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Predictors and outcomes of laparoscopic nephrectomy in autosomal dominant polycystic kidney disease
Kenneth Chen,Yu Guang Tan,Darren Tan,Gregory Pek,Hong Hong Huang,Soon Phang Allen Sim 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.4
Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications. Traditionally, nephrectomies were performed via the open approach in view of space constraints. We evaluate our institution's outcomes for laparoscopic nephrectomy (LN) for ADPKD. Materials and Methods: We retrospectively reviewed 33 patients with ADPKD who underwent nephrectomies from November 2005 to December 2016 at a tertiary institution. Preoperative kidney volume was calculated via the ellipsoid method by using computed tomography scan. Results: The median age was 51.0 years (interquartile range [IQR], 44.5–56.0 years). Sixteen patients (48.5%) underwent open nephrectomy (ON), 15 patients (45.5%) had LNs, and 2 patients (6.1%) had laparoscopic converted to ON due to dense adhesions. Thirteen patients had bilateral while 18 patients had unilateral nephrectomies. Median kidney volume in the open group was 1,042 cm3 (IQR, 753–2,365 cm3) versus 899 cm3 (IQR, 482–1,914 cm3) in the laparoscopy group and did not differ significantly. The operative time was comparable between both groups. Patients who underwent LN had lesser blood loss (350 mL vs. 650 mL; 95% confidence interval [CI], 1.822–3.533; p=0.016) and shorter length of hospital stay (4.0 days vs. 6.5 days; 95% CI, 1.445–5.755; p=0.001) compared to patients who underwent ON. Both groups had similar low morbidity rate and no mortality.
Hong Yi Kenneth Tan,Jong Dae Baek,Chen-Nan Sun,JUN WEI,이성혁,Pei-Chen Su 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.2
A simple and effective technique to reduce the overall fuel cell polarization resistance was introduced on a conventionally sintered YSZ electrolyte by creating a hybrid microstructure using low-intensity CO2 laser scanning methods. After laser modification of the YSZ electrolyte surface on the cathode side, the overall polarization resistance was reduced from 513 to 124 Ω cm2, and the maximum power density was increased by 28% from 1.86 to 2.38 mW/cm2 at 450 °C. This improvement was due to the enhanced surface kinetics by higher grain boundary density on the YSZ surface from recrystallization after laser scanning.
Damage evaluation of seismic response of structure through time-frequency analysis technique
Chen, Wen-Hui,Hseuh, Wen,Loh, Kenneth J.,Loh, Chin-Hsiung Techno-Press 2022 Structural monitoring and maintenance Vol.9 No.2
Structural health monitoring (SHM) has been related to damage identification with either operational loads or other environmental loading playing a significant complimentary role in terms of structural safety. In this study, a non-parametric method of time frequency analysis on the measurement is used to address the time-frequency representation for modal parameter estimation and system damage identification of structure. The method employs the wavelet decomposition of dynamic data by using the modified complex Morlet wavelet with variable central frequency (MCMW+VCF). Through detail discussion on the selection of model parameter in wavelet analysis, the method is applied to study the dynamic response of both steel structure and reinforced concrete frame under white noise excitation as well as earthquake excitation from shaking table test. Application of the method to building earthquake response measurement is also examined. It is shown that by using the spectrogram generated from MCMW+VCF method, with suitable selected model parameter, one can clearly identify the time-varying modal frequency of the reinforced concrete structure under earthquake excitation. Discussions on the advantages and disadvantages of the method through field experiments are also presented.
Chen, Peng,Holinsworth, Brian S.,O’Neal, Kenneth R.,Luo, Xuan,Topping, Craig V.,Cheong, Sang W.,Singleton, John,Choi, Eun S.,Musfeldt, Janice L. American Chemical Society 2018 Inorganic Chemistry Vol.57 No.20
<P>We bring together <I>ac</I> susceptibility and <I>dc</I> magnetization to uncover the rich magnetic field-temperature behavior of a series of rare earth indium oxides, RInO<SUB>3</SUB> (R = Tb, Dy, and Gd). The degree of frustration is much larger than expected, particularly in TbInO<SUB>3</SUB>, and the ground states are glasslike with antiferromagnetic tendencies. The activation energy for spin reorientation is low. Chemical substitution with Mn<SUP>3+</SUP> ions to form TbIn<SUB>1-<I>x</I></SUB>Mn<SUB><I>x</I></SUB>O<SUB>3</SUB> (<I>x</I> ≤ 0.01) relieves much of the frustration that characterizes the parent compound and slightly enhances the short-range antiferromagnetic order. The phase diagrams developed from this work reveal the rich competition between spin orders and provide an opportunity to compare the dynamics in the RInO<SUB>3</SUB> and Mn-substituted systems. These structure-property relations may be useful for understanding magnetism in other geometrically frustrated multiferroics.</P><P>We combined <I>dc</I> magnetization and <I>ac</I> susceptibility to reveal the rich magnetic field-temperature phase diagrams of a series of rare earth indium oxides. These systems sport high degrees of frustration as described by the frustration index, <I>F</I>, as well as glasslike slow magnetic relaxation in combination with antiferromagnetic tendencies. Structure−composition−property investigations reveal that both the choice of rare earth center as well as introduction of a paramagnetic impurity like Mn<SUP>3+</SUP> can control frustration in this new class of geometrically frustrated multiferroics.</P> [FIG OMISSION]</BR>
Enhanced Cold Wall CVD Reactor Growth of Horizontally Aligned Single-Walled Carbon Nanotubes
Wei Mu,곽은혜,Bingan Chen,Shirong Huang,Michael Edwards,Yifeng Fu,Kjell Jeppson,Kenneth Teo,정구환,Johan Liu 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.3
Synthesisof horizontally-aligned single-walled carbon nanotubes (HA-SWCNTs) bychemical vapor deposition (CVD) directly on quartz seems very promising for thefabrication of future nanoelectronic devices. In comparison to hot-wall CVD, synthesisof HA-SWCNTs in a cold-wall CVD chamber not only means shorter heating, coolingand growth periods, but also prevents contamination of the chamber. However, sincemost synthesis of HA-SWCNTs is performed in hot-wall reactors, adapting this wellestablishedprocess to a cold-wall chamber becomes extremely crucial. Here, in orderto transfer the CVD growth technology from a hot-wall to a cold-wall chamber, asystematic investigation has been conducted to determine the influence of processparameters on the HA-SWCNT’s growth. For two reasons, the cold-wall CVDchamber was upgraded with a top heater to complement the bottom substrate heater;the first reason to maintain a more uniform temperature profile during HA-SWCNTsgrowth, and the second reason to preheat the precursor gas flow before projecting itonto the catalyst. Our results show that the addition of a top heater had a significanteffect on the synthesis. Characterization of the CNTs shows that the average density ofHA-SWCNTs is around 1 - 2 tubes/μm with high growth quality as shown by Ramananalysis.
Sano, Tetsuro,Lin, Huai,Chen, Xiashan,Langford, Lauren A.,Bondy, Dimpy Koul Melissa L.,Hess, Kenneth R.,Myers, Jeffery N.,Hong, Yong-Kil,Yung, W.K. Alfred,Steck, Peter A. 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
MMAC/PTEN, a tumor suppressor gene located on chromosome 10q, has recently been shown to act as a phosphatidylinositol 3,4,5-triphosphate phosphatase and to modulate cell growth and apoptosis. Somatic mutations of MMAC/PTEN have been reported in a number of human cancers, especially in glioblastoma multiforme (GBM), although the number of identified mutations (10-35%) is significantly lower than the frequency of LOH affecting the MMAC/PTEN locus in the specimens (75-95%). To further investigate the possible alterations that may affect MMAC/PTEN, we examined the expression of the gene by reverse transcription-PCR in a series of gliomas. A significant difference (P<0.001) was observed between the expression of MMAC/PTEN in GBMs versus lower grades of gliomas, thus mimicking the difference in allelic deletion associated with the locus in these tumors. Furthermore, Kaplan-Meier survival plots, adjusted for age and tumor grade, showed a significantly better prognosis for patients whose tumors expressed high level of MMAC/PTEN. Additionally, immunostaining of GBMs revealed little or no MMAC/PTEN expression in about two-thirds of the tumors, whereas the other approximately one-third of tumors had significantly higher levels of expression. However, in about two-thirds of the gigh-expressing specimens, a heterogeneous pattern of expression was observed, indicating that certain cells within the tumor failed to express MMAC/PTEN. The combination of these results suggest that, in addition to molecular alterations affecting the gene, altered expression of MMAC/PTEN may play a significant role in the progression of GBM and patient outcome. (Cancer Research 59:1820-1824, 1999)
Ke Yang,Yifan Chen,Kenneth Kin Wah To,Fang Wang,Delan Li,Likun Chen,Liwu Fu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Alectinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by the Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC). Here we investigated the reversal effect of alectinib on multidrug resistance (MDR) induced by ATP-binding cassette (ABC) transporters, which is the primary cause of chemotherapy failure. We provide the first evidence that alectinib increases the sensitivity of ABCB1- and ABCG2-overexpressing cells to chemotherapeutic agents in vitro and in vivo. Mechanistically, alectinib increased the intracellular accumulation of ABCB1/ABCG2 substrates such as doxorubicin (DOX) and Rhodamine 123 (Rho 123) by inhibiting the efflux function of the transporters in ABCB1- or ABCG2-overexpressing cells but not in their parental sensitive cells. Furthermore, alectinib stimulated ATPase activity and competed with substrates of ABCB1 or ABCG2 and competed with [125I] iodoarylazidoprazosin (IAAP) photolabeling bound to ABCB1 or ABCG2 but neither altered the expression and localization of ABCB1 or ABCG2 nor the phosphorylation levels of AKT and ERK. Alectinib also enhanced the cytotoxicity of DOX and the intracellular accumulation of Rho 123 in ABCB1-overexpressing primary leukemia cells. These findings suggest that alectinib combined with traditional chemotherapy may be beneficial to patients with ABCB1- or ABCG2-mediated MDR.