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Youn-Mook Lim,Hui-Jeong Gwon,Junwha Shin,Joon Pyo Jeun,Young Chang Nho 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.4
Macroporous poly(e-caprolactone) (PCL) scaffolds were prepared by gas foaming/salt leaching method. Their degradation behaviors were investigated as a function of radiation dose (total dose; 50, 100, 200, and 300 kGy: dose rate; 10 kGy/h) in vitro and in vivo. The PCL scaffolds have porosity of 86–96.8%. The porosity and mechanical strength could be controlled by the adjustment of an acid–base gas evolving reaction between citric acid and ammonium bicarbonate. The irradiated scaffolds were degraded faster than unirradiated ones. And scaffolds were degraded more slowly in vitro than in vivo regardless of irradiated or unirradiated ones.