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( Jun Hou ),( Xiangmo Zhao ),( Fei Hui ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
High peak-to-average power ratio (PAPR) of transmitted signals is a major drawback in Multicarrier modulation (MCM) systems. Companding transform is a well-known method to reduce the PAPR without restrictions on system parameters such as the number of subcarriers, frame format and constellation type. In this paper, a novel adaptive companding scheme, mainly focuses on compressing the large signals into the desirable distribution, is proposed to reduce the PAPR with low implementation complexity. In addition, formulas to calculate its PAPR and bit error rate (BER) performance are also derived. Simulation results confirm that the proposed scheme can achieve an effective tradeoff between PAPR reduction and BER performance by carefully choosing the companding parameter.
Fabrication of mesoporous silica-covered gold nanostars for chemophototherapy
Jun Hou,Yanbao Zhao,Lei Sun,Xueyan Zou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Gold nanomaterials have attracted great interest in the fight against cancer due to their surface features. In this study, gold nanostar (GNS) cloaked with mesoporous silica (GNS@mSiO2) carriers were preparedfor controlled drug release. The GNS core presents a branched morphology with tip-to-tip diameter of80–120 nm and core of 40–60 nm. In this system, GNS not only served as photothermal agent but alsoas Raman signal enhancement matrix. After encapsulating doxorubicin (DOX) within the GNS@mSiO2carrier, hyaluronic acid (HA) was coated on the GNS@mSiO2 surface to seal the loaded-drug of channels. The obtained DOX-GNS@mSiO2/HA displayed pH/enzyme-triggered drug release and photothermalchemotherapeutic effect.
Wang Xianyao,Wang Huizhen,Lu Junhou,Feng Zhanhui,Liu Zhongshan,Song Hailiang,Wang Heng,Zhou Yanhua,Xu Jianwei 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5
BACKGROUND: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited. METHODS: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Cell Counting Kit-8 was used to detect the viability of BM-MSCs after overexpressing EPO. Cell migration and apoptosis were verified using Boyden chamber and flow cytometry, respectively. Finally, the anti-fibrosis efficacy of EPO-MSCs was evaluated in vivo using immunohistochemical analysis. RESULTS: EPO overexpression promoted cell viability and migration of BM-MSCs without inducing apoptosis, and EPO-MSC treatment significantly alleviated liver fibrosis in a carbon tetrachloride (CCl4) induced mouse liver fibrosis model. CONCLUSION: EPO-MSCs enhance anti-fibrotic efficacy, with higher cell viability and stronger migration ability compared with treatment with BM-MSCs only. These findings support improving the efficiency of MSCs transplantation as a potential therapeutic strategy for liver fibrosis.