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Kim, Bong Jik,Han, Jae Joon,Shin, Seung Han,Kim, Han-Suk,Yang, Hye Ran,Choi, Eun Hwa,Chang, Mun Young,Lee, Sang-Yeon,Suh, Myung-Whan,Koo, Ja-Won,Lee, Jun Ho,Choi, Byung Yoon,Oh, Seung-Ha Hindawi 2018 BioMed research international Vol.2018 No.-
<P>Congenital cytomegalovirus (cCMV) infection is a common congenital infection that causes sensorineural hearing loss (SNHL). Despite its substantial impact on public health and cost burden, epidemiology and clinical features of CMV-related SNHL have never been reported in the Korean populations. This study investigated the detailed audiologic phenotypes of cCMV infection to see if a specific SNHL pattern is associated with a particular clinical setting. A total of 38 patients with cCMV infection were studied retrospectively. Patients were classified into three groups with distinct demographics: clinically driven diagnosis (n=17), routine newborn CMV screening according to the NICU protocols (n=10), or referral to ENT for cochlear implant (CI) (n=11). The incidence of cCMV infection was 3.6%, showing 33.3% of SNHL among cCMV patients, 38% of asymmetric hearing loss, 29% of late-onset hearing loss, and diverse severity spectrum in patients with CMV-related SNHL. CI recipients with CMV-related SNHL showed a significantly improved speech perception. Surprisingly, in 36.4 % of CI implantees, initial audiological manifestation was significant asymmetry of hearing thresholds between both ears, with better ear retaining significant residual hearing up to 50dB. CMV turns out to be a significant etiology of SNHL, first to date reported in the Korean pediatric population. Analysis of audiologic phenotypes showed a very wide spectrum of SNHL and favorable CI outcomes in case of profound deafness. Especially for the patients with asymmetric hearing loss, close surveillance of hearing should be warranted and CI could be considered on the worse side first, based on the observation of rapid progression to profound deafness of better side.</P>
Production of dehydrated fuel ethanol by pressure swing adsorption process in the pilot plant
Jun-Seong Jeong,Byung-Uk Jang,Young-Ran Kim,Gi-Wook Choi,Bong-Woo Chung 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.5
Fermented ethanol is gaining wide popularity as a car fuel additive. The pressure swing adsorption (PSA) process is attractive for the dehydration of bioethanol on the industrial scale, since its energy consumption is low and it is capable of producing a very pure product. 3 Å zeolite possesses micro-pores which, due to their small size, adsorb water molecules but not ethanol molecules. In this work, up to 2 kL/day of dehydrated ethanol (99.5% by weight) was successfully produced with 3 Å zeolite by the pressure swing adsorption process. The cycles of the PSA process were operated under the following variables: feed flow rate (27-62 N㎥/hr of 93.2% by weight), purge/feed ratio (30-24%), adsorption temperature (130-140℃) and adsorption pressure (1.2 atm).
Jun-Ran Kim,In-Hong Jeong,Sang-Guei Lee,Hyun Gwan Goh 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
The acaricidal activity of Asarum heterotropoides root-derived principles, methyleugenol, safrole, 3-carene, α-asarone, pentadecane and A. heterotropoides root steam distillate constituents was tested against poultry red mites Dermanyssus gallinae (De Geer). All active principles were identified by spectroscopic analysis. Results were compared with those of two conventional acaricides, benzyl benzoate and N,N-diethyl-3-methylbenzamide (DEET). Methyleugenol (24 h LC50 = 0.57 μg/cm2) and safrole (24 h LC50 = 8.54 μg/cm2) were the most toxic compounds toward D. gallinae, followed by 3,4,5-trimethoxytoluene, 3,5-dimethoxytoluene, estragole, α-terpineol, verbenone, eucarvone, linalool, and terpinen-4-ol (LC50 = 15.65–27.88 μg/cm2). Methyleugenol was 16.7× and 11.0× more toxic than benzyl benzoate (LC50 = 9.52 μg/cm2) and DEET (LC50 = 6.28 μg/cm2), respectively; safrole was 1.1× and 0.73× more toxic. Asarum heterotropoides root-derived materials, particularly methyleugenol and safrole, merit further study as potential acaricides. Global efforts to reduce the level of highly toxic synthetic acaricides in indoor environments justify further studies on A. heterotropoides root extract and steam distillate preparations containing the active constituents described as potential contact-action fumigants for the control of mites.
Kim, Su Ran,Lee, Hye Won,Jun, Ji Hee,Ko, Byoung-Seob KOREAN PHARMACOPUNCTURE INSTITUTE 2017 Journal of pharmacopuncture Vol.20 No.1
Objectives: Gan Mai Da Zao (GMDZ) decoction is widely used for the treatment of various diseases of the internal organ and of the central nervous system. The aim of this study is to investigate the effects of GMDZ decoction on neuropsychiatric disorders in an animal model. Methods: We searched seven databases for randomized animal studies published until April 2015: Pubmed, four Korean databases (DBpia, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, and Research Information Sharing Service), and one Chinese database (China National Knowledge Infrastructure). The randomized animal studies were included if the effects of GMDZ decoction were tested on neuropsychiatric disorders. All articles were read in full and extracted predefined criteria by two independent reviewers. Results: From a total of 258 hits, six randomized controlled animal studies were included. Five studies used a Sprague Dawley rat model for acute psychological stress, post-traumatic stress disorders, and unpredictable mild stress depression whereas one study used a Kunming mouse model for prenatal depression. The results of the studies showed that GMDZ decoction improved the related outcomes. Conclusion: Regardless of the dose and concentration used, GMDZ decoction significantly improved neuropsychiatric disease-related outcomes in animal models. However, additional systematic and extensive studies should be conducted to establish a strong conclusion.
Fumigant Toxicity of Plant Essential Oils to Camp corticalis (Diptera: Cecidomyiidae)
Jun-Ran Kim,Haribalan Perumalsamy,Bong ki Son,Young-Joon Ahn 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
The toxicity of 102 plant essential oils against third instars of cecidomyiid gall midge, Camptomyia corticalis, was examined using a vapor-phase mortality bioassay. Results were compared with that of a conventional insecticide dichlorvos. Based on 24 h LC50 values, all essential oils were less toxic than dichlorvos (LC50, 0.027 mg/cm3). The LC50 of caraway seed, armoise, sage (Clary), oreganum, lemongrass, niaouli, spearmint, cassia special, sage (Dalmatian), thyme red, bay, garlic, and pennyroyal essential oil is between 0.55–0.60 mg/cm3. The LC50 of cassia pure, thyme white, cassia redistilled, star anise, peppermint, wintergreen, cinnamon bark, majoram, chamomile romon, eucalyptus, rosemary, cedar wood, pimento berry, savory (summer), lavender, and coriander oil is between 0.61–0.99 mg/cm3. All other essential oils tested exhibited low toxicity to the cecidomyiid larvae (LC50,>0.99 mg/cm3). The active principles of active essential oils were identified by GC-MS analysis. The major active principles are such as pulegone, thujone, camphor, 1,8-cineole, a-pinene, thymol, menthol. At a rate of 5 mg/cm3, pulegone, and thujone, exhibited 100% morality whereas camphor, 1,8-cineole, α-pinene, thymol and menthol showed 90% mortality at 15 mg/cm3. Global efforts to reduce the level of highly toxic synthetic insecticides in the agricultural environment justify further studies on the essential oils and their constituents described as potential insecticides for the control of the mushroom fly as fumigants with contact action.
Enhanced Biodegradation of Environmental Allergen by a vgb-containing Burkholderia cepacia
Kim, Mi-Sun,Yoon, Suk-Ran,Jun, Woo-Jin,Park, So-Young,Yang, Young,Shim, Sang-In,Hwang, Kwang-Woo,Chung, Jin-Woong The Korean Society of Toxicogenomics and Toxicopro 2005 Molecular & cellular toxicology Vol.1 No.4
Using genetic engineering, the Vitreoscilla (bacterial) hemoglobin gene (vgb) was integrated stably into the chromosomes of and Burkholderia cepacia. Similar to previous results, the wild type VHb improved growth for Burkholderia cepacia and degradation of benzoic acid under both normal and low aeration conditions. The stable expression of VHb enhanced these parameters. The results demonstrate the possibility that the positive effects provided by VHb may be augmented by protein engineering.