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- 저자 : Kesevan Rajah Kumaran (검색결과 1 건)
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Kesevan Rajah Kumaran,Habibah A. Wahab,Zurina Hassan 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3
Vascular dementia (VaD) is associated with the loss of cognitive function. The pharmacotherapy for dementia is cholinesterase inhibitor (ChEI). However, currently available ChEIs produce side efects. Therefore, new anticholinesterase agents are required for treating dementia. In vitro assays showed that Syzygium polyanthum leaf extract (SPLE) inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. Here, we evaluated the nootropic efect of SPLE, mediated via a cholinergic system with long-term hippocampal plasticity (LTP) in chronic cerebral hypoperfusion (CCH) rats. Male Sprague Dawley (SD) rats were subjected to permanent bilateral occlusion of common carotid arteries (POBCCA) or sham groups. An automated open feld test (AOFT) was conducted to examine motor and exploratory functions. Cognitive functions were evaluated using Novel object recognition (NOR) and Morris water maze (MWM) tests. At the end of the behavioral task, the brain was harvested to determine cholinesterase, choline acetyltransferase (ChAT), acetylcholine (ACh), and brainderived neurotrophic factor (BDNF) activities. Hippocampal synaptic plasticity was measured under urethane anesthetized rats. The study revealed SPLE (100, 200, and 300 mg/kg) (i) improved both non-spatial and spatial memories in NOR and MWM tests, respectively; (ii) promoted long-lasting LTP enhancement in CA3-CA1 synapses; (iii) increased the ACh, ChAT and BDNF activities in the frontal cortex, hippocampus and cerebral cortex. Interestingly, the elevated AChE activity in the hippocampus was signifcantly inhibited by SPLE extract. SPLE executes its cognitive functions by restoration of the cholinergic system. The fndings support the therapeutic potential of SPLE in the treatment of VaD.
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