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      • < 구두-C-05 > Durability of Bamboo Oriented Strand Board against Insect, Fungi, and Weather

        ( Fauzi Febrianto ),( Muhammad Anchu Kastian Asmur ),( Sena Maulana ),( Dini Lestari ),( M Qola A Damanik ),( Elis Nina Herliyana ),( Nam Hun Kim ) 한국목재공학회 2018 한국목재공학회 학술발표논문집 Vol.2018 No.1

        Bamboo oriented strand board (BOSB) is composite board composed of thin bamboo strand that was glued and hot pressed for structural application. In exterior application, BOSB will interact directly with deterioration factors such as physical (weathering) and biology (decay and powder post beetles). The objectives were to evaluate the physical, mechanical and durability of BOSB before and after baited to white rot decay Schizophyllum commune and powder post beetles, and before and after exposure to natural weathering. Prior to be mixed with PF adhesive, the strands were steam pre-treated in closed chamber at certain conditions with or without rinsed by distilled water and NaOH 1% solution. PF adhesive in amount of 8% and 1% of wax based on OD weight of strand were used. The ratio for face, core and back layers of BOSB were set at 1:1:1. It is clear that the physical, mechanical and durability against fungi, insect and natural weathering of BOSB were much influenced by steam treatment. Gradually, during 6 months exposure to natural weather the physical and mechanical properties of BOSB dropped significantly. Steam treatment on bamboo strand improved the physical, mechanical and durability properties of BOSB. Steam treatment followed by washing with NaOH 1% gave the best results on all parameters measured. Steam treatment followed by washing with NaOH 1% after exposure for 6 months had MOE and MOR parallel to grain direction fulfilled CSA 0437.0 (Grade 0-1) standard. BOSB prepared from steam treatment followed by washing with 1% NaOH solution belongs to 2nd grades on fungi resistance.

      • Combination of Potassium Pentagamavunon-0 and Doxorubicin Induces Apoptosis and Cell Cycle Arrest and Inhibits Metastasis in Breast Cancer Cells

        Putri, Herwandhani,Jenie, Riris Istighfari,Handayani, Sri,Kastian, Ria Fajarwati,Meiyanto, Edy Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5

        A salt compound of a curcumin analogue, potassium pentagamavunon-0 (K PGV-0) has been synthesized to improve solubility of pentagamavunon-0 which has been proven to have anti-proliferative effects on several cancer cells. The purpose of this study was to investigate cytotoxic activity and metastasis inhibition by K PGV-0 alone and in combination with achemotherapeutic agent, doxorubicin (dox), in breast cancer cells. Based on MTT assay analysis, K PGV-0 showed cytotoxic activity in T47D and 4T1 cell lines with $IC_{50}$ values of $94.9{\mu}M$ and $49.0{\pm}0.2{\mu}M$, respectively. In general, K PGV-0+dox demonstrated synergistic effects and decreased cell viability up to 84.7% in T47D cells and 62.6% in 4T1 cells. Cell cycle modulation and apoptosis induction were examined by flow cytometry. K PGV-0 and K PGV-0+dox caused cell accumulation in G2/M phase and apoptosis induction. Regarding cancer metastasis, while K PGV-0 alone did not show any inhibition of 4T1 cell migration, K PGV-0+dox exerted inhibition. K PGV-0 and its combination with dox inhibited the activity of MMP-9 which has a pivotal role in extracellular matrix degradation. These results show that a combination of K PGV-0 and doxorubicin inhibits cancer cell growth through cell cycling, apoptosis induction, and inhibition of cell migration and MMP-9 activity. Therefore, K PGV-0 may have potential for development as a co-chemotherapeutic agent.

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