence of infections caused by VRE and other pathogenic microorganisms and the importance of using novel synergistic drug combinations has become important. Previously, we reported the antimicrobial effects of the butanol extract from Lonicera japonica and have evaluated combinations of solvent extracts, with a focus on the MeOH and EtOAc extracts from A. officinarum. In the present study, enhanced inhibitory effects were achieved by employing a combination of the two solvent extracts. The MeOH and EtOAc combination was especially effective against four VRE strains: E. faecalis (K-10-22), E. faecaium (K-11-212), E. faecalis (K-10-57) and E. faecalis (K-10-361) with MIC values of 12.5, 12.5, 6.25 and 25 mg/mL, respectively. Thus, the combination was more effective than other antibiotics such as kanamycin, gentamicin or tetracycline against bacteria including E. coli, Staphylococcus aureus, and Micrococcus luteus. In addition, the combination was effective against yeasts such as Candida albicans, Candida tropicalis and Cryptococcus neoformans.
Anti-tumor Activity of Paclitaxel Prodrug Conjugated with Polyethylene Glycol
Lee, Keyong-Ho,Chung, Yong-Jun,Kim, Youn-Chul,Song, Seog-Jeong Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.7
The purpose of this study was to develop a method for increasing the solubility of paclitaxel in water to reduce its toxicity and make the drug more feasible for chemotherapy. A series of highly water soluble paclitaxel polyethylene glycol (PEG) esters were synthesized and evaluated for their anti-tumor activity and toxicity. The solubility of 7-polyethylene glycol paclitaxel carbonate 5 was 840 mg/mL and the acute toxicity ($LD_{50}$) was 286 mg/kg. Because of its reduced toxicity, compound 5 showed a dramatic reduction of tumor volume without any loss of animals in long-term treatment (daily consecutive injections for 15 days).
Correlative effect between in vivo hollow fiber assay and xenografts assay in drug screening.
Lee, Keyong Ho,Rhee, Ki Hyeong The Korean Cancer Association 2005 Cancer Research and Treatment Vol.37 No.3
<P>This study was carried out to assess the usage of an in vivo hollow fiber assay to screen drugs with highly predictive accuracy.</P>
Antimalarial activity of nepodin isolated from Rumex crispus
Keyong Ho Lee,Ki Hyeong Rhee 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.4
The purpose of this study is to define the antimalarialactivity of Rumex crispus. To identify an activecompound that is isolated from R. crispus, bioassay-basedchromatographic fractionation and purification is carried outfrom 70 % ethanol extract of R. crispus; then, an activecompound, nepodin, is identified by spectroscopic analysis. Anitmalarial activity is measured by PfNDH2 assay, cytotoxicity,and animal test. From NADH:quinone oxidoreductaseenzyme (PfNDAH2) assay, nepodin exhibitedsignificant IC50 values that were 0.74 ± 0.07 and0.79 ± 0.06 lg/ml against P. falciparum chloroquine-sensitive(3D7) and P. falciparum chloroquine-resistant (S20),respectively. Nepodin showed a potential selective inhibition(SI index: ratio of 50 %cytotoxic concentration to 50 %effective anti-plasmodial concentration) of 161.6 and 151.4against P. falciparum 3D7 and P. falciparum S20. In theanimal test, all groups of nepodin treatment of 10, 50, and250 mg/kg were active with a parasitemia suppression of97.1 ± 3.3, 99.1 ± 3.7, and 99.1 ± 2.6 %, respectively. The survival time with nepodin treatment was increased by14.6 ± 2.5, 16.2 ± 1.5, and 19.8 ± 1.7 days at each dose,respectively. This study newly identified the plant R. crispuscontaining nepodin, which is a potential antimalarial compound. It exhibited the inhibitory activity of PfNDH2 andprolonged the survival time on the group of nepodin treatment;moreover, it inhibited the parasitemia in the animaltest.
Anti-tumor Activity of Paclitaxel Prodrug Conjugated with Polyethylene Glycol
Keyong Ho Lee*,Yong Jun Chung,Youn-Chul Kim,Seog Jeong Song 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.7
The purpose of this study was to develop a method for increasing the solubility of paclitaxel in water to reduce its toxicity and make the drug more feasible for chemotherapy. A series of highly water soluble paclitaxel polyethylene glycol (PEG) esters were synthesized and evaluated for their anti-tumor activity and toxicity. The solubility of 7-polyethylene glycol paclitaxel carbonate 5 was 840 mg/mL and the acute toxicity (LD50) was 286 mg/kg. Because of its reduced toxicity, compound 5 showed a dramatic reduction of tumor volume without any loss of animals in long-term treatment (daily consecutive injections for 15 days).
Antimutagenic and AntileukemicActivities of Aloes vera L.
Keyong Ho Lee,Hee Gon Kang,Choa Hyoung Cho,Moon Joon Lee,Jae Hyun Lee,Chang Han Kim 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
We investigated that the extract of Aloe vera L. and its fractions exert antimutagenic activity against Salmonella typhimurium TA98 and TA100, and antileukemic effect against K562 human leukemia cell line. The aqueous ethanolic extract of A. vera L. was revealed to have antimutagenic effect on the AF-2 (2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide) in Salmonella mutation assay. Among the three fractions (fractions A, B and C) separated by silica gel chromatography, fraction C (50 ㎍/plate) exhibited the greatest antimutagenic effect on the AF-2 with inhibition rate of 84 and 90% in Salmonella typhimurium TA98 and TA100, respectively. The fraction C (500 ㎍/㎖) inhibited the growth of K562 human leukemia cell line by 93% in MTT assay. However, the components of A. vera L. did not exhibit cytotoxic effect against MDBK bovine normal kidney in MTT assay.
Keyong Ho Lee,Jae Hyun Lee,Choa Hyoung Cho,Moon Jong Noh,Young Bum Kim 한국생약학회 2001 Natural Product Sciences Vol.7 No.2
Ulmus davidiana, Formitella fraxinea, and Aloe vera extracts were detected to have inhibitory effects against topoisomerase I at treatment of Spg. Ulmus davidiana and Aloe vera extracts were found to show inhibitory effect similar to camptothecin, Formitella fraxinea extract was found to have weak activity. We also found the potential use of those extracts as a radiation sensitizer. Radiosensitizing effect at combination treatment was increased more than 2 times at single treatment of radiation, Ulmus davidiana or Formitella fraxinea extracts. Ulmus davidiana and Formitella fraxinea extracts were found to have significant radiosensitizing effect on test tumor cell line. But, Aloe vera extract was not detected to have activity as a radiosensitizer. Ulmus davidiana and Formitella fraxinea extracts are potent radiosensitizers on tumor cell lines and should be considered for further study of active compounds.
Keyong Ho Lee,윤원호 한국생약학회 2011 Natural Product Sciences Vol.17 No.3
We investigated the effects of fucoidan and lutein against dextran sulfate sodium (DSS)-induced mice colitis. Evaluations were made of the body weight, histological index such as crypt injury and inflammation score, biochemical factor such as serum amyloid (SAA) and MPO level data. The combination of fucoidan and lutein reduced the score of crypt injury and inflammation and markedly showed more decrease of the SAA and MPO levels than 5-ASA group. In addition, each sample of fucoidan and lutein was reduced the level of IL-6 which is stimulated by a lipopolysaccharide (LPS) in HT-29 cell line in vitro. Therefore, fucoidan and lutein may be useful as a dietary substance for preventing inflammatory bowel disease in humans.