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Brian Kenneth E. Eduarte,Nicole Andrey Acosta,Jenela Pauline Lumanlan,Jhevia E. agnampo,Diana Rose Medrano,Kaori Ann B. Vicente,James Patrick C. Picar ASCONS 2019 IJBSA Vol.1 No.1
Background/Objectives: The fire related injuries such as burns are one of the main problems of the community. It is because of the insufficient ideas in wound healing and lack of financial capabilities resulting into self-medication. Methods/Statistical analysis: In this study, the researchers will prepare an ointment from milkfish skin and scale added to soft paraffin in 70 C until it congeals. The milkfish is known having high content of riboflavin and vitamin B complex that is a big impact to fasten the first-degree burn healing process. The milkfish skin and scales are also to be extracted using Gamma Irradiation as a manner of sterilization and for preservation of collagen and vitamin B content. The experimental rats will be induced of burn wounds by 5 seconds in the back part using cylindrical heat steel to be associated in 100C boiling water which will be treated with the prepared ointment. The epithelialization times, wound contraction and histological examination will be observed and the data recorded is to be analyzed using one-way ANOVA and repeated measures. Findings: This study deals with scientific experimentation to identify the potential of Milkfish skin and scale in wound healing. Improvements/Applications: If proven effective, it may be utilized as an alternative wound healing agent.
Zhu, Ping,Baek, Sung Hee,Bourk, Eliot M.,Ohgi, Kenneth A.,Garcia-Bassets, Ivan,Sanjo, Hideki,Akira, Shizuo,Kotol, Paul F.,Glass, Christopher K.,Rosenfeld, Michael G.,Rose, David W. Elsevier 2006 Cell Vol.124 No.3
<P><B>Summary</B></P><P>Defining the precise molecular strategies that coordinate patterns of transcriptional responses to specific signals is central for understanding normal development and homeostasis as well as the pathogenesis of hormone-dependent cancers. Here we report specific prostate cancer cell/macrophage interactions that mediate a switch in function of selective androgen receptor antagonists/modulators (SARMs) from repression to activation in vivo. This is based on an evolutionarily conserved receptor N-terminal L/HX<SUB>7</SUB>LL motif, selectively present in sex steroid receptors, that causes recruitment of TAB2 as a component of an N-CoR corepressor complex. TAB2 acts as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1, which in turn mediates dismissal of the N-CoR/HDAC complex and permits derepression of androgen and estrogen receptor target genes. Surprisingly, this conserved sensor strategy may have arisen to mediate reversal of sex steroid-dependent repression of a limited cohort of target genes in response to inflammatory signals, linking inflammatory and nuclear receptor ligand responses to essential reproductive functions.</P>