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- 저자 : Kayode Ezekiel Adewole (검색결과 2 건)
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Exploring phytotherapeutic approach in the management of valproic acid-induced toxicity
Kayode Ezekiel Adewole,Alfred Francis Attah,Sharon Oluchi Osawe 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.2
The antiepileptic drug, valproic acid (VPA), also used for treating psychiatric disorders, is hampered by its toxicity. Its associated adverse effects include hepatotoxicity, nephrotoxicity, central nervous system (CNS) depression, respiratory failure, acute pancreatitis, thrombocytopenia, hyperammonaemia, bone marrow suppression, and teratogenicity. Currently, no antidotes exist for treating VPA toxicity and therapeutic management is majorly supportive while modifying drug disposition. The lack of effective treatment has prompted evaluating plant-derived products to manage this challenge since studies show their protective potential against drug-induced toxicities. This review investigates purported mechanisms and the protective capacity of plants products against VPA-induced toxicity. The compiled studies revealed that VPA causes hepatotoxicity, nephrotoxicity, ocular toxicity, teratogenicity and reproductive toxicity among others. Further findings highlighted the oxido-inflammatory and apoptotic pathway as crucial mechanisms of VPA-induced organ toxicities. Extracts of Apium graveolens L., Bacopa monniera, Green tea, Kaempferia parviflora, Korean red ginseng, Ocimum sanctum, Oryza sativa, Withania somnifera and plant-derived compounds, including diammonium glycyrrhizinate, sulforaphane, vitamin U, B6, E, diallyl trisulfide, curcumin, α-tocopherol, quercetin, piperine, resveratrol, hesperitin, thymoquinone, caffeic acid and asiatic acid exhibited protection against VPA-induced toxicities. From these observations, it is suggested that further studies should target evaluating more plant products as well as identifying and isolating specific compounds from such, and others demonstrating protective effect against toxicities induced by VPA.
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Ebenezer Tunde Olayinka,Ayokanmi Ore,Kayode Ezekiel Adewole,Oyepeju Oyerinde 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.3
The types and mechanisms of atrazine-metolachlor toxicity, an herbicide composed of atrazine (ATR) and metolachlor (MET), need to be further investigated. This study evaluated the toxic actions of ATR-MET by in vivo and in silico methods. Here, varying doses of ATR-MET were orally administered to rats once daily for twenty-one days using normal saline as control. Molecular docking was used to characterize the binding of ATR and MET with androgen receptor (AR) to predict their potential endocrine-disrupting effects, using testosterone as benchmark. ATR-MET-induced-testicular toxicity (reduced sperm motility, count, and daily sperm production and increased live/dead ratio) was accompanied with testicular oxidative stress (diminished level of reduced glutathione, activities of glutathione-S-transferase, superoxide dismutase and catalase and increased level of malondialdehyde). Furthermore, ATR-MET induced cardiovascular toxicity (increased levels of plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides) with concomitant induction of renal toxicity (increased plasma creatinine and urea levels), and hepatotoxicity (increased plasma bilirubin, alkaline phosphatase, acid phosphatase, alanine aminotransferase and aspartate aminotransferase). Binding energy and amino acid interactions from in silico study revealed that MET possessed endocrine-disrupting capacity. In conclusion, exposure to atrazine-metolachlor could promote cardiovascular, renal, hepatic, as well as reproductive impairment in experimental male albino rats.
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