Diffuse decidual leucocytoclastic necrosis and NK cell aggregates: two distinct features of miscarriage

Lee, Joong Yeup,Kim, Eun Na,Hong, Joon-Seok,Shim, Jae-Yoon,Hwang, Doyeong,Kim, Ki Chul,Lee, JungBok,Kim, Chong Jai British Medical Association 2015 Journal of clinical pathology Vol.68 No.2

<P><B>Aims</B></P><P>Primary histopathology of miscarriage remains undetermined in the majority of cases. This study was conducted to determine histological characteristics pertinent to miscarriage.</P><P><B>Methods</B></P><P>The study groups were composed of elective abortions (n=29) and miscarriages (n=45) comprised of chromosomally normal (n=15) and abnormal cases (n=30). Immunohistochemistry was done against CD3, CD8, TIA-1 and CD56.</P><P><B>Results</B></P><P>Two histological features—diffuse decidual leucocytoclastic necrosis (DDLN) and decidual natural killer cell aggregates (NKCA)—were relatively common in miscarriages. The frequencies of DDLN and NKCA were different between the groups (p<0.05 and p<0.05, respectively). DDLN was found in 13.8% (4/29) of elective abortions, while it was observed in 60.0% (9/15) and 23.3% (7/30) of chromosomally normal and abnormal miscarriages, respectively. DDLN was more frequent in chromosomally normal miscarriages than in elective abortions (p=0.004). NKCA was present in 13.8% (4/29) of elective abortions, while being found in 33.3% (5/15) and 43.3% (13/30) of chromosomally normal and abnormal miscarriages, respectively. NKCA was more frequent in chromosomally abnormal miscarriages than in elective abortions (p=0.020).</P><P><B>Conclusions</B></P><P>The findings strongly suggest that defective placentation and abnormal maternal immune response are associated with miscarriage. DDLN and NKCA seem to have diagnostic values in the pathological evaluation of miscarriage.</P>

Influence of image quality on curved liquid crystal display for immersive environment as viewing position

Lee, Jungbok,Kwak, Min-Gi,Lee, Chan-Jae Informa UK (TaylorFrancis) 2018 Molecular Crystals and Liquid Crystals Vol.663 No.1

Development of Simultaneous Separation Method for Alpha Radionuclides

Homyung Lee,Jong Ki Choi,JungBok Lee,Hajin Song,Chan Young Kim,Yong Jin Lee,Jungsuk Oh 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.11

Increase in serum haptoglobin and apolipoprotein M in patients with obstructive sleep apnoea

KIM, JINKWAN,LEE, SEUNGGWAN,IN, KWANGHO,KIM, JEHYEONG,YOU, SEHWA,KANG, KYUNGHO,SIM, JAEJEONG,LEE, SANGYEUB,YOON, DAEWUI,LEE, JUNGBOK,SHIN, CHOL Blackwell Publishing Ltd 2009 Journal of sleep research Vol.18 No.3

<P>Summary</P><P>Obstructive sleep apnoea (OSA) is a common syndrome, which is associated with a number of medical problems that impact morbidity and mortality. Although the precise mechanisms that underlie these associations are not fully understood, previous studies have suggested that patients with OSA show elevations of several biomarkers that are associated with cardiovascular risk. This study was undertaken to identify serum proteins associated with OSA by using a proteomics technique and to examine changes in identified protein levels after continuous positive airway pressure treatment. The study participants consisted of 40 male patients (aged 40–49 years) with severe OSA and 34 male control subjects matched for age and body mass index. All subjects underwent polysomnography. Using a proteomics approach, we identified nine proteins that were differentially expressed in patients with severe OSA and controls. Three of these nine proteins, haptoglobin, paraoxonase-1 and apolipoprotein M, were quantified by using enzyme-linked immunosorbent assays, kinetic assays and by using Western blotting. Multiple regression analysis showed that haptoglobin and apolipoprotein M levels are independently related to apnoea–hypopnoea index (<I>P</I> < 0.01). A further study is required to determine the nature of associations between these identified proteins and OSA in a large population.</P>

유창성 장애의 언어치료 관련 경시적 계수자료의 유연한 분석

이수복(Soobok Lee),이정복(Jungbok Lee) 한국자료분석학회 2023 Journal of the Korean Data Analysis Society Vol.25 No.6

In this study, the goal was to apply a flexible and easy-to-manage analysis method through a model that includes a dispersion parameter in the longitudinal analysis method of count data. In the analysis of count data, it may be inconvenient to change the statistical model depending on whether there is under- or over-dispersion. To compensate for these weaknesses, We have applied a statistical method including a dispersion parameter to the statistical model. The count data covered were included in the diagnosis of fluency disorders and the evaluation of the effectiveness of speech therapy. but research on speech-language therapy is limited by being conducted on small numbers of subjects for several reasons. Therefore, statistical analysis methods that work only on large samples, are complex, or require excessive calculations in the model fitting process were not appropriate for the field. With this background, we applied the Conway-Maxwell Poisson model to longitudinal data analysis of fluency disorders. We evaluated whether the model that reflects the level of data dispersion in the model was consistent with the speech therapy data for fluency disorders by comparing it to the existing Poisson mixed model and linear mixed model. In particular, the Conway-Maxwell Poisson model had the advantage of reflecting well when the degree of dispersion was different for each group or specific subgroup. 본 연구에서는 계수자료의 경시적 분석 방법에서 산포 모수를 포함하는 모형을 통해 유연하고, 용이한 분석 방법을 논의하는 것을 목표로 하였다. 계수자료의 분석에서는 과소, 과대 산포여부에 따라 통계적 모형을 변경해야 하는 번거로움이 있을 수 있다. 이러한 약점을 보완하는 하나의 방법으로 통계적 모형에 산포 모수를 포함한 통계적 방법을 적용하기로 하였다. 본 연구에서 다루는 유창성 장애의 진단, 언어치료의 효과 평가에서는 다양한 계수자료가 포함되어 있으나, 언어치료 연구는 여러 이유로 인하여 소수의 대상자에서 수행되는 제약을 갖고 있다. 그러므로 대표본에서나 작동하거나 복잡하거나 모형 적합 과정에 과도한 계산 요구는 통계적 분석방법은 해당 분야에 적합하지 않았다. 이러한 배경하에 본 연구에서는 Conway-Maxwell 포아송 모형을 경시적 자료 분석에 적용하였으며, 자료의 산포 수준을 모형안에 반영하는 모형이 기존의 포아송 혼합모형, 선형혼합모형에 비교하여 유창성 장애의 언어치료 자료에 부합하는지 평가하였다. 특히 Conway-Maxwell 포아송 모형에서 각 군별 또는 특정 소집단별로 산포의 정도가 다를 경우 이를 잘 반영하는 장점이 있었다.

Efficiency Calibration of C-14 for LSC – It’s Problems and Resolutions

Hajin Song,JungBok Lee,Jong Ki Choi,Chan Young Kim,Homyung Lee,Yong Jin Lee,Jungsuk Oh 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.11

Micro via and line patterning for PCB using imprint technique

Seunghyun Ra,Choonkeun Lee,Jaechoon Cho,Sangmoon Lee,Jungwoo Lee,Myungho Hong,Jungbok Kwak 한국물리학회 2008 Current Applied Physics Vol.8 No.6

Today’s electronic devices such as mobile phones, PDA, computers, etc. have more functions in a smaller size. Thus conducting lines and via holes of PCB (printed circuit board) which has a role of land for all kinds of electronic components are getting finer. In this study, the conducting lines and via holes are produced using thermal imprint technique rather than the conventional photo-lithography process. Imprint technique is a press process that transfers patterns of stamp to resins. Imprint technique is used to produce micro size trench lines and via holes in epoxy resins. Resins used in this work are silica (SiO₂) reinforced epoxy. Resins were imprinted using 10 * 10 mm size Ni or polymer stamp. Line/ space of pattern is 10/10 lm while diameter of via hole is 30 lm. The depths of lines and via holes are 15 and 30 lm, respectively. The anti-sticking treated stamp and epoxy resins were pressed at 100℃ for 30 min in vacuum. The stamp was released after resins were cured for 1 h at 130℃. All patterns of stamp were successfully transferred with high fidelity and any noticeable defect was not observed within imprinted area. Imprinted resins were de-smeared to remove the residue at the bottom of via holes and to enhance the adhesion of resins with Cu. Electro/less copper plating was followed to fill in the imprinted patterns. Since the excess Cu layer was formed on the resins during Cu plating, the planarization process was introduced to obtain isolated lines and via holes. Today’s electronic devices such as mobile phones, PDA, computers, etc. have more functions in a smaller size. Thus conducting lines and via holes of PCB (printed circuit board) which has a role of land for all kinds of electronic components are getting finer. In this study, the conducting lines and via holes are produced using thermal imprint technique rather than the conventional photo-lithography process. Imprint technique is a press process that transfers patterns of stamp to resins. Imprint technique is used to produce micro size trench lines and via holes in epoxy resins. Resins used in this work are silica (SiO₂) reinforced epoxy. Resins were imprinted using 10 * 10 mm size Ni or polymer stamp. Line/ space of pattern is 10/10 lm while diameter of via hole is 30 lm. The depths of lines and via holes are 15 and 30 lm, respectively. The anti-sticking treated stamp and epoxy resins were pressed at 100℃ for 30 min in vacuum. The stamp was released after resins were cured for 1 h at 130℃. All patterns of stamp were successfully transferred with high fidelity and any noticeable defect was not observed within imprinted area. Imprinted resins were de-smeared to remove the residue at the bottom of via holes and to enhance the adhesion of resins with Cu. Electro/less copper plating was followed to fill in the imprinted patterns. Since the excess Cu layer was formed on the resins during Cu plating, the planarization process was introduced to obtain isolated lines and via holes.

Diagnostic Trends and Clinical Characteristics of Eosinophilic Esophagitis: A Korean, Single-center Database Study

Ga Hee Kim,정기욱,Hwoon-Yong Jung,Kee Don Choi,JungBok Lee,Young Soo Park,So-Woon Kim,Jeong Hoon Lee,Do Hoon Kim,Ji Yong Ahn,Ho June Song,Gin Hyug Lee,Jin-Ho Kim 대한소화기 기능성질환∙운동학회 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.2

Background/Aims The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods Using an endoscopic database maintained at a tertiary care center, we retrospectively reviewed the biopsy reports regarding 18 399 biopsy specimens collected from all patients who underwent esophagogastroduodenoscopy and esophageal biopsy at this facility between 2006 and 2014. The presence of more than 15 eosinophils per high-power field with symptoms related to esophageal dysfunction was considered to indicate EoE. Results A total of 37 patients (male:female ratio, 29:8; mean age, 44.0 ± 13.0 years) were diagnosed with EoE. These patients presented with dysphagia (21.6%), epigastric pain (21.6%), heartburn (24.3%), and other symptoms (32.4%). Typical endoscopic appearance of EoE was noted in 33 cases (89.1%) and included linear furrows in 24 cases (64.8%), ringed esophagus in 10 cases (27.0%), and white exudates in 11 cases (29.7%). The median eosinophilic count was 25 per high-power field (interquartile range, 20–70). Notable histopathological findings included eosinophilic microabscesses in 21 cases (56.7%). The diagnosis rate of EoE was found to have increased from 2006 and to 2014 (P-value < 0.001 by the Cochran-Armitage trend test). Conclusions The number of patients with EoE appears to have increased significantly over the 9-year period investigated, while the number of endoscopic investigations increased only marginally. Greater awareness of EoE and the role of esophageal biopsies should be considered.

다변량 관측치를 갖는 임상시험에서 집단축차검정후 조건부 추정

이재원,이정복 高麗大學校統計硏究所 2002 應用統計 Vol.17 No.-

본 연구에서는 다변량 관측자료를 갖는 임상시험에서 집단축차검정후 점추정 및 구간추정 방법에 대해서 조건부 추정방법을 제안하여 추정량의 편의 감소 효과와 포함확률을 확인하였다. 점추정에서 Fan(2000a)이 제안 단일 관측치의 조건부 추정법을 다변량 관측치에서의 조건부 추정법으로 확장하였으며, 다변량 관측치의 조건부 정확신뢰구간을 제안하였다. 제안된 추정법의 효과를 확인하기 위해 모의실험을 통해 비조건부 최대우도추정량, 비조건부 중위불편추정량(median unbiased estimator) 100(1-alpha)% 정확 신뢰구간의 중간점(midpoint of exact confidence interval) 그리고 조건부 추정량(conditional estimator) 을 비교하였으며, 구간추정에 있어서는 쉽게 계산할 수 있는 방법(naive method)과 비조건부 정확 신뢰구간과 조건부 정확신뢰구간을 비교하였다. 조건부 추정방법에 대해 추정치의 편의를 줄여주는 효과를 확인하였으며, 구간추정에서도 기존 방법보다 향상된 결과를 얻었다. We compare bstopping of clinical with multivariate observations. For the point estimation, we investigate the properties of the maximum lidelihood estimator, median unbiased estimator, the midpoint of the exact confidence interval, the extended conditional estimator. For the interval estimation, the naive confidence interval, the repeated confidence interval, the unconditional exact confidence interval and the conditional exact confidence interval are considered under various situations.

국어 경어법의 전략적 용법에 대하여

이정복 서울대학교 어학연구소 1999 語學硏究 Vol.35 No.1

This paper aims to introduce and analyze the concept of strategic usage and its subclasses by distinguishing normative from strategic usage of Korean honorifics. Normative usage is defined as the speaker expresses and accepts personal relations - such as power or distance relations with the hearer - by the use of honorifics. Most Korean speakers know how to effectively use honorifics appropriate for various situations, based on age, gender, generation, personal intimacy, and so on. This common intuition among the speakers passes for a quasi-constrained norm of the speech community. So it is more basic and usual usage of Korean honorifics. However, in a sense, strategic usage is defined as a means by which the speaker uses language minipulatively to achieve a special purpose through the change of honorific usage. Therefore, strategic usage, unlike normative usage, involves particular purposes, and stronger intentions on the part of the speaker. Also the change in honorific usage is essential to this strategy. It is obviously distinguished from basic or normative usage in that the speaker intensionally adjusts the degree of treatment for the hearer by changing both speech levels and title. It has five subclasses: the strategy of "highly treating the giver," "rearranging the conflictive social facts," "showing off the speaker's higher status," "changing the speaker's identity," and "adjusting psychological distance with the hearer." Strategic usage of Korean honorifics plays a major role in the use of Korean language. It adjusts and maintains social relations and the psychological distance among participants. It is an efficient means to understand Korean people and their mutual relations in society. From this perspective, I focused my research on the strategic usage of honorifics which has been ignored for a long time. Thus, I think we could view Korean honorifics with less prejudice and further widen our understanding of the language and social life of the Korean people.