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Kenichiro Eshima,Hiroki Ohzono,Masafumi Gotoh,Hisao Shimokobe,Koji Tanaka,Hidehiro Nakamura,Tomonoshin Kanazawa,Takahiro Okawa,Naoto Shiba 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.2
Background: Massive rotator cuff tears (RCTs) are complicated by muscle atrophy, fibrosis, and intramuscular fatty degeneration, which are associated with postoperative tendon-to-bone healing failure and poor clinical outcomes. We evaluated muscle and enthesis changes in large tears with or without suprascapular nerve (SN) injury in a rat model. Methods: Sixty-two adult Sprague-Dawley rats were divided into SN injury (+) and SN injury (–) groups (n=31 each), comprising tendon (supraspinatus [SSP]/infraspinatus [ISP]) and nerve resection and tendon resection only cases, respectively. Muscle weight measurement, histological evaluation, and biomechanical testing were performed 4, 8, and 12 weeks postoperatively. Ultrastructural analysis with block face imaging was performed 8 weeks postoperatively. Results: SSP/ISP muscles in the SN injury (+) group appeared atrophic, with increased fatty tissue and decreased muscle weight, compared to those in the control and SN injury (–) groups. Immunoreactivity was only positive in the SN injury (+) group. Myofibril arrangement irregularity and mitochondrial swelling severity, along with number of fatty cells, were higher in the SN injury (+) group than in the SN injury (–) group. The bone-tendon junction enthesis was firm in the SN injury (–) group; this was atrophic and thinner in the SN injury (+) group, with decreased cell density and immature fibrocartilage. Mechanically, the tendon–bone insertion was significantly weaker in the SN injury (+) group than in the control and SN injury (+) groups. Conclusions: In clinical settings, SN injury may cause severe fatty changes and inhibition of postoperative tendon healing in large RCTs.
Anti-Tumor effect and Immunological Enhancement in Fuscoporia obliqua
Yeunhwa Gu,Kenichiro Tanaka,Takashi Nakamura,Masayuki Tajima,Takenori Yamashita,Takeo Hasegawa,Kaoru Terai,Hiroyuki Iwasa,Hajime Monzen,Masami Oshima,Eunsuk Choi,Kyoo Seok Ahn,Tetsuo Takeuchi,Mituhana 한의병리학회 2004 대한동의병리학회 학술대회논문집 Vol.2004 No.8
Anti-Tumor effect and Immunological Enhancement in Fuscoporia obliqua
Yeunhwa Gu,Kenichiro Tanaka,Tankashi Nakamura,Masayuki Tajima,Takenori Yamashita,Takeo Hasegawa,Kaoru Terai,Hiroyuki Iwasa,Hajime Monzen,Masami Oshima,Eunsuk Choi,Kyoo Seok Ahn,Tetsuo Takeuchi,Mituhan 한의병리학회 2004 대한동의병리학회 학술대회논문집 Vol.2004 No.8
Anti-Cancer and Radiation Protection Effects by Ganoderma Lucidum
Yeunhwa Gu,Kouri Ryutarou,Takashi Nakamura,Kenichiro Tanaka,Masayuki Tajima,Takenori Yamashita,Hiroaki Tanabe,Daigo Matsumoto,Hajime Monzen,Masami Oshima,Eunsuk Choi,Ikukatsu Suzuki,Kyoo Seok Ahn,Tets 한의병리학회 2004 대한동의병리학회 학술대회논문집 Vol.2004 No.8
Anti-Cancer and Radiation Protection Effects by Ganoderma Lucidum
Yeunhwa Gu,Kouri Ryutarou,Takashi Nakamura,Kenichiro Tanaka,Masayuki Tajima,Takenori Yamashita,Hiroaki Tanabe,Daigo Matsumoto,Hajime Monzen,Masami Oshima,Eunsuk Choi,Ikukatsu Suzuki,Kyoo Seok Ahn,Tets 한의병리학회 2004 대한동의병리학회 학술대회논문집 Vol.2004 No.8
Natural History of Early Gastric Cancer: a Case Report and Literature Review
Tomohiro Iwai,Masao Yoshida,Hiroyuki Ono,Naomi Kakushima,Kohei Takizawa,Masaki Tanaka,Noboru Kawata,Sayo Ito,Kenichiro Imai,Kinichi Hotta,Hirotoshi Ishiwatari,Hiroyuki Matsubayashi 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1
Early detection and treatment decrease the mortality rate associated with gastric cancer (GC). However, the natural history of GC remains unclear. An 85-year-old woman was referred to our hospital for evaluation of a gastric tumor. Esophagogastroduodenoscopy identified a 6 mm, flat-elevated lesion at the lesser curvature of the antrum. A biopsy specimen showed a well-differentiated tubular adenocarcinoma.
Anti-tumor Immunity and Radioprotection Effect by Fuscoporia oblique
Yeunhwa Gu,Yuka Itokawa,Toshihiro Maenaka,Takenori Yamashita,Kenichiro Tanaka,Koru Tano,Hiroyo Kondo,Insuk Choi,Torao Ishida,Takashi Nakamura,Kiyoto Saito,Kaoru Terai,Hajime Monzen,Masami Oshima,Tetsu 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8
Natural History of Early Gastric Cancer: a Case Report and Literature Review
Iwai, Tomohiro,Yoshida, Masao,Ono, Hiroyuki,Kakushima, Naomi,Takizawa, Kohei,Tanaka, Masaki,Kawata, Noboru,Ito, Sayo,Imai, Kenichiro,Hotta, Kinichi,Ishiwatari, Hirotoshi,Matsubayashi, Hiroyuki The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1
Early detection and treatment decrease the mortality rate associated with gastric cancer (GC). However, the natural history of GC remains unclear. An 85-year-old woman was referred to our hospital for evaluation of a gastric tumor. Esophagogastroduodenoscopy identified a 6 mm, flat-elevated lesion at the lesser curvature of the antrum. A biopsy specimen showed a well-differentiated tubular adenocarcinoma. The depth of the lesion was estimated to be intramucosal. Although the lesion met the indications for endoscopic resection, periodic endoscopic follow-up was performed due to the patient's advanced age and comorbidities. The mucosal GC invaded into the submucosa 3 years later, and finally progressed to advanced cancer 5 years after the initial examination. The patient died of tumor hemorrhage 6.4 years after the initial examination. In this case, mucosal GC progressed to advanced GC, eventually leading to the patient's death from GC. Early and appropriate treatment is required to prevent GC-related death.