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MafB negatively regulates RANKL-mediated osteoclast differentiation
Kim, Kabsun,Kim, Jung Ha,Lee, Junwon,Jin, Hye Mi,Kook, Hyun,Kim, Kyung Keun,Lee, Soo Young,Kim, Nacksung American Society of Hematology 2007 Blood Vol.109 No.8
<B>Abstract</B><P>Receptor activator of nuclear factor κB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors. Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation. Expression levels of MafB are significantly reduced by RANKL during osteoclastogenesis. Overexpression of MafB in bone marrow-derived monocyte/macrophage lineage cells (BMMs) inhibits the formation of TRAP+ multinuclear osteoclasts, but phagocytic activity of BMMs is retained. Furthermore, overexpression of MafB in BMMs attenuates the gene induction of NFATc1 and osteoclast-associated receptor (OSCAR) during RANKL-mediated osteoclastogenesis. In addition, MafB proteins interfere with the DNA-binding ability of c-Fos, Mitf, and NFATc1, inhibiting their transactivation of NFATc1 and OSCAR. Furthermore, reduced expression of MafB by RNAi enhances osteoclastogenesis and increases expression of NFATc1 and OSCAR. Taken together, our results suggest that MafB can act as an important modulator of RANKL-mediated osteoclastogenesis.</P>
( Junwon Kim ),( Jang Hun Kim ),( Jong Hyun Kim ),( Taek-hyun Kwon ),( Haewon Roh ) 대한외상학회 2019 大韓外傷學會誌 Vol.32 No.4
Purpose: Cranioplasty (CP) is often required for survival after decompressive craniectomy. Several materials, including autologous bone and various artificial materials, have been introduced for CP, but it remains unclear which material is best for CP. This study aimed to explore differences in complications between patients who underwent CP using an autologous bone flap versus a three-dimensional (3D) titanium mesh and to identify significant risk factors for post-CP complications. Methods: In total, 44 patients were enrolled in this study and divided into two groups (autologous bone vs. 3D titanium mesh). In both groups, various post-CP complications were evaluated. Through a comparative analysis, we aimed to identify differences in complications between the two groups and, using binary logistic analysis, to determine significant factors associated with complications after CP. Results: In the autologous bone flap group, there were three cases of surgical infection (3/24, 12.5%) and 11 cases of bone flap resorption (BFR) (11/24, 45.83%). In the 3D titanium mesh group, there was only one case of surgical infection (1/20, 5%) and 11 cases of various complications, including mainly cosmetic issues (11/20, 55%). A subgroup risk factor analysis of CP with an autologous bone f lap showed no risk factors that predicted BFR with statistical significance, although a marginal association was found between larger bone flaps and BFR (odds ratio [OR]=1.037, p=0.090). In patients treated with a 3D titanium mesh, multivariate analysis revealed that only the existence of a ventriculo-peritoneal shunt system was strongly associated with overall post-CP complications (OR=18.66, p=0.021). Conclusions: Depending on which material was used, different complications could occur, and the rate of complications was relatively high in both groups. Hence, the material selected for CP should be selected based on individual patients’ conditions.
강태웅(Taewoong Kang),김재원(Jae-Won Kim),반건호(Geon Ho Bahn),송숙형(Sook Hyung Song),김준원(Junwon Kim),김지훈(Ji-Hoon Kim),김윤정(Yoon-Jung Kim),김의정(Eui-Jung Kim),김태호(Tae-Ho Kim),양수진(Su-Jin Yang),양재원(Jaewon Yang),이소영(S 대한소아청소년정신의학회 2015 소아청소년정신의학 Vol.26 No.4
Objectives:Symptoms of attention-deficit hyperactivity disorder (ADHD) during childhood may persist into adulthood. This study included the development and validation process of the Korean Adult ADHD Rating Scale (K-AARS), which was developed for screening and monitoring treatment of adults with ADHD. Methods:Preliminary questionnaires of the K-AARS were based on the reviews of previous adult ADHD scales and clinical experiences of the board certified child and adolescent psychiatrists in Korea. For this study, 136 adults (18–50 years old) with inattention, hyperactivity and/or impulsivity symptoms were enrolled as ADHD subjects, and compared with 406 control subjects (18–50 years old) without ADHD symptoms. Construct validity was examined using explorative factor analysis and Cronbach’s alpha to obtain internal reliability coefficients. Concurrent validity was evaluated by comparison with the Conners’ Adult ADHD Rating Scale (CAARS). Results:An explorative factor analysis showed that the K-AARS had 8 factors (inattention, hyperactivity, impulsivity, antisocial personality disorder/conduct disorder/oppositional defiant disorder, impairment, driving, emotional dysregulation, disorganization). K-AARS was highly reliable in terms of internal consistency (Cronbach’s alpha 0.77–0.95) and correlation between factors (0.57–0.86). Concurrent validity with the CAARS and discriminant validity were statistically significant. Conclusion:The K-AARS is a valid and reliable measure for assessment of Korean adults with ADHD.
Silibinin inhibits osteoclast differentiation mediated by TNF family members
Kim, Jung Ha,Kim, Kabsun,Jin, Hye Mi,Song, Insun,Youn, Bang Ung,Lee, Junwon,Kim, Nacksung Springer-Verlag 2009 Molecules and cells Vol.28 No.3
<P>Silibinin is a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), with known hepatoprotective, anticarcinogenic, and antioxidant effects. Herein, we show that silibinin inhibits receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis from RAW264.7 cells as well as from bone marrow-derived monocyte/macrophage cells in a dose-dependent manner. Silibinin has no effect on the expression of RANKL or the soluble RANKL decoy receptor osteoprotegerin (OPG) in osteoblasts. However, we demonstrate that silibinin can block the activation of NF-κB, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein (MAP) kinase, and extracellular signal-regulated kinase (ERK) in osteoclast precursors in response to RANKL. Furthermore, silibinin attenuates the induction of nuclear factor of activated T cells (NFAT) c1 and osteoclast-associated receptor (OSCAR) expression during RANKL-induced osteoclastogenesis. We demonstrate that silibinin can inhibit TNF-α-induced osteoclastogenesis as well as the expression of NFATc1 and OSCAR. Taken together, our results indicate that silibinin has the potential to inhibit osteoclast formation by attenuating the downstream signaling cascades associated with RANKL and TNF-α.</P>
Kim, Junwon,Park, Hye-Young,Kim, Jaeseung,Ryu, Jiyoung,Kwon, Do Yoon,Grailhe, Regis,Song, Rita Royal Society of Chemistry 2008 Chemical communications Vol.2008 No.16
<P>Ni–nitrilotriacetic acid (NTA) functionalized CdSe/ZnS quantum dots (QDs) were exploited as a site-specific labeling agent of histidine-tagged biomolecules in live cells; the QDs were found to be water-soluble, aggregation free and stable for several months.</P> <P>Graphic Abstract</P><P>Ni–nitrilotriacetic acid (NTA) functionalized quantum dots (QDs) were exploited as a site-specific labeling agent of histidine-tagged proteins in live cells. The Ni–NTA modified QDs were found to be water-soluble, aggregation free and stable for several months. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b719434j'> </P>
Validation of CAN-CAN Gateway in the Automotive Network System
Junwon Kim,KeyHo Kwon,JaeWook Jeon 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
Currently, the increasing functions required for the automobile are making the automotive network more complicated. As this complexity grows, the increment of network bus load is one of the problems. To solve this issue, using a gateway is one solution. However, if one behavior in the gateway goes wrong, sending accurate information to the gateway or Electronic Control Unit (ECU) of another domain is impossible, and this will bring malfunctions to the automotive system. Currently there are no definite evaluation entries for gateway behavior, or evaluation standards for the stability and reliability of a network using the gateway. The purpose of this paper is to propose entries for validating CAN-CAN gateway behavior, and a validation method. Also, this paper validates the entries and the method by using an embedded system gateway.