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RISS 인기검색어
- 검색키워드
- 저자 : Julie Yu (검색결과 4 건)
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Julie Li-Yu,Sarath Lekamwasam 대한골다공증학회 2021 Osteoporosis and Sarcopenia Vol.7 No.3
Objectives: This study is designed to estimate appropriate intervention thresholds for the Philippines Fracture Risk Assessment Tool (FRAX) model to identify postmenopausal women with high fracture risk. Methods: Age dependent intervention thresholds were calculated for a woman of body mass index 25 kg/m2 aged 50e80 years with a previous fragility fracture without other clinical risk factors. Fixed thresholds were developed using a database of 1546 postmenopausal women who underwent dualenergy X-ray absorptiometry for clinical reasons. Major and hip fracture risks were estimated using clinical risk factors with and without bone mineral density (BMD) input. Women were categorized to high risk and low risk groups according to the age dependent thresholds. The best cut-points were determined considering the optimum sensitivity and specificity using receiver operating characteristic analysis. Results: The age dependent intervention thresholds of major fracture risk ranged from 2.8 to 6.9% while hip fracture risk ranged from 0.4 to 3.0% between 50 and 80 years of age. Major fracture threshold of 3.75% and hip fracture threshold of 1.25% were the best fixed thresholds observed and non-inclusion BMD in the fracture risk estimations did not change the values. As a hybrid method, 3% major fracture and 1% hip fracture risks for those < 70 years old and age-dependent thresholds for those aged 70 years and above can be recommended. Conclusions: The intervention thresholds estimated in the current study can be applied to identify Filipino postmenopausal women with a high fracture risk. Clinicians should decide on the type of thresholds most appropriate.
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( Yun Yu ),( Xiao Jun Ouyang ),( Qing-lin Lou ),( Liu Bao Gu ),( Yong Zhen Mo ),( Gary T. Ko ),( Chun Chung Chow ),( Wing Yee So ),( Ronald Ma ),( Alice Kong ),( Nicola Brown ),( Jennifer Nan ),( Juli 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.1
Background/Aims: The application of glycated hemoglobin (HbA1c) for the diagnosis of diabetes is currently under extensive discussion. In this study, we explored the validity of using HbA1c as a screening and diagnostic test in Chinese subjects recruited in Nanjing, China. Methods: In total, 497 subjects (361 men and 136 women) with fasting plasma glucose (PG) ≥ 5.6 mmol/L were recruited to undergo the oral glucose tolerance test (OGTT) and HbA1c test. Plasma lipid, uric acid, and blood pressure were also measured. Results: Using a receiver operating characteristic curve, the optimal cutoff point of HbA1c related to diabetes diagnosed by the OGTT was 6.3%, with a sensitivity and specificity of 79.6% and 82.2%, respectively, and the area under the curve was 0.87 (95% confidence interval, 0.83 to 0.92). A HbA1c level of 6.5% had a sensitivity and specificity of 62.7% and 93.5%, respectively. When comparing the HbA1c ≥ 6.5% or OGTT methods for diagnosing diabetes, the former group had significantly higher HbA1c levels and lower levels of fasting and 2-hour PG than the latter group. No significant difference was observed in the other metabolism indexes between the two groups. Conclusions: Our results suggest that HbA1c ≥ 6.5% has reasonably good specificity for diagnosing diabetes in Chinese subjects, which is in concordance with the American Diabetes Association recommendations.
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Conditioned medium from tonsil-derived mesenchymal stem cells promotes adiponectin production
Kim, Yu-Hee,Cho, Kyung-Ah,Park, Minhwa,Webster, Julie A.,Woo, So-Youn,Ryu, Kyung-Ha SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Mesenchymal stem cells (MSCs) are often considered to be a good source for the development of regenerative medicine. Previously, we reported that tonsil-derived MSC conditioned medium (T-MSC CM) produces visceral fat reducing effects. As reduced visceral adiposity is closely associated with an increase in circulating adiponectin, the present study investigated the effects of T-MSC CM on adiponectin production. T-MSC CM was collected from previously isolated and characterized T-MSCs and injected into senescence-accelerated mouse prone 6 mice, which exhibit characteristics of aging and obesity. The results demonstrated a reduction in mouse weight and epididymal adipose tissue (eAT) mass following injection of T-MSC CM. Significant increases in adiponectin expression in the eAT, and total and high molecular weight (HMW) adiponectin in the circulation were observed in the T-MSC CM-injected mice compared with control mice using reverse transcription-quantitative polymerase chain reaction, western blot analysis and ELISA. In 3T3-L1 adipocytes, T-MSC CM treatment increased adiponectin secretion and multimerization, as detected using western blotting under non-reducing and non-heat-denaturing conditions. Furthermore, glucose oxidase was used to induce oxidative stress in 3T3-L1 adipocytes and it was observed that T-MSC CM reduced reactive oxygen species production and the expression of certain oxidative stress markers. In addition, the results also demonstrated that the production of HMW adiponectin was increased, which indicates that T-MSC CM may enhance adiponectin multimerization via amelioration of oxidative stress. Further studies are required to elucidate anti-oxidant molecules secreted from T-MSCs, and these results highlight the potential therapeutic relevance of T-MSC CM for the treatment of obesity or obesity-associated diseases.</P>
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An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study
Ching-Lung Cheung,Seng Bin Ang,Manoj Chadha,Eddie Siu-Lun Chow,정윤석,Fen Lee Hew,Unnop Jaisamrarn,Hou Ng,Yasuhiro Takeuchi,Chih-Hsing Wu,Weibo Xia,Julie Yu,Saeko Fujiwara 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.1
Objectives: Hip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur in Asia. To date, only a few studies provided the updated projection, and none of them focused on the hip fracture projection in Asia. Thus, it is essential to provide the most up to date prediction of hip fracture in Asia, and to evaluate the total direct medical cost of hip fracture in Asia. Methods: We provide the updated projection of hip fracture in 9 Asian Federation of Osteoporosis Societies members using the most updated incidence rate and projected population size. Results: We show that the number of hip fracture will increase from 1,124,060 in 2018 to 2,563,488 in 2050, a 2.28-fold increase. This increase is mainly due to the changes on the population demographics, especially in China and India, which have the largest population size. The direct cost of hip fracture will increase from 9.5 billion United State dollar (USD) in 2018 to 15 billion USD in 2050, resulting a 1.59-fold increase. A 2%e3% decrease in incidence rate of hip fracture annually is required to keep the total number of hip fracture constant over time.
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