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Joonbeom Kwon,김덕윤,조강준,Mamoru Hashimoto,Kanako Matsuoka,Tadanobu Kamijo,Zhou Wang,Sergei Karnup,Anne M. Robertson,Pradeep Tyagi,Naoki Yoshimura 대한배뇨장애요실금학회 2024 International Neurourology Journal Vol.28 No.-
Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses. Also, a series of local signals called autonomous myogenic contraction, micromotion, or afferent noises, which can occur during bladder filling, may be induced by the leak of acetylcholine (ACh) or urothelial release of adenosine triphosphate (ATP). They can be transmitted to the central nervous system through afferent fibers to trigger coordinated urgency-related detrusor contractions. Antimuscarinics, commonly known to induce smooth muscle relaxation by competitive blockage of muscarinic receptors in the parasympathetic postganglionic nerve, have a minimal effect on detrusor contraction within therapeutic doses. In fact, they have a predominant role in preventing signals in the afferent nerve transmission process. β3-adrenergic receptor (AR) agonists inhibit afferent signals by predominant inhibition of mechanosensitive Aδ-fibers in the normal bladder. However, in pathologic conditions such as spinal cord injury, it seems to inhibit capsaicin-sensitive C-fibers. Particularly, mirabegron, a β3-agonist, prevents ACh release in the BOO-induced detrusor overactivity model by parasympathetic prejunctional mechanisms. A recent study also revealed that vibegron may have 2 mechanisms of action: inhibition of ACh from cholinergic efferent nerves in the detrusor and afferent inhibition via urothelial β3-AR.
실내위치측위를 위한 Wi-Fi 및 BLE 핑거프린팅 성능 기술 분석
서효승 ( Hyo-seung Seo ),이도희 ( Dohee Lee ),이준범 ( Joonbeom Lee ),조주연 ( Juyeon Jo ),손봉기 ( Bong-ki Son ),이재권 ( Jae-kwon Lee ),송제민 ( Je-min Song ),이재호 ( Jaeho Lee ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.1
실내 위치 인식 기술은 여러 기술을 통해 시도되어 왔으며, 대표적인 기술로는 Wi-Fi 기반 위치 인식과 Bluetooth Low Energy 기반의 위치 인식이 있다. 하지만 Bluetooth Low Energy 는 10m 거리 밖에선 오차가 많아지고 정밀도가 낮아지는 특성으로 인해 Wi-Fi 가 보편화되었다. 본 논문에서는 핑거프린팅 기법을 이용하였을 때 Wi-Fi 와 Bluetooth Low Energy 의 위치 인식 기술의 성능 분석을 목적으로 기술되었다.