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Jung Sub Lee(이정섭),Chang Won Kim(김창원),Kuen Tak Suh(서근택) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
요추 동맥 손상에 대한 여러 보고가 있으나 둔상이나 관통상에 의한 요추 동맥 손상으로 발생한 혈류 감소성 쇼크에 대한 보고는 드물다. 이에 저자들은 3m 높이에서 낙상하여 2번째 요추 동맥 손상으로 후복막 출혈을 보인 47세 남자 환자를 보고하고자 한다. There are many reports on lumbar artery injuries. However, there are only a few case reports of a lumbar artery injury presenting with hypovolemic shock from either a blunt or penetrating trauma. We described a 47-year-old man with a retroperitoneal hemorrhage secondary to a lumbar artery injury presenting as hypovolemic shock after a 3 m fall.
Jung, Young-Ok,Kim, Inje,Kim, Suho,Suh, Chang-Hee,Park, Han Jung,Park, Won,Kwon, Seoung Ryul,Jeong, Jae Cheon,Lee, Yun Jong,Ryu, Hee Jung,Park, Young Bae,Lee, Jisoo,Lee, You-Hyun,Seo, Young Il,Chung, The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.4
<P>The objective of this study was to investigate clinical and radiographic features and gender differences in Korean patients with adult-onset ankylosing spondylitis. Multicenter cross-sectional studies were conducted in the rheumatology clinics of 13 Korean tertiary referral hospitals. All patients had a confirmed diagnosis of ankylosing spondylitis according to the modified New York criteria. Clinical, laboratory, and radiographic features were evaluated and disease activities were assessed using the Bath ankylosing spondylitis disease activity index. Five hundred and five patients were recruited. The male to female ratio was 6.1:1. Average age at symptom onset was 25.4±8.9 yr and average disease duration was 9.6±6.8 yr. Males manifested symptoms at a significantly earlier age. HLA-B27 was more frequently positive in males. Hips were more commonly affected in males, and knees in females. When spinal mobility was measured using tragus-to-wall distance and the modified Schober's test, females had significantly better results. Radiographic spinal changes, including bamboo spine and syndesmophytes, were more common in males after adjustment of confounding factors. In conclusion, we observed significant gender differences in radiographic spinal involvement as well as other clinical manifestations among Korea patients with adult-onset ankylosing spondylitis. These findings may influence the timing of the diagnosis and the choice of treatment.</P>
Suh Yun Seok,Choi Jae Won,Yoon Jeong Hee,Lee Dong Ho,Kim Yoon Jun,Lee Jeong-Hoon,Yu Su Jong,Cho Eun Ju,Yoon Jung-Hwan,Lee Jeong Min 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.12
Objective: This study aimed to compare the efficacy between no-touch (NT) radiofrequency ablation (RFA) and conventional RFA using twin internally cooled wet (TICW) electrodes in the bipolar mode for the treatment of small hepatocellular carcinomas (HCC). Materials and Methods: In this single-center, two-arm, parallel-group, prospective randomized controlled study, we performed a 1:1 random allocation of eligible patients with HCCs to receive NT-RFA or conventional RFA between October 2016 and September 2018. The primary endpoint was the cumulative local tumor progression (LTP) rate after RFA. Secondary endpoints included technical conversion rates of NT-RFA, intrahepatic distance recurrence, extrahepatic metastasis, technical parameters, technical efficacy, and rates of complications. Cumulative LTP rates were analyzed using Kaplan-Meier analysis and the Cox proportional hazard regression model. Considering conversion cases from NT-RFA to conventional RFA, intentionto- treat and as-treated analyses were performed. Results: Enrolled patients were randomly assigned to the NT-RFA group (37 patients with 38 HCCs) or the conventional RFA group (36 patients with 38 HCCs). Among the NT-RFA group patients, conversion to conventional RFA occurred in four patients (10.8%, 4/37). According to intention-to-treat analysis, both 1- and 3-year cumulative LTP rates were 5.6%, in the NT-RFA group, and they were 11.8% and 21.3%, respectively, in the conventional RFA group (p = 0.073, log-rank). In the as-treated analysis, LTP rates at 1 year and 3 years were 0% and 0%, respectively, in the NT-RFA group sand 15.6% and 24.5%, respectively, in the conventional RFA group (p = 0.004, log-rank). In as-treated analysis using multivariable Cox regression analysis, RFA type was the only significant predictive factor for LTP (hazard ratio = 0.061 with conventional RFA as the reference, 95% confidence interval = 0.000–0.497; p = 0.004). There were no significant differences in the procedure characteristics between the two groups. No procedure-related deaths or major complications were observed. Conclusion: NT-RFA using TICW electrodes in bipolar mode demonstrated significantly lower cumulative LTP rates than conventional RFA for small HCCs, which warrants a larger study for further confirmation.
A New Pea Cultivar, Cheongmi with Short Stem Height, Lodging Resistance and High Yield
Won Young Han,Sang Ouk Shin,Myoung Gun Choung,Chan Sik Jung,Doo Chull Shin,Sea Kwan Oh,Sung Taeg Kang,In Youl Baek,Duck Yong Suh,Soon Chul Kim,Dong Kwan Kim,Chang Ki Son 한국육종학회 2004 한국육종학회지 Vol.36 No.5
A new pea cultivar, Cheongmi was developed at the Yeongnam Agricultural Research Institute (YARI) in 2003. It was selected from a cross YP303 (Frescoloy / Upton) // YP113 (Sparkle/Early Bird) /3/ YP115 (Sparkle / Euiseongjaerae) in 1992. The preliminary,
( Won-ju Kima ),( Ja-hyun Koo ),( Hyun-jung Cho ),( Jae-ung Lee ),( Ji Yun Kim ),( Sohee Lee ),( Jong Hoon Kim ),( Mi Seon Ohe Minah Suh ),( Eui-cheol Shin ),( Joo Yeon Ko ),( Myung Hyun Sohn ),최제민 ( 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
Background: Atopic dermatitis and psoriasis are the most common chronic inflammatory skin diseases. However, there are high unmet medical needs with limitations for transcutaneous drug development due to the skin barrier. Objective: We aimed to identify a novel transdermal delivery peptide and develop a transcutaneously applicable immune modulatory protein by targeting cytokine signaling in atopic dermatitis and psoriasis. Methods: We generated reporter proteins conjugated with a human-originated transdermal delivery peptide, AP and analyzed intracellular delivery efficiency in mouse or human skin cells and tissues. Especially, we utilized multi-photon confocal microscopy for visualizing the localized proteins. We also generated a recombinant therapeutic protein, AP-rPTP, which is conjugated with AP and phosphatase domain of TC-PTP targeting multiple STATs. Immune modulatory function of AP-rPTP was confirmed in splenocytes upon cytokine stimulation and TcR stimulation. Finally, we confirmed in vivo efficacy of AP-rPTP in OXA-induced acute dermatitis, OVA-induced chronic dermatitis, and imiquimod-induced psoriasis models. Results: AP-conjugated reporter proteins exhibited significant intracellular transduction efficacy in keratinocytes, fibroblasts, and immune cells. In addition, transcutaneous administration of AP-dTomato showed significant localization into the dermis and epidermis in mouse skin. AP-rPTP could inhibit pSTAT1, pSTAT3, and pSTAT6 in splenocytes and also regulate T cell activation and proliferation. Transcutaneous paper-patch of AP-rPTP protein significantly ameliorated ear thickness, tissue inflammation, and cytokine expression in allergy- as well as psoriasis-like dermatitis models. Conclusion: We identified a 9 amino acid-long novel transdermal delivery peptide and suggest the feasibility of utilizing AP for transcutaneous biologic drug development such as AP-rPTP as a novel immune modulatory drug candidate for dermatitis.