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Jung, Yuna,Kim, Youngseo,Kim, Na Hee,Lee, Junho,Kim, Kang-Hoon,Jung, Junyang,Huh, Youngbuhm,Jang, Hyeung-Jin,Joo, Jinmyoung,Park, Sungnam,Kim, Dokyoung Elsevier 2019 Dyes and pigments Vol.162 No.-
<P><B>Abstract</B></P> <P>A new wavelength-tunable and facilely functionable electron donor (D)-acceptor (A) type fluorescent naphthalene core skeleton and its application for cell membrane imaging are reported. The core skeleton shows bright green fluorescence with aldehyde(CHO) moiety at the electron acceptor site, and its emission wavelength is tuned to blue and red by introducing the moiety of nitrile (CN) and dicyanovinyl (CH(CN)<SUB>2</SUB>), respectively, at the acceptor site. In addition, the core skeleton can be readily functionable by introducing a targeting moiety at the extra hydroxyl group. For the first demonstration as a fluorescent probe, a long-chain carbon is introduced and evaluated its bio-imaging ability for the cellular membranes on cells and tissues by using confocal laser scanning microscopy (CLSM) and two-photon microscopy (TPM). The synthesis, photophysical property, and quantum chemical calculations are also identified.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A wavelength-tunable and facilely functionable D-A type naphthalene core skeleton was developed. </LI> <LI> The derivative shows bright fluorescence at blue, green, and red region, and its bio-imaging ability was verified in the cells and tissues. </LI> <LI> The developed core skeleton can be utilized as fluorescent probes with introducing of targeting moieties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We describe here a fluorescent core skeleton, which is wavelength-tunable, facilely functionable, and one-/two-photon microscopy applicable.</P> <P>[DISPLAY OMISSION]</P>
Clinical outcomes of omaliumab treatment on cholinergic urticaria
( Junho Kim ),( Donghyun Kim ),( Young Joo Kim ),( Da Woon Sim ),( Hye Jung Park ),( Kyung Hee Park ),( Jung-won Park ),( Jae-hyun Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Cholinergic urticaria is one of the inducible urticaria and it’s symptoms are provocated by a rise in body temperature. There are some conflicting case reports of omalizumab effect on cholinergic urticaria. Objective: The aim of this study was to evaluate the clinical effect of omalizumab on refractory cholinergic urticaria. Methods: We performed a single center, retrospective study. Since January 2014 to July 2015, 13 patients were treated with omalizumab after failure of antihistamine. Telephone survey including visual analog scale (VAS) and urticaria control test (UCT, 0-16, high score means better control) is performed and response is defined as complete (post treatment VAS≤2 & UCT≥12), partial and no response (post treatment VAS≤2 & UCT≥12). Results: 12 men and 1 women, with a mean age and disease duration of 28 years and 53 months, were included. All patients had at least 5 aggravating factors and 4 patients had chronic spontaneous urticaria and 6 patients had house dust mite sensitization on MAST. After omalizumab, VAS decreased from 8.23±0.93 to 3.69±2.56 (p<0.0001) and UCT increased from 3.77±1.42 to 9.77±3.66 (p> 0.0001) and 5 patients had complete response, while 5 and 3 patients had partial and no response. In responders, the number of injection, injection interval and serum eosinophil count were statistically significant higher than no responders. Conclusions: Our result shows that omalizumab might be useful in refractory cholinergic urticaria. Clinician should consider omalizumab in patients with antihistamine failure.
Jung, Junho,Lim, Hae Soo,Lee, Deok-Won Korean Academy of Dental Science 2018 Journal of korean dental science Vol.11 No.2
Purpose: Polydeoxyribonucleotide (PDRN), consisting of a mixture of deoxyribonucleotide polymers, has been suggested to have anti-inflammatory effects and enhance angiogenesis as an adenosine $A_{2A}$ receptor agonist. The aim of this study was to report the effectiveness of PDRN as an adjuvant therapy after surgical debridement in MRONJ (medication-related osteonecrosis of the jaw) patients. Materials and Methods: Five patients (1 male, 4 females, age 65~79 years) who were diagnosed with MRONJ stage 2 or 3 underwent surgical debridement and PDRN mucosal injection. After surgical debridement, patients were subject to daily injection with 1 ml of PDRN around the surgical wound for 14 days. Result: The patients' symptoms gradually disappeared. The surgical wound uneventfully healed, and no recurrence was observed during the follow-up period. Conclusion: Although further studies are required, the present study first describes the possibility of PDRN as a useful option for MRONJ treatment.
Floating septum technique: easy and safe method maxillary sinus septa in sinus lifting procedure
Jung, Junho,Hwang, Bo-Yeon,Kim, Byung-Soo,Lee, Jung-Woo Korean Association of Maxillofacial Plastic and Re 2019 Maxillofacial Plastic Reconstructive Surgery Vol.41 No.-
Background: The presence of septa increases the risk of Schneiderian membrane perforation during sinus lift procedure, and therefore, the chance of graft failure increases. We present a safe method of managing septa and, in particular, overcoming small and palatally located septa. Methods: After the elevation of the flap and the creation of a small bony window positioned anterior to the septum, the Schneiderian membrane is lifted carefully. A thin and narrow osteotome is then placed at the indentation created at the base of the septum, and mobilization of the septum is achieved by gentle malleting. The membrane is again carefully lifted up behind the septum. Results: There was one small membrane perforation case in all 16 cases, and none of these patients showed postoperative complications such as implant failure, infection, or maxillary sinusitis. Conclusions: This technique is useful for overcoming the problem of maxillary sinus septa hindering the sinus floor elevation procedure, leading to fewer complications.
( Junho Jung ),( Ilyoung Shin ),( Younghee Choi ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2023 Brain Tumor Research and Treatment Vol.11 No.3
Nontuberculous mycobacteria (NTM) is a type of bacteria that typically infects the pulmonary system, and NTM-central nervous system (CNS) infection, which occurs in the brain, is a very rare disease. A 64-year-old female patient presented with seizures as the main symptom and was found to have a mass of less than 1 cm in the right temporal lobe with accompanying edema. Although diseases such as tumor metastasis and parasitic cyst were suspected, the patient underwent a surgical resection, and NTM-CNS infection with abscess was diagnosed through biopsy. Antibiotic treatment was initiated after surgery, and the patient has been followed up without any significant symptoms. In this report, we review a rare case of NTM-CNS infection and discuss the understanding and treatment of this disease.
Jung, Junho,Moon, Seung-Hwan,Kwon, Yong-Dae Korean Association of Maxillofacial Plastic and Re 2020 Maxillofacial Plastic Reconstructive Surgery Vol.42 No.-
Considering psychosocial needs of patients, it is not surprising that surgery-first approach (SFA) is becoming more popular than ever. Although the concept of SFA was introduced a few decades ago, the limitation of analysis method based on two-dimensional images makes surgeons reluctant to choose SFA. Recently, the advancement of three-dimensional technology allows us to perform SFA even without minimal pre-surgical orthodontic treatment, and the prediction of surgical outcome became more accurate, especially in obstructive sleep apnea (OSA) patients to whom the advantages of SFA should be more significant. Here, we describe the current trend of SFA and its implication in OSA patients.
NoSQL based Web Service System for Sharing of Emotion Information in Cloud Computing
Junho Jung,Jeong Byun,DongKeun Kim3 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.3
We present the No-SQL based Web service system for sharing of emotion information regarding the individual emotional states and location information of users using by a MongoDB in cloud computing environments. Pre-processed emotion information represents the individual emotional states categorized as a nine domain based on physiological signals recognition within the database system. However, in order to present individual emotional states regarding to pre-processed user’s emotional states and locations on a Web-based map, the computational overload with large amount of data for a location-query process is to be solved for support sharing Web services. Meanwhile, previous RDBMS-based systems are inadequate due to insufficient scalability and processing time of data processing nodes. Therefore, in this paper, we have designed and implemented an emotion sharing web service by reducing the load on the system using NoSQL database. In addition, it was confirmed that it is possible to effectively utilize resources and visualized by using Google’s FusionTable and it is possible to share on a Web map.