CAUGHT BETWEEN ANCESTORS AND SPIRITS : A KOREAN MANSIN S HEALING KUT

Kendall, Laurel 한국문화인류학회 1977 韓國文化人類學 Vol.9 No.1

The Storyteller : Introduction to the Life History of a Korean Woman

Kendall, Laurel 경북대학교 사회과학연구소 1988 社會科學硏究 Vol.4 No.-

Fast Scan Cyclic Voltammetry Recordings in Humans during Neurosurgery: Challenges and Opportunities

Kendall H. Lee 대한의용생체공학회 2011 Biomedical Engineering Letters (BMEL) Vol.1 No.3

It is with great pleasure to congratulate the launch of the premier journal of “Biomedical Engineering Letters”, which is an official journal of the Korean Society of Medical and Biological Engineering. Biomedical engineering technology is one of the most crucial components in the interdisciplinary and translational research area. I believe this era will be the golden age of biomedical technology, applying the most advanced applications to scientific research. The launch of Biomedical Engineering Letters reflects this vision, and with its strong editorial board it will play a leading role opening up the biomedical engineering’s last frontier. Here, I briefly introduce the novel biomedical method of deep brain stimulation (DBS). DBS has been demonstrated to be an effective neurosurgical treatment for many neurological and psychiatric disorders including Parkinson’s disease, tremor,epilepsy, depression, and chronic pain. We have developed a novel intraoperative neurochemical monitoring device called wireless instantaneous neurotransmitter concentration sensor (WINCS) system, which combines digital telemetry with amperometry and fast-scan cyclic voltammetry (FSCV) for real-time neuro-chemical measurements at an implanted microelectrode. WINCS could detect neurotransmitters such as dopamine, adenosine, serotonin, glutamate, and histamine with micro second temporal resolution and high sensitivity. We have now utilized the system in rats, pigs, and in human Parkinson’s Disease (PD) and Essential Tremor (ET) patients during DBS neurosurgery. WINCS hardware is a micro-processor controlled, MRIcompatible,battery-powered instrument that combines Bluetooth® digital telemetry with FSCV and constant potential amperometry. The WINCS base-station software (WINCSware) controls the wireless patient module and processes the received data stream, and displays the results in nearly real time. The WINCS Electrode (WINCStrode) is based on an approved human extracellular tungsten electrophysiology electrode that was modified by the addition of a short section of carbon-fiber to enable FSCV recordings. To date, the WINCS hardware, WINCSware, and WINCStrode were used in rats, pigs, and in 15 human PD or ET Patients during clinical DBS neurosurgery. Leksell Model G Stereotactic headframe, MRI guided neuronavigation system was used for surgical targeting. Our protocol was approved by the Mayo Clinic IRB for human studies. Successful real-time analysis of wireless FSCV recordings from WINCS using the WINCStrode were performed both in a flow cell in vitro, rats, pigs, and in human PD and ET patients undergoing DBS neurosurgery. For FSCV,neurochemical data were transmitted by the WINCS hardware to the computer base station for presentation of a continuous three-dimensional color plot of sequential backgroundsubtracted voltammograms. Analysis of the voltammograms revealed signals consistent with measurements of dopamine efflux when the WINCStrode was placed in the caudate and adenosine efflux when placed in the VIM thalamus. Following WINCS recordings, the patients had good clinical response from the bilateral STN or VIM DBS electrodes, without complication. Our studies represent the successful feasibility and safety study using WINCS in animals and in humans. We believe the combination of these sophisticated in vivo techniques will provide important new insights into the neurobiological mechanisms of DBS action. Further, our results suggest that next generation DBS systems that couples digital telemetry with FSCV may be useful as the sensing component of a “smart” DBS device providing enhanced utility to human patients.

양성자와 중성자의 구조

Kendall, Henry W.,Panofsky, K.H. 이화여자대학교 사범대학 과학교육과 1972 과학교육 Vol.8 No.-

60년전 Ernest Rutherford는 α입자가 엷은 금속박에 의해 산란되는 것을 관찰하고 원자는 동질체가 아니라 작으나 무거운 양전하를 가진 핵과 그 둘레에 음전자를 가진 전자로 구성되었다고 결론 지었다. 그 후 여러 실험실에서 연구하던 물리학자들은 처음에는 원자의 구조, 다음에는 핵의 구조, 그리고 지금은 핵의 구성 요소인 양성자와 중성자의 구조를 실험하기 위하여(보다 큰 에너지를 가진 입자로) 산란 실험을 행하고 있다. 이들의 기본 핵 입자가 동질인 것인가? Stanford의 선형 가속기 센터에 있는 2마일 길이의 강력한 가속기로 가속시킨 21×10^9 eV의 에너지를 가진 원자로 한 최근의 많은 연구가 제시한 바에 의하면 그들의 크기는 원자의 크기보다 100,000배나 더 적을 것이라는 것이다.

Low Back Pain : Treatment and Prevention

Kendall, Nicholas A.S. Medical Publications Korea 1997 Medical Progress Vol.19 No.6

Dopamine Measurement during Prolonged Deep Brain Stimulation: A Proof-of-Principle Study of Paired Pulse Voltammetry

Kendall H. Lee,Seungleal Brian Paek,Emily Jane Knight,Su-Youne Chang,J. Luis Lujan,장동표,Kevin E. Bennet 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.1

Purpose Deep Brain Stimulation (DBS) has been effective in treating various neurological and psychiatric disorders;however, its underlying mechanism hasn’t been completely understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of DBS, due to its sub-second temporal resolution and direct identification of analytes. However, since DBS-like high frequency stimulation evokes neurotransmitter release as well as extracellular pH shift, it is hard to isolate the neurotransmitter signal from the complex environment. Here we demonstrate the efficacy of a modified FSCV technique, Paired Pulse Voltammetry (PPV), in detecting dopamine (DA) release in the caudate nucleus during long-term electrical stimulation of the medial forebrain bundle (MFB) in the rat. Methods Unlike traditional FSCV applying a single triangular waveform, PPV employs a binary waveform with a specific time gap (2.2 ms) in between the comprising pulses. DA measurement was performed with a carbon fiber microelectrode placed in the caudate nucleus and a twisted bipolar stimulating electrode in the MFB. PPV data was collected with the Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Results Using PPV, the detection of DA was evident throughout the long-term stimulation (5 minutes); however, without PPV,in vivo environmental changes including pH shift eventually obscured the characteristic oxidation current of DA at 0.6V. Conclusions These results indicate that PPV can be a valuable tool to accurately determine DA dynamics in a complex in vivo environment during long-term electrical stimulation.

소비하는 영혼들

Kendall, Laurel 한국문화인류학회 1998 韓國文化人類學 Vol.31 No.2

Korean Shamans in the Present Tense: Introduction

Laurel Kendall 서강대학교 종교연구소 2012 Journal of Korean Religions Vol.3 No.2

Mugam: The Dance in Shaman`s Clothing

LAUREL KENDALL The Academy of Korean Studies 1977 Korea Journal Vol.17 No.12

On the Problem of Material Religion and Its Prospects for the Study of Korean Religion

Laurel Kendall 서강대학교 종교연구소 2010 Journal of Korean Religions Vol.1 No.1

This paper argues that the “material turn” evident both in recent scholarly studies of EastAsian religion (and religious studies more generally) and within the discipline ofanthropology holds great promise for the study of Korean religions. The study of materialreligion raises questions about how aspects of the material world come to be regarded assacred, how they come to be regarded as empowered and agentive things, how devoteesengage material religion through embodied practice and visual regimes of understanding andvenerating, and how specific historic moments influence material religion. Anthropologybrings to the discussion an awareness of material objects as possible nodes of humanrelationships, relationships between humans and gods or other entities, and between humans,deities, positive and negative power, and the sacred things themselves. It raises questionsabout the production, maintenance, and proper disposal of sacred objects. It also bringsmagic back into the mix as a means of understanding some of the essentially religious wayscontemporary people contend with the quirkiness of the market and other uncertainties, andhow the modern commodity market itself accommodates the production, appropriation, andconsumption of sacred and magical goods.