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Kim, Kangmin,Park, Suhyung,Park, Jeong Hwan,Cho, Won-Sang,Kim, Hyoun-Ee,Lee, Sung-Mi,Kim, Jeong Eun,Kang, Hyun-Seung,Jang, Tae-Sik The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.6
Objective : Biodegradable poly-L-lactic acid (PLLA) with a highly biocompatible surface via tantalum (Ta) ion implantation can be an innovative solution for the problems associated with current biodegradable stents. The purpose of this study is to develop a Taimplanted PLLA stent for clinical use and to investigate its biological performance capabilities. Methods : A series of in vitro and in vivo tests were used to assess the biological performance of bare and Ta-implanted PLLA stents. The re-endothelialization ability and thrombogenicity were examined through in vitro endothelial cell and platelet adhesion tests. An in vivo swine model was used to evaluate the effects of Ta ion implantation on subacute restenosis and thrombosis. Angiographic and histologic evaluations were conducted at one, two and three months post-treatment. Results : The Ta-implanted PLLA stent was successfully fabricated, exhibiting a smooth surface morphology and modified layer integration. After Ta ion implantation, the surface properties were more favorable for rapid endothelialization and for less platelet attachment compared to the bare PLLA stent. In an in vivo animal test, follow-up angiography showed no evidence of in-stent stenosis in either group. In a microscopic histologic examination, luminal thrombus formation was significantly suppressed in the Ta-implanted PLLA stent group according to the 2-month follow-up assessment (21.2% vs. 63.9%, p=0.005). Cells positive for CD 68, a marker for the monocyte lineage, were less frequently identified around the Ta-implanted PLLA stent in the 1-month follow-up assessments. Conclusion : The use of a Ta-implanted PLLA stent appears to promote re-endothelialization and anti-thrombogenicity.
〈논문〉 ZnO 나노입자 삽입을 이용한 유기태양전지 효율 향상
김강민(Kangmin Kim),정부영(Booyoung Jung),김정원(Jungwon Kim),김우철(Woochul Kim) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
In organic photovoltaics, the thickness of active layer needs to be thick to absorb enough light, whereas the thickness better to be thin for efficient charge separation, i.e., small exciton diffusion length. There is a trade-off between thickness increase for enough light absorption and thickness decrease for efficient charge separation. The optimum thickness is around 100㎚ in previous works[1, 2]. In our research, by adapting the nonmetal ZnO nanoparticles, we scatter the light thereby effectively increase the light absorption. This results in increasing the energy conversion efficiency.
Kim, Kangmin,Yadav, Dhananjay,Cho, Min Elsevier 2019 Microbial pathogenesis Vol.135 No.-
<P><B>Abstract</B></P> <P>Norovirus is a highly infectious human pathogen that causes acute foodborne diseases worldwide. As global diet patterns have begun to incorporate a higher consumption of fresh agricultural products, the internalization of norovirus into plants has emerged as a potential threat to human health. Here, we demonstrated that murine norovirus (MNV1) was internalized into <I>Arabidopsis</I> in multiple phases, and this internalization was correlated with <I>Arabidopsis</I> innate immunity responses. Under hydroponic conditions, continuous treatment of MNV1 retarded root growth and facilitated flower development of <I>Arabidopsis</I> without causing necrotic lesions. Examination of viral titers and RNA levels revealed that MNV1 was internalized into <I>Arabidopsis</I> in at least three different phases. In response to MNV1 treatment, the <I>Arabidopsis</I> defensive marker <I>PR1</I> (a salicylic acid signaling marker) was transiently up-regulated at the early stage. <I>PDF1.2</I>, a jasmonic acid signaling marker, exhibited a gradual induction over time. Noticeably, <I>Arabidopsis RNS1</I> (T2 ribonuclease) was rapidly induced by MNV1 and exhibited anti-correlation with the internalization of MNV1. Exposure to recombinant <I>Arabidopsis</I> RNS1 protein reduced the viral titers and degraded MNV1 RNA <I>in vitro</I>. In conclusion, the internalization of MNV1 into <I>Arabidopsis</I> was fluctuated by mutual interactions that were potentially regulated by <I>Arabidopsis</I> immune systems containing <I>RNS1</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MNV1 treatment altered the root growth and floral transition of <I>Arabidopsis</I>. </LI> <LI> The internalization of MNV1 into <I>Arabidopsis</I> occurred in multiple phases. </LI> <LI> Plant immune responses potentially modulated the MNV1 internalization. </LI> <LI> <I>Arabidopsis</I> ribonuclease <I>RNS1</I> negatively regulated MNV1. </LI> </UL> </P>
Kim, Kangmin,Park, Sung-Hee,Chae, Jong-Chan,Soh, Byoung Yul,Lee, Kui-Jae Published by Elsevier/North Holland on behalf of t 2014 FEMS microbiology letters Vol.355 No.2
<P>1-Aminocyclopropane-1-carboxylate (ACC) deaminase is commonly produced by plant growth-promoting rhizobacteria (PGPR) and has been suggested to facilitate the growth and stress tolerance of hosts via a reduction in levels of ethylene. However, the regulatory mechanism of ACC deaminase (AcdS) protein within host plant cells is largely unknown. Here, we demonstrated beneficial effects and post-translational modification of PGPR-originated AcdS proteins in plants. Compared with the wild-type, transgenic Arabidopsis expressing the Pseudomonas fluorescens acdS (PfacdS) gene displayed increased root elongation and reduced sensitivity to 10 μM exogenous ACC, an ethylene precursor. Arabidopsis expressing PfacdS also showed increased tolerance to high salinity (150 mM NaCl). PfAcdS proteins accumulated in transgenic Arabidopsis were rapidly degraded, which was potentially mediated by the 26S proteasome pathway. The degradation of PfAcdS was alleviated in the presence of exogenous ACC. In conclusion, our data suggest that the plant growth-promoting effects of bacterial AcdS proteins are potentially modulated via protein turnover inside the host plant cells. Such post-translational modification plays a physiological role in the mutualistic interactions between microorganisms and plants in the rhizospheric and/or endospheric niche.</P>