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Fluorescence Probes for Tyrosine Dephosphorylation Based on Coumarin–Proline Conjugates
Choi, Kihang,Park, Bongjeong,Han, So-Yeong,Ahn, Hee Choon The Chemical Society of Japan 2011 Chemistry letters Vol.40 No.3
<P>Proline-substituted coumarin compounds were prepared and used as environment-sensitive fluorescence probes. Phosphorylation and dephosphorylation of tyrosine derivatives labeled with the coumarin–proline conjugate induced marked changes in fluorescence intensity allowing phosphatase activity to be monitored.</P>
장호종,KIHANG YOUN 한국산업응용수학회 2018 Journal of the Korean Society for Industrial and A Vol.22 No.3
We describe aparallel implementation of a relaxed Hermitian and skew-Hermitian splitting preconditioner for the numerical solution of saddle point problems arising from the steady incompressible Navier-Stokesequations. The equations are linearized by the Picarditeration and discretized with the finite element and finite difference schemes on two-dimensional and three-dimensional domains. We report strong scalability results for up to 32 cores.
Jung, Sun hwa,Choi, Kihang,Pae, Ae Nim,Lee, Jae Kyun,Choo, Hyunah,Keum, Gyochang,Cho, Yong Seo,Min, Sun-Joon The Royal Society of Chemistry 2014 Organic & Biomolecular Chemistry Vol.12 No.47
<P>This article describes the rapid and diversified synthesis of pyrrolidinyl triazoles for the discovery of mitochondrial permeability transition pore (mPTP) blockers. The 1,3-dipolar cycloaddition of ethynyl trifluoroborate with azidopyrrolidine produced a key intermediate, triazolyl trifluoroborate <B>4</B>, which subsequently underwent a Suzuki–Miyaura coupling reaction to afford a series of 1,4-disubstituted triazoles <B>2</B>. Subsequent biological evaluation of these derivatives indicated <B>2ag</B> and <B>2aj</B> as the most potent mPTP blockers exhibiting excellent cytochrome P450 (CYP) stability when compared to the previously reported oxime analogue <B>1</B>. The present work clearly demonstrates that a 1,2,3-triazole can be used as a stable oxime surrogate. Furthermore, it suggests that late-stage diversification through coupling reactions of organotrifluoroborates is suitable for the rapid discovery of biologically active molecules.</P> <P>Graphic Abstract</P><P>Pyrrolidinyl triazoles were synthesized <I>via</I> Huisgen 1,3-dipolar cycloadditions of ethynyl trifluoroborate followed by Suzuki–Miyaura coupling reactions and biologically evaluated as potential mPTP blockers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4ob01967a'> </P>
Park, Minjung,Kim, Seon-mi,Choi, Kihang The Royal Society of Chemistry 2012 Organic & Biomolecular Chemistry Vol.10 No.40
<P>New chiral derivatizing agents have been prepared through a simple, short-step synthesis. The absolute configuration of α-chiral carboxylic acids can be assigned on the basis of the NMR chemical shift difference between diastereomeric esters. Because of the modular structures of the agents, the anisotropic effect could be easily manipulated to afford large chemical shift differences even in polar solvents.</P> <P>Graphic Abstract</P><P>New derivatizing agents with simple and modular structures have been prepared from aminoindanol for the absolute configuration assignment of carboxylic acids. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2ob26168e'> </P>
Kaur, Matinder,Ahn, Ye-Hee,Choi, Kihang,Cho, Min Ju,Choi, Dong Hoon The Royal Society of Chemistry 2015 Organic & Biomolecular Chemistry Vol.13 No.26
<P>A bifunctional fluorescent probe based on a carbazole-pyrimidine conjugate for Hg2+ and Cu2+ detection was designed and synthesized. Probe 3 exhibits red shifts in its absorption and fluorescence spectra with significant visual color changes in the presence of these ions. The detection limits of probe 3 for these metal ions were in the nanomolar range. The probe could also be useful as a solid optical sensor for Hg2+ and Cu2+.</P>
Kim, Ji Young,Son, Myung-Hee,Choi, Kihang,Baek, Du-Jong,Ko, Min Kyung,Lim, Eun Jeong,Pae, Ae Nim,Keum, Gyochang,Lee, Jae Kyun,Cho, Yong Seo,Choo, Hyunah,Lee, Youn Woo,Moon, Byung Seok,Lee, Byung Cheol Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [$^{11}C$]MPEQ 3 proved that accumulation of [$^{11}C$]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.
Kaur, Matinder,Seul Yang, Da,Shin, Jicheol,Wan Lee, Tae,Choi, Kihang,Ju Cho, Min,Hoon Choi, Dong The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.48
<P>A new tellurophene-based π-conjugated polymer, PDTDPPTe, was synthesized. PDTDPPTe exhibits a smaller optical band gap (<I>E</I><SUB>g</SUB><SUP>opt</SUP> = 1.25 eV) than thiophene-based PDTDPPT (<I>E</I><SUB>g</SUB><SUP>opt</SUP> = 1.30 eV). Thin-film transistors comprising PDTDPPTe displayed outstanding performance (<I>μ</I><SUB>max</SUB> = 1.78 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, <I>I</I><SUB>on</SUB>/<I>I</I><SUB>off</SUB> = 10<SUP>5–6</SUP>).</P> <P>Graphic Abstract</P><P>We report the synthesis of a tellurophene- and DPP-based conjugated polymer using the Stille coupling reaction (88% yield). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc41250d'> </P>
Pillared Covalent Organic Frameworks with Balanced Volumetric and Gravimetric Hydrogen Uptake
Kim, Daejin,Jung, Dong Hyun,Kim, Kyung-Hyun,Guk, Hyein,Han, Sang Soo,Choi, Kihang,Choi, Seung-Hoon American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol. No.
<P>On the basis of our modeling of pillared covalent organic frameworks (PCOFs) with pyridine molecules inserted between the COF-1 layers, we propose that the surface area and free volume of storage materials should be balanced to increase the gravimetric and volumetric hydrogen uptake capacities. Density functional theory and grand canonical Monte Carlo simulations show that these PCOFs have significantly improved gravimetric and volumetric hydrogen storage capacities of 8.8–10.0 wt % and 58.7–61.7 g L<SUP>–1</SUP>, respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-1/jp2080622/production/images/medium/jp-2011-080622_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp2080622'>ACS Electronic Supporting Info</A></P>