Detection and Mapping of Rainfall Erosivity for Conservation Planning in Dry Valleys, the Eastern Desert, Egypt

Khaled Mohamed Darwish,W.a.m. Abdel Kawy,R. Zoelitz 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Lamotrigine Decreased Hippocampal Damage and Improved Vascular Risk Markers in a Rat Model of Pentylenetetrazole Induced Kindling Seizure

Haggag, Basma S.,Hasanin, Amany H.,Raafat, Mona H.,Kawy, Hala S. Abdel The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3

Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated with increased vascular risk, through impairment of the endogenous antioxidative ability which may trigger oxygen-dependent tissue injury. Lamotrigine (LTG) a non-enzyme-inducing AED has scarce information regarding its effects on oxidative stress. The present study aimed to study the possible modulation of vascular risk factors of epileptogenesis by LTG, in a rat model of kindling seizure induced by pentylenetetrazole (PTZ). Four groups of male Wister rats were used; vehicle control group, PTZ group (alternate day PTZ, 30 mg/kg, i.p), LTG/PTZ group (LTG 20 mg/kg/day p.o and alternate day PTZ) and LTG group. The study period was 5 weeks. Lipoproteins and total homocysteine (tHcy), malondialdehyde (MDA) and reduced glutathione (GSH) were measured. Aortic endothelial function study and histopathological examination of the rats' brains, aortas and coronaries were conducted. Serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), tHcy, MDA, GSH levels were significantly higher in epileptic rats than normal controls rats. A decrease in HDL-cholesterol with high atherosclerotic index was also demonstrated. The administration of LTG improved the PTZ-kindled seizures. It produced a significant decrease in TC, TG and LDL-cholesterol, MDA, aortic GSH and increase in HDL-cholesterol with no significant effect on serum GSH and tHcy levels. LTG improved endothelium-dependent relaxation, decreased hippocampal neurodegenerative changes and atherosclerotic changes of aortas and coronaries. LTG decreased seizures severity, hippocampal damage and improved vascular risk markers in this rat model of kindling seizures.

Lamotrigine Decreased Hippocampal Damage and Improved Vascular Risk Markers in a Rat Model of Pentylenetetrazole Induced Kindling Seizure

Basma S Haggag,Amany H Hasanin,Mona H Raafat,Hala S Abdel Kawy 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3

Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated withincreased vascular risk, through impairment of the endogenous antioxidative ability which may triggeroxygen-dependent tissue injury. Lamotrigine (LTG) a non-enzyme-inducing AED has scarce informationregarding its effects on oxidative stress. The present study aimed to study the possible modulationof vascular risk factors of epileptogenesis by LTG, in a rat model of kindling seizure induced bypentylenetetrazole (PTZ). Four groups of male Wister rats were used; vehicle control group, PTZ group(alternate day PTZ, 30 mg/kg, i.p), LTG/PTZ group (LTG 20 mg/kg/day p.o and alternate day PTZ)and LTG group. The study period was 5 weeks. Lipoproteins and total homocysteine (tHcy), malondialdehyde(MDA) and reduced glutathione (GSH) were measured. Aortic endothelial function studyand histopathological examination of the rats’ brains, aortas and coronaries were conducted. Serumtotal cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), tHcy, MDA,GSH levels were significantly higher in epileptic rats than normal controls rats. A decrease inHDL-cholesterol with high atherosclerotic index was also demonstrated. The administration of LTGimproved the PTZ-kindled seizures. It produced a significant decrease in TC, TG and LDL-cholesterol,MDA, aortic GSH and increase in HDL-cholesterol with no significant effect on serum GSH and tHcylevels. LTG improved endothelium-dependent relaxation, decreased hippocampal neurodegenerativechanges and atherosclerotic changes of aortas and coronaries. LTG decreased seizures severity,hippocampal damage and improved vascular risk markers in this rat model of kindling seizures.

Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia

El-Gendy Fady Mohamed,Shehata Amira M.F.,El-Kawy Esam Awad Abd,El-Hawy Mahmoud Ahmed 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3

Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved in many autoimmune diseases.Purpose: Here we aimed to measure changes in PD-1 expression and serum interferon-γ (IFN-γ) levels before and 1 month after treatment in pediatric patients with newly diagnosed ITP.Methods: We measured PD-1⁺ CD4⁺ T cells percentages using flow cytometry and the serum IFN-γ levels by enzyme-linked immunosorbent assay in 40 pediatric patients with ITP and 20 healthy controls.Results: Compared with healthy controls, the PD-1⁺ CD4⁺ T cells percentages and serum IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy. A correlation study revealed that PD-1⁺ CD4⁺ T cells percentage was negatively associated with platelet count and positively associated with IFN-γ level in patients with ITP. Furthermore, serum IFN-γ levels were significantly decreased in patients after treatment, but no significant change was detected in the percentage of PD-1⁺ CD4⁺ T cells before or 1 month after therapy.Conclusion: PD-1⁺ CD4⁺ T cells expression and IFN-γ levels were increased in patients with ITP. These preliminary data suggest a potential role of PD-1⁺ CD4⁺ T cells as mediators of ITP. We also found a correlation between PD-1⁺ CD4⁺ T cells and both platelet counts and IFN-γ levels. These findings suggest a potential role of PD-1⁺ CD4⁺ T cells and IFN-γ in the pathogenesis of ITP. Further studies investigating PD-1 expression in different T-cell subsets, serum IFN-γ concentrations, and antiplatelet antibodies levels over a longer duration after therapy initiation could delineate the precise role of PD-1 in ITP pathogenesis. Consequently, novel nontraditional therapeutic strategies for ITP patients may become available.

LIQUID-PHASE OXIDATION OF CYCLOHEXANE USING Co-P-MCM-41 CATALYST

Liu, Shaoyong,Liu, Zhepeng,Kawi, Sibudjing 한국화학공학회 1998 Korean Journal of Chemical Engineering Vol.15 No.5

Highly active mesoporous chromium silicate catalysts in side-chain oxidation of alkylaromatics

Selvaraj, M.,Park, D.-W.,Kim, I.,Kawi, S.,Ha, C. S. The Royal Society of Chemistry 2012 Dalton Transactions Vol.41 No.46

<P>We approach a green method in the production of alkylaromatic ketones over hexagonally ordered mesoporous CrSBA-15 catalysts, which were used, in green routes, in the liquid-phase oxidation of alkylaromatics. A promising chemical treatment method was used with ammonium acetate solution to remove the toxic nature of non-framework chromium oxides deposited on the surface of calcined CrSBA-15(8), and the obtained green mesoporous CrSBA-15(8) catalyst was used to find its catalytic activity while the recyclability of mesoporous CrSBA-15 catalysts was also studied. Particularly, the mesoporous CrSBA-15 catalysts synthesized with a variety of chromium contents were extensively used in the production of acetophenone (AP&z.dbd;O) with various reaction parameters. On the basis of all catalytic results, the mesoporous CrSBA-15(8) catalyst produced a higher selectivity of alkylaromatic ketones (76–100%) as compared to other CrSBA-15 catalysts and was found to be a highly active, recyclable and promising heterogeneous catalyst for selective synthesis of alkylaromatic ketones.</P> <P>Graphic Abstract</P><P>Mesostructured green mesoporous CrSBA-15 catalyst has exceptional catalytic activity in oxidation of alkylaromatics. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2dt31571h'> </P>

Selective synthesis of vitamin K₃ over mesoporous NbSBA-15 catalysts synthesized by an efficient hydrothermal method

Selvaraj, M.,Park, D.-W.,Kim, I.,Kawi, S.,Ha, C. S. The Royal Society of Chemistry 2012 Dalton Transactions Vol.41 No.32

<P>Well hexagonally ordered NbSBA-15 catalysts synthesized by an efficient hydrothermal method were used, for the first time, for the selective synthesis of vitamin K<SUB>3</SUB> by liquid-phase oxidation of 2-methyl-1-naphthol (2MN1-OH) under various reaction conditions. The recyclable NbSBA-15 catalysts were also reused to find their catalytic activities. To investigate the leaching of non-framework niobium species on the surface of silica networks, the results of original and recyclable NbSBA-15 catalysts were correlated and compared. To find an optimum condition for the selective synthesis of vitamin K<SUB>3</SUB>, the washed NbSBA-15(2.2pH) was extensively used in this reaction with various reaction parameters such as temperature, time and ratios of reactant (2M1N-OH to H<SUB>2</SUB>O<SUB>2</SUB>), and the obtained results were also demonstrated. Additionally, the liquid-phase oxidation of 2M1N-OH was carried out with different solvents to find the best solvent with a good catalytic activity. Based on the all catalytic studies, the vitamin K<SUB>3</SUB> selectivity (97.3%) is higher in NbSBA-15(2.2pH) than that of other NbSBA-15 catalysts, and the NbSBA-15(2.2pH) is found to be a highly active and eco-friendly heterogeneous catalyst for the selective synthesis of vitamin K<SUB>3</SUB>.</P> <P>Graphic Abstract</P><P>Mesostructured NbSBA-15 catalysts were used, in novel green routes, for the synthesis of vitamin K<SUB>3</SUB> from 2-methyl-1-naphthol. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2dt31096a'> </P>

Selective synthesis of 6,8-di-<i>t</i>-butylated flavan over Zn–Al containing mesoporous silica catalysts

Selvaraj, M.,Sinha, P. K.,Park, D.-W.,Kim, Il,Kawi, S.,Ha, C. S. The Royal Society of Chemistry 2012 Dalton Transactions Vol.41 No.46

<P>We demonstrate a much green synthesis method for highly selective synthesis of 6,8-di-<I>t</I>-butylated flavan (6,8-DTBF) by liquid phase alkylation of 2,4-di-<I>t</I>-butylphenol (2,4-DTBP) with cinnamyl alcohol (Cin-OH) over mesoporous Zn–Al–MCM-41 catalysts synthesized under direct basic hydrothermal method. The main alkylated product, 6,8-DTBF is importantly used as an intermediate in the manufacture of biosynthetic organic compounds. The recyclable mesoporous Zn–Al–MCM-41 catalysts have also been reused in this reaction to study their catalytic activities. The influences of various reaction parameters such as temperature, time, ratios of reactant (2,4-DTBP-to-Cin-OH) have been extensively investigated for the synthesis of 6,8-DTBF. In addition, dimethyl sulfoxide (DMSO) has also been used as a solvent in this catalytic reaction. The mesoporous Zn–Al–MCM-41(75) gives excellent catalytic activity with 6,8-DTBF selectivity (86.0%) and 2,4-DTBP conversion (63.1%), and these catalytic results have also compared with that obtained using other mesoporous and microporous catalysts. On the basis of catalytic activity obtained by using the all catalysts, the Zn–Al–MCM-41(75) catalyst is found to be a highly active, recyclable and eco-friendly heterogeneous catalyst in the liquid-phase alkylation of 2,4-DTBP.</P> <P>Graphic Abstract</P><P>Zn–Al–MCM-41(75) catalyst is found to be a highly active, recyclable and eco-friendly green catalyst in the liquid-phase alkylation of 2,4-DTBP. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2dt31409f'> </P>