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      • KCI등재

        Comparison of Automatic and Human Evaluation of L2 Texts in Czech

        Svatava Škodová,Kateřina Rysová,Magdaléna Rysová 한국슬라브어학회 2019 슬라브어연구 Vol.24 No.1

        In this paper, we introduce an experimental probe comparing how texts written by non-native speakers of Czech are evaluated by a software application (computer program) EVALD and by teachers of Czech as a foreign language. The hypothesis for the probe was that teachers, even if they are given structured instruction for evaluation and go through the standardization process, are not able to reach satisfactory results and to agree on the same evaluation, which depreciates the whole text evaluation process. This is a problem especially for objective assessment during certificated exams such as the Exam for Permanent Residence. A group of 44 teachers of Czech as a foreign language who underwent special training and the computer program evaluated 2 texts from the point of view of relevant features of the A1–C1 levels established by the Common European Framework of Reference for Languages. The task included evaluation of the overall level of the texts and evaluation of specific aspects of the texts: punctuation, morphology, lexis, syntax and coherence. We compare the evaluation of the text among the teachers and the teachers with the computer program. In the general evaluation, only 41% of persons agreed on the same level for text A and 50% for text B (we describe and interpret the agreement in the evaluation of orthography, morphology, syntax, lexis and coherence below). The lowest rate of inter-evaluator agreement was in orthography – 38% for text A and 40% for text B. In morphology, 59% of persons agreed on the same level for text A and 61% for text B. We further compared human and automatic agreement on the evaluation. 41% of teachers agreed with the program on the evaluation of text A and 50% of text B. Again, we also compared the results on the particular language and text levels. Our results clearly show that human evaluation is rather inconsistent and it would be advisable to use automatic evaluation in cases where consistency and high agreement is desired.

      • Association of HLA Variants with Sarcoidosis in Koreans

        ( Ho Jeong Kim ),( Kateřina Sikorová ),( Martin Petřek ),( Veronika Žižková ),( Su-jin Moon ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

        Background Sarcoidosis is the immune-mediated disease and the role of HLA polymorphisms was implicated. However, the association between HLA polymorphisms and sarcoidosis in Koreans has not yet been investigated. The aim of this study was to investigate the role of HLA variation in the etiopathogenesis of sarcoidosis in Koreans using next-generation sequencing. Methods In this study, 63 patients diagnosed with sarcoidosis at Asan Medical Center, Seoul, South Korea, were enrolled. The diagnosis of sarcoidosis was based on the World Association of Sarcoidosis and Other Granulomatous Diseases (WASOG) Assessment Instrument. We performed genotyping of 7 HLA loci (HLA-A, -B, -C, DRB1, -DQA1, -DQB1, -DPB1) by Omixon Holotype™ kit and Twin software™. HLA allele frequency of sarcoidosis patients was compared with data on healthy Koreans from the allelic frequency database (http://allelefrequencies.net, South Korea pop1 and pop3). Results Of total subjects, the mean age was 45.8 years, and 33.3% were men. The allele frequencies were different between the sarcoidosis cases and the healthy population, especially in HLA-class II. Alleles HLA-DQA1*05:08; DQB1*03:01 and DRB1*12:01 showed significantly higher frequencies in patients with sarcoidosis compared with healthy subjects (Figure 1). By contrast, alleles HLA DQA1*01:02; DQB1*03:02 and DRB1*13:02 were more common in healthy subjects than sarcoidosis cases. Alleles HLA-A*31:01; A*02:06 and DQB1*06:01 were significantly associated with treated patients. Conclusions In this pilot study, we found some sarcoidosis-associated variants in Koreans, especially in the HLA-class II. Korean patients showed different HLA variants compared with that in Western patients.

      • Association of Immune Related Genes with Sarcoidosis in Korean Population

        ( Hee-young Yoon ),( Martin Petřek ),( Kateřina Sikorová ),( Adam Strnad ),( Lenka Kocourková ),( Su-jin Moon ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

        Background Sarcoidosis is the immune-mediated disease, characterized by the formation of non-caseating epithelioid granulomas. Genetic factors affecting immune and inflammatory reactions have important role in pathophysiology of sarcoidosis. However, genetic factors of sarcoidosis in Koreans were not well known. Thus, we investigated the variability in polymorphic variants in genes involved in inflammation, immune system and granulomas development. Methods Twenty Single Nucleotide Polymorphisms (SNP) in 141 Korean patients with sarcoidosis were genotyped using multiplexed MassARRAY® iPLEX assay based on MALDI-TOF mass spectrometry (Agena Bioscience, CA, USA). SNPs frequency data in patients were compared with SNPs frequencies of healthy East Asia population from a database (ensembl.org). Each SNP was tested for HWE (> 0.01). Association was determined using allelic model with Fischer’s exact test with Bonferroni’s correction for multiple comparisons. Results We found six SNPs associated with sarcoidosis after Bonferroni’s correction. Of them, three (TGF-β3 rs3917200, TAP2 rs3819717, and HLA-DRB1*03:01 rs2040410) were protective factors (odds ratio [OR]< 1. while other three) (TGF-β2 rs1891467, HLADRA, HLA-DRB5 rs1964995, and HLA-DQA1 rs2187668) were risk factors (OR >1) (Table 1). In addition, SNP rs2040410 HLADRB1* 03:01 was a protective factor extrapulmonary manifestation of sarcoidosis (OR: 0.319 [0.154-0.661], pcorr=0.006). Conclusions We report SNPs in TAP2, TGF-β and HLA class II genes associated with sarcoidosis in Koreans. Further work in extended cohort is required to validate these findings and investigate their possible relationship with clinical course of sarcoidosis.

      • KCI등재

        Simple Fabrication of Polycaprolactone-co-lactide Membrane with Silver Nanowires: Synthesis, Characterization and Cytotoxicity Studies

        Zuzana Šimonová,Ludmila Porubová,Adam Verner,Roman Gabor,Zuzana Vilamová,Edmund Dobročka,Miroslav Cieslar,Veronika Krbečková,Kateřina Peterek Dědková,Ladislav Svoboda,Jiří Bednář,Richard Dvorský,Jana 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11

        Our simple technique of polymer/metal-based material preparation produces very promising material, and weoutline that this material can be suitable for the potential wound healing multilayered dressing. In our research we focused onthese main issues: (1) the preparation of silver nanowire-like structures using gallic acid (GA); (2) direct silver nanowire-likestructure crystallization of co-polymer L-lactide and ε-caprolactone (PLCL) electrospun fiber and (3) evaluation of thematerial cytotoxicity on the Vero cell line. Synthesized silver nanowire-like width varied from 30 to 100 nm and thehexagonal particles had sizes from 80 to 300 nm. The detected structures were crystalline cubic silver and were similarlysynthesized during both batch synthesis and direct synthesis on the PLCL fibers. The amount of the silver spread within thefibrous membrane was approximately 1.1 wt. % in the sample, moreover, the silver incorporation had no influence on thepolymer structure, which was confirmed by FTIR measurement. The cytotoxicity testing estimated that cell survivalincreased with decreased concentration of GA and silver in the PLCL matrix and the silver-based sample in 50 % MTTextraction concentration maintained required non-cytotoxic properties.

      • SCISCIESCOPUS

        Derivations of the band-importance function: A cross-procedure comparison.

        Jin, In-Ki,Kates, James M,Lee, Kyoungwon,Arehart, Kathryn H American Institute of Physics for the Acoustical S 2015 Journal of the Acoustical Society of America Vol.138 No.2

        <P>The purpose of this study was to compare band-importance functions (BIFs) derived by two different procedures. Intelligibility data from native speakers of Korean were used. BIFs were derived using an established procedure reported by Studebaker and Sherbecoe [J. Speech Lang. Hear. Res. 34, 427-438 (1991)] and by a recently published method reported by Kates [J. Acoust. Soc. Am. 134(5), EL459-EL464 (2013)]. The BIFs produced by the two different procedures were similar. These results indicate that the BIF calculation procedure by Kates is accurate for sentences as well as for the monosyllables used in its derivation.</P>

      • KCI등재

        Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster

        Kate E. Yu,김도형,김용인,Walton D. Jones,J. Eugene Lee 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.2

        Animals use their odorant receptors to receive chemical information from the environment. Insect odorant recep-tors differ from the G protein-coupled odorant receptors in vertebrates and nematodes, and very little is known about their protein–protein interactions. Here, we introduce a mass spectrometric platform designed for the large-scale analysis of insect odorant receptor protein–protein interactions. Using this platform, we obtained the first Orco interactome from Drosophila melanogaster. From a total of 1,186 identified proteins, we narrowed the interaction candidates to 226, of which only two-thirds have been named. These candidates include the known olfactory proteins Or92a and Obp51a. Around 90% of the proteins having published names likely function inside the cell, and nearly half of these intracellular proteins are associated with the endomembrane system. In a basic loss-of-function electrophysiological screen, we found that the disruption of eight (i.e., Rab5, CG32795, Mpcp, Tom70, Vir-1, CG30427, Eaat1, and CG2781) of 28 randomly selected candidates affects olfactory responses in vivo. Thus, because this Orco interactome includes physiologically meaningful candidates, we anticipate that our platform will help guide further research on the molecular mechanisms of the insect odorant receptor family.

      • SSCISCOPUSKCI등재
      • KCI등재

        Is All Well? Shakespeare's Play with narratives

        Kate McLuskie(케이트 맥러스키) 한국셰익스피어학회 2005 셰익스피어 비평 Vol.41 No.3

        본 논문은 셰익스피어의 작품에 담겨있는 다양한 서술의 복잡한 상호관계를 고찰하면서, 작품의 상호 대립적인 서술 사이에 존재하는 변증법적인 관계와 이들이 어떻게 무대에서 재현되며 작품의 언어에 공시적인 성격을 부여하는지 분석하려는 것이다. 본인은 특히 『끝이 좋으면 다 좋다』를 중점적으로 고찰하면서 작품의 서술방식이 어떻게 작품 해석의 조건에 영향을 주는지 밝혀보려 한다. 이 논문에서 다루고 있는 중심적인 내용은 다음의 문제들에 대한 응답의 형태가 될 것이다. 인물들의 행동 이전에 서술이 어떻게 나타나며, 그러한 서술이 행동을 정당화하는가? 서술의 정서적, 사회적 결과 사이에 어떤 관계가 있는가? 서술이 그 자체로 어떻게 문화 시장의 변화가 드러내는 여러 층화를 암시할 수 있는가? 셰익스피어의 작품은 다양한 이야기와 더불어 그러한 이야기를 서술하는 방식이 복잡하여 동기와 인물의 성격에 대한 복잡한 추론을 가능케 하며, 작품에 대한 다층적인 해석을 동시에 가능케 하는 특징을 가지고 있다.

      • KCI등재후보

        국제물품매매계약에 관한 국제연합협약의 적용범위

        Kate Lannan 국제거래법학회 2005 國際去來法硏究 Vol.14 No.2

        국제물품매매계약에 관한 국제연합협약(CISG) 제1편 제1장 제1조 내지 제6조는 명확하고 논리적으로 협약의 적용범위를 설정하고 있다. 그러나 법원은 이와 관련하여 계속해서 흥미 있는 논점을 제기하고 있다. 법학자들도 일정한 경우 CISG의 적용여부에 대한 의문을 제기하고 있다. 본 논문에서는 조문별로 그 해석과 적용상의 문제점을 살펴보고자 한다. 제1조와 관련하여서는 CISG의 적용범위, 매매계약, 물품, 계약당사자 및 영업소의 문제를 다루었다. 제2조에서는 소비자의 물품매매, 경매에 의한 매매, 강제집행 그 밖의 법령에 의한 매매, 주식·지분·투자증권·유통증권 또는 통화의 매매, 선박·소선·부선·항공기의 매매, 전기의 매매와 같이 CISG가 적용되지 않는 경우를 제3조에서는 물품을 제조 또는 생산하여 공급하는 계약의 경우와 물품을 공급하는 당사자의 의무의 주된 부분이 노무 그 밖의 서비스의 공급에 있는 계약의 경우를 살펴보았다. 제4조와 관련하여서는 계약당사자, 매매계약의 성립, 계약과 관행의 유효성, 매매된 물품의 소유권에 관하여 계약이 미치는 효력, 입증책임에 대하여 알아보았다. 제5조에서는 물품으로 인하여 발생한 사람의 사망 또는 상해에 대한 매도인의 책임에 대한 적용 예외를 살펴보았다. 제6조와 관련해서는 당사자간의 합의에 의한 협약의 적용배제에 대하여 논의하였다.

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