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Influence Maximization Based on Minimum Redundancy Feature Selection in Pocket Switched Networks
Kiyoung Jang,Junyeop Lee,YoungOk Kwon,Byung Cho Kim,Dongwon Lee,Wonseok Oh,Sung-Bong Yang 한국정보기술학회 2016 한국정보기술학회논문지 Vol.14 No.8
It is very crucial for viral marketing to determine a handful of influential users who can disseminate the product information to the users in a network. Influence maximization is a problem of finding k users to maximize the influence to all users in networks. In Pocket Switched Networks, all users do not have information about the entire network topology. Thus, it is essential to predict the future contact opportunities for forwarding messages by analyzing the node behaviors. In this paper, we propose an influence maximization scheme based on contact frequency of the users in the network. In the scheme, we obtain the contact frequency among the users in a regular time interval during the warm-up period. At the end of the warm-up period, the main server performs the feature selection process with the contact frequency. The minimum redundancy feature selection process yields the most important features, indicating the most influential users. Finally, the server selects promising users as the influential users with the feature selection. We show that the simulation results for the diffusion time performance of the proposed scheme. The proposed scheme shows 8.5% and 12.9% more improved performance than the random and set-cover scheme.
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park, Dae-Young,Lee, Junyeop,Park, Intae,Choi, Dongwon,Lee, Sunju,Song, Sukhyun,Hwang, Yoonha,Hong, Ki Yong,Nakaoka, Yoshikazu,Makinen, Taija,Kim, Pilhan,Alitalo, Kari,Hong, Young-Kwon,Koh, Gou Young American Society for Clinical Investigation 2014 The Journal of clinical investigation Vol.124 No.9
<P>Schlemm's canal (SC) is a specialized vascular structure in the eye that functions to drain aqueous humor from the intraocular chamber into systemic circulation. Dysfunction of SC has been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to elevated ocular pressure, a factor for glaucoma development in humans. Here, using lymphatic and blood vasculature reporter mice, we determined that SC, which originates from blood vessels during the postnatal period, acquires lymphatic identity through upregulation of prospero homeobox protein 1 (PROX1), the master regulator of lymphatic development. SC expressed lymphatic valve markers FOXC2 and integrin α9 and exhibited continuous vascular endothelial-cadherin (VE-cadherin) junctions and basement membrane, similar to collecting lymphatics. SC notably lacked luminal valves and expression of the lymphatic endothelial cell markers podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1). Using an ocular puncture model, we determined that reduced AHO altered the fate of SC both during development and under pathologic conditions; however, alteration of VEGF-C/VEGFR3 signaling did not modulate SC integrity and identity. Intriguingly, PROX1 expression levels linearly correlated with SC functionality. For example, PROX1 expression was reduced or undetectable under pathogenic conditions and in deteriorated SCs. Collectively, our data indicate that PROX1 is an accurate and reliable biosensor of SC integrity and identity.</P>
Chang, Yujung,Lee, Euiyeon,Kim, Junyeop,Kwon, Yoo-Wook,Kwon, Youngeun,Kim, Jongpil Elsevier 2019 Biomaterials Vol.192 No.-
<P><B>Abstract</B></P> <P>The reprogramming of induced cardiomyocytes (iCMs) has shown potential in regenerative medicine. However, <I>in vivo</I> reprogramming of iCMs is significantly inefficient, and novel gene delivery systems are required to more efficiently and safely induce <I>in vivo</I> reprogramming of iCMs for therapeutic applications in heart injury. In this study, we show that cationic gold nanoparticles (AuNPs) loaded with Gata4, Mef2c, and Tbx5 function as nanocarriers for cardiac reprogramming. The AuNP/GMT/PEI nanocomplexes show high reprogramming efficiency in human and mouse somatic cells with low cytotoxicity and direct conversion into iCMs without integrating factors into the genome. Importantly, AuNP/GMT/PEI nanocomplexes led to efficient <I>in vivo</I> conversion into cardiomyocytes after myocardial infarction (MI), resulting in the effective recovery of cardiac function and scar area. Taken together, these results show that the AuNP/GMT/PEI nanocarrier can be used to develop effective therapeutics for heart regeneration in cardiac disease patients.</P>
부영양화 사전 예방을 위한 휴대용 총인 모니터링 시스템 개발
정동건 ( Dong Geon Jung ),김승덕 ( Seung Deok Kim ),권순열 ( Soon Yeol Kwon ),이재용 ( Jae Yong Lee ),김유성 ( Yu Seong Kim ),이준엽 ( Junyeop Lee ),김재건 ( Jaekeon Kim ),김세완 ( Sae-wan Kim ),공성호 ( Seong Ho Kong ),정대웅 ( D 한국센서학회 2020 센서학회지 Vol.29 No.5
In this study, a portable total-phosphorus (TP) monitoring system utilizing a photocatalytic-reaction-based pretreatment method is proposed, fabricated, and characterized. Commercial TP monitoring systems are only used in laboratories because of their complex monitoring procedure, bulk-size, and high-cost. In particular, pretreatment in commercial TP monitoring systems is performed at high temperatures (> 120 ℃) and pressure (> 1.1 kg cm<sup>-2</sup>) making it difficult to minimize the scale of the systems. The proposed TP monitoring system employs a pretreatment method with a photocatalytic reaction; thus, its size can be reduced, as photocatalytic reactions occur at room temperature and atmospheric pressure. Analytes with various TP concentrations are pretreated using the proposed portable TP monitoring system and are quantitatively measured with an LED and a photodiode.