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S-364 : Carotid plaque and progression of renal dysfunction in patients with chronic kidney disease
( Yong Seol Jeong ),( Young Rim Song ),( Sung Gyun Kim ),( Hyung Jik Kim ),( Jwa Kyung Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Carotid plaque is a surrogate marker of systemic atherosclerosis and closely associated with adverse cardiovascular outcomes. However, data regarding the predictive role of carotid plaque for renal progression are limited in chronic kidney disease (CKD) patients. Methods: This is a longitudinal observational study with a cohort of 411 Stage 3 and 4 CKD patients. A carotid plaque was defined as a focal structure encroaching into the arterial lumen of at least 0.5 mm or 50% of the surrounding carotid intima-media thickness (cIMT). Renal function decline was measured by estimated glomerular filtration (eGFR) slope and the renal endpoint was defined as the start of dialysis. Results: Baseline eGFR was 44.5±11.6 mL/min/1.73m2 and eGFR slope was -2.87±3.76 min/1.73m2/yr. A carotid plaque was found in 282 (68.6%) patients, and these patients had significantly faster rates of renal function decline than those without plaque (-3.64±3.84 vs. -1.20±2.85 mL/min/1.73m2/yr, p<0.001). According to multivariate analysis, statistically significant variables determining eGFR slope were diabetes (β=-0.77, p=0.033), increased pulse pressure (β=-0.02, p=0.015), elevated proteinuria (β=-0.50, p<0.001), increased cIMT (β=-4.36, p<0.001) and the presence of a carotid plaque (β=-1.48, p<0.001). Particularly, irregular plaque surface significantly associated with rapid decline of renal function. During the 2.5-year follow-up, 47 (11.4%) of patients started dialysis. Patients with carotid plaque had a poorer dialysis-free survival rate than those without carotid plaque (hazard ratio 3.3: 95% confidence interval 1.01, 10.77). Conclusions: Carotid plaque was closely associated with rapid decline of renal function and progression to dialysis in stage 3 and 4 CKD patients. survival.
Jeong Hannah,Kim Jwa-Young,Che Xiangguo,Choi Je-Yong,Jang Insan,Kim Seong-Gon 대한치과교정학회 2023 대한치과교정학회지 Vol.53 No.6
Objective: To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models. Methods: Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group). The remaining 20 healthy rats were divided into control and 4HR groups. We administered 4HR subcutaneously at a weekly dose of 10 mg/kg until the rats were euthanized. At 16 weeks of age, whole blood was collected, and micro-computed tomography of the skull and femur was performed. Results: All craniofacial linear measurements were smaller in the STZ group than in the control group. The mandibular molar width was significantly smaller in the 4HR group than in the control group (P = 0.031) but larger in the STZ/4HR group than in the STZ group (P = 0.011). Among the diabetic animals, the STZ/4HR group exhibited significantly greater cortical bone thickness, bone mineral density, and bone volume than the STZ group. Serum testosterone levels were also significantly higher in the STZ/4HR group than in the STZ group. Conclusions: 4HR administration may have divergent effects on mandibular growth and bone mass in healthy and diabetic rats. In the context of diabetes, 4HR appears to have beneficial effects, potentially through the modulation of mitochondrial respiration.
Jeong, Yu-on,Shin, Soo Jung,Park, Jun Yong,Ku, Bo Kyeong,Song, Ji Soo,Kim, Jwa-Jin,Jeon, Seong Gak,Lee, Sang Min,Moon, Minho MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.6
<P>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive deficits, neuroinflammation, and neuronal death. The primary pathogenic cause is believed to be the accumulation of pathogenic amyloid beta (Aβ) assemblies in the brain. Ghrelin, which is a peptide hormone predominantly secreted from the stomach, is an endogenous ligand for the growth hormone secretagogue-receptor type 1a (GHS-R1a). MK-0677 is a ghrelin agonist that potently stimulates the GHS-R1a ghrelin receptor. Interestingly, previous studies have shown that ghrelin improves cognitive impairments and attenuates neuronal death and neuroinflammation in several neurological disorders. However, it is unknown whether MK-0677 can affect Aβ accumulation or Aβ-mediated pathology in the brains of patients with AD. Therefore, we examined the effects of MK-0677 administration on AD-related pathology in 5XFAD mice, an Aβ-overexpressing transgenic mouse model of AD. MK-0677 was intraperitoneally administered to three-month-old 5XFAD mice. To visualize Aβ accumulation, neuroinflammation, and neurodegeneration, thioflavin-S staining and immunostaining with antibodies against Aβ (4G8), ionized calcium-binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), neuronal nuclear antigen (NeuN), and synaptophysin were conducted in the neocortex of 5XFAD and wild-type mice, and to evaluate changes of phosphorylated cyclic adenosine monophosphate (cAMP) response element binding protein (pCREB) levels, immunostaining with antibody against pCREB was performed in dentate gyrus of the hippocampus of 5XFAD and wild-type mice. The histological analyses indicated that MK-0677-treated 5XFAD mice showed reduced Aβ deposition, gliosis, and neuronal and synaptic loss in the deep cortical layers, and inhibited the decrement of pCREB levels in dentate gyrus of the hippocampus compared to vehicle-treated 5XFAD mice. Our results showed that activation of the ghrelin receptor with MK-0677 inhibited the Aβ burden, neuroinflammation, and neurodegeneration, which suggested that MK-0677 might have potential as a treatment of the early phase of AD.</P>
( Jwa Hoon Kim ),( Do Hoon Kim ),( Hee Young Yoon ),( Ji Wan Lee ),( Hyung Woo Cho ),( Soo Min Jeung ),( Eun Jeong Gong ),( Hwoon Yong Jung ),( Jin Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Tuberculosis rarely involves the esophagus, and the most esophageal tuberculosis occurs secondary to adjacent tuberculous lymphadenitis. Esophago-mediastinal fi stula is very rare complication of tuberculous lymphadenitis. A 28-year-old, previously healthy female visited the outside hospital due to nausea, vomiting, and fever. Chest CT(Computed tomography) showed enlargement of multiple, mediastinal lymph nodes with air density in the mediastinum, and thus suggesting an esophago-mediastinal fi stula. Esophagogram showed the extraluminal contrast leakage in cervical esophagus. Esophagogastroduodenoscopy(EGD) showed the deep ulcer with the fi stula opening at 24cm from the upper incisor teeth. Tuberculosis(Tb) polymerase chain reaction(PCR) on the sputum was positive. A biopsy of the right subclavian lymph node revealed necrotizing granuloma with Tb PCR positive. We diagnosed as tuberculous mediastinal lymphadenitis with esophago-mediastinal fi stula. The referring doctor failed to close the fi stula by endoscopic clipping. Therefore, we decided to use anti-Tb medications to treat fi stula via gastrostomy, because of severe nausea and vomiting. After four weeks, EGD and esophagogram showed that the fi stula opening was closed. The present case highlights the importance of anti-Tb medications in treatment of esophago-mediastinal fi stula due to tuberculous mediastinal lymphadenitis. n.
Gamma-irradiation of Streptococcus pneumoniae for the use as an immunogenic whole cell vaccine
Jwa, Min Yong,Jeong, Soyoung,Ko, Eun Byeol,Kim, A Reum,Kim, Hyun Young,Kim, Sun Kyung,Seo, Ho Seong,Yun, Cheol-Heui,Han, Seung Hyun MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.8
Jwa, Min Yong,Ko, Eun Byeol,Kim, Hyun Young,Kim, Sun Kyung,Jeong, Soyoung,Seo, Ho Seong,Yun, Cheol-Heui,Han, Seung Hyun Elsevier 2018 Microbial pathogenesis Vol.124 No.-
<P><B>Abstract</B></P> <P> <I>Streptococcus pneumoniae</I> is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and cost-effective vaccines. Recently, an intranasal vaccine formulated with gamma-irradiated nonencapsulated <I>S. pneumoniae</I> whole cells has been developed and its immunogenicity is under investigation. Since innate immunity influences the subsequent adaptive immunity, in the present study, we investigated the immunostimulatory activity of gamma-irradiated <I>S. pneumoniae</I> (r-SP) in the human bronchial epithelial cell-line, BEAS-2B, by comparing with heat-inactivated <I>S. pneumoniae</I> (h-SP) and formalin-inactivated <I>S. pneumoniae</I> (f-SP). r-SP potently induced interleukin (IL)-6 and IL-8 at both mRNA and protein levels in a dose- and time-dependent manner, whereas h-SP and f-SP poorly induced them. Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 × 10<SUP>7</SUP> CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 × 10<SUP>7</SUP> CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. The expression of IL-6 and IL-8 induced by r-SP was mediated through the activation of mitogen-activated protein kinases. Remarkably, when r-SP was further treated with heat or formalin, there was a decrease in the aforementioned activities. Taken together, we suggest that r-SP stimulates the human respiratory epithelial cells to produce the cytokines IL-6 and IL-8, which might influence the induction of adaptive immune responses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> r-SP induces IL-6 and IL-8 expression more potently than h-SP or f-SP in BEAS-2B cells. </LI> <LI> r-SP phosphorylates MAP kinases more potently than h-SP or f-SP in BEAS-2B cells. </LI> <LI> r-SP strongly activates TLR2 compared with h-SP or f-SP. </LI> <LI> Soluble components of r-SP are responsible for the potent immunostimulatory activity. </LI> </UL> </P>
Jeong, Namjo,Kim, Han-ki,Kim, Won-sik,Choi, Ji Yeon,Han, Ji-hyung,Nam, Joo-youn,Hwang, Kyo Sik,Yang, SeungCheol,Jwa, Eun-Jin,Kim, Tae-Young,Park, Soon-Chul,Seo, Yong-Seog,Kim, Sung-in Elsevier 2019 Chemical engineering journal Vol.356 No.-
<P><B>Abstract</B></P> <P>The direct integration of two-dimensional nanostructures into macroscopic porous carbon substrates is essential for their practical use in potential applications, which is a big challenge due to the difficulty of securing uniform coating layers. In this work, we demonstrate a very simple and effective method for the direct coating of MoS<SUB>2</SUB> onto the surface of porous carbon structures having nano-sized pores, such as vertically aligned carbon nanotube arrays. A uniform coverage of MoS<SUB>2</SUB> over carbon substrates was achieved by chemical vapor deposition of gaseous species derived from starting precursors in a closed reactor. Transmission electron microscopy images, X-ray diffraction data, and Raman spectra confirmed the formation of highly crystalline MoS<SUB>2</SUB> layers. X-ray photoelectron and energy dispersive X-ray spectroscopies revealed highly uniform MoS<SUB>2</SUB> layers over the whole surface of the carbon substrates. Our approach is also applicable for the synthesis of MoS<SUB>2</SUB>/carbon fiber paper (CFP) hybrid structures. The electrochemical tests showed that the as-synthesized MoS<SUB>2</SUB>/CFP structures can serve as highly active cathodes for reverse electrodialysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MoS<SUB>2</SUB>@VCNT and MoS<SUB>2</SUB>@CFP were prepared in this work. </LI> <LI> Uniform MoS<SUB>2</SUB> coating was achieved by CVD of gaseous species in the closed reactor. </LI> <LI> This approach is very powerful for MoS<SUB>2</SUB> coating over macroscopic porous substrates. </LI> <LI> MoS<SUB>2</SUB>/CFP can be a highly active cathode for reverse electrodialysis. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>