http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jose Couras da Silva-Filho (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Marcelo Bezerra Mendes,Jose Couras da Silva-Filho,Carla Kelly Barroso Sabino,Daniel Dias Rufino Arcanjo,Cleyton Marcos Melo Sousa,Isabella Cristhina Goncalves Costa,Mariana Helena Chaves,Rita de Ca´ss 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.10
Platonia insignis Mart. (Clusiaceae) is a medicinal plant from the Brazilian Amazon region. The present study evaluated the biological potential of the ethanol extract (Pi-EtOH) and ethyl acetate fraction (Pi-EtOAc) of the P. insignis fruit shells on the cardiovascular system of rats. Pi-EtOH or Pi-EtOAc (12.5, 25, and 50mg/kg) was administered intravenously in normotensive rats (260–300 g), and the mean arterial pressure and the heart rate were monitored. The Pi-EtOH induced hypotension ( - 11.56– 0.89, - 7.43– 0.85, and - 17.56– 1.97 mmHg) followed by bradycardia in two highest doses ( - 8.89– 3.62 and - 15.79– 1.83 beats/min) and Pi-EtOAc, at the same doses, induced hypotension ( - 11.2– 1.03, - 14.48– 1.13, - 29.89– 2.67 mmHg)more intensively, followedby tachycardia at thedose12.5and25mg/kg(15.64– 2.06, 19.31– 1.92 beats/min) and bradycardia at a dose of 50mg/kg (- 9.98– 7.33 beats/min). The hypotensive response from Pi-EtOAc was not attenuated when used in the pretreatment with L-NAME, verapamil, propranolol, and hexamethonium. However, when using yohimbine, the hypotensive effect was inhibited ( - 4.42– 1.28 (P< .05), - 3.29– 0.99 (P< .05), 2.06– 1.18 mmHg (P< .05); Student’s t-test). Hence, the Pi-EtOAc seems to act similarly to the a2-adrenergic agonist in this hypotensive effect.
-
Cardiovascular Effect of Diosgenin in Ovariectomized Rats
Ilmara Cecilia Pinheiro de Silva Morais,Iris Jordaˆnia Luz Moura,Carla Kelly Barroso Sabino,Lucas Antonio Duarte Nicolau,Fabiana de Moura Souza,Jose´ Couras da Silva-Filho,Rita de Ca´ssia Meneses Oliv 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.3
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200–220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10−9 M–3 × 10−4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55.34% ± 7.7% (in endothelium-intact rings) and Emax value of 30.30% ± 5.7% (in endothelium-denuded rings). In the endothelium-intact rings, the vasorelaxing effect of diosgenin was reduced by NG-nitro-l-arginine methyl ester (L-NAME) (100 μM), atropine (1 μM), indomethacin (10 μM), 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ) (10 μM), 4-aminopyridine (1 mM), tetraethylammonium (3 mM), glibenclamide (10 μM), apamin (10 μM), and Tiron (1 μM). Diosgenin (10−5 M) inhibited the contractions induced by cumulative addition of phenylephrine (10−9–10−5 M). The 28-days treatment with diosgenin (50 mg/kg, v.o.) did not imply changes in the myeloperoxidase parameter, but increased significantly, levels of glutathione, superoxide dismutase, and nitric oxide, as well as reduced the concentration of malondialdehyde related to lipid peroxidation. Our results suggest that diosgenin induced relaxation in aortic rings via an endothelium-dependent pathway, which involves the EDRF, the opening of potassium channels and antioxidant action.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
