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Piroxicam - Cyclodextrin 포접화합물의 Suspension 에 대한 Bioavailavility 의 연구
김종갑(Johng - Kap Kim),박선희(Sun - Hee Park),김형민(Hyung - Min Kim) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
Inclusion complexes of piroxicam with α, β and γ-cyclodextrins were prepared and suspended to enhance the bioavailavility of piroxicam. A HPLC analysis was employed for the determination of piroxicam in the rabbit serum after a single oral dose in suspension of piroxicam and each of inclusion complexes of piroxicam with α, β and γ-cyclodextrins. The bioavailability and serum level of piroxicam from β-cyclodextrin inclusion complexes was higher than those of piroxicam and the other complexes administered, and the total area under the curve of serum concentration versus time for their inclusion complexes were larger than that of piroxicam.
Methampicillin Lysinate의 합성 및 항균작용
김종갑(Johng Kap Kim),이숙경(Sook Kyung Lee) 대한약학회 1977 약학회지 Vol.21 No.4
Since ampicillin, one of the important semi-synthetic derivatives of penicillins, is restricted in use because of its unfavorable physico-chemical and pharmacological properties, the author synthesized a new derivative, methampicillin lysinate and its physical and characteristics were determined. The antibacterial activity of this compound against ten species of Gram positive and negative bacteria in vitro showed that it was more active to Gram negative bacteria than the positive and that was three times more potent than ampicillin trihydrate.
Fenbufen 좌제의 물리화학적 특성 및 생체이용률에 관한 연구
김종갑 ( Kim Johng Kap ),홍순억 ( Hong Soun Uk ) 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
Suppositories containing Fenbufen were made by the Fusion method with Witepsol H-15, Wecobee and PEG 1540 bases. In order to produce an exact dosage form, displacement value-and other values were determined. The release rates were determined with the K. P. dissolution apparatus and with cellophane tube dialysis device and they were found to be; PEG 1540> Witepsol H-15> Wecobee. The bioavailability of Fenbufen after rectal administration was PEG 1540> Witepsol H-15> Wecobee which correlates with the in vitro release.
김종갑,최수일 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.1
Etilefrine hydrochloride was microencapsulated with ethylcellulose by phase separation method to develop a sustained release dosage form. The results of dissolution test carried out with various microcapsules showed that the drug release was decreased with increasing the particle size of microcapsules at a constant core to wall ratio, and with decreasing the core to wall ratio. Also ethylcellulose 50 cps and fast stirring rate (900 rpm) was better in decreasing the drug release than ethylcellulose 22 cps and slow stirring rate (300 rpm), respectively.
Fenbufen 좌제의 물리화학적 성상 및 생체이용률에 관한 연구
김종갑,홍순억 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.2
This investigation was designed to determine the release of fenbufen from suppositories and their bioavailability in rabbits. Suppositories containing fenbufen were made by the fusion method with Witepsol H-15, Wecobee and PEG 1540 base. Displacement value, weight variation, content uniformity, melting point and melting time were determined for preformulation of the fenbufen suppositories. The release rates were determined with the KP dissolution apparatus and with cellophane tube dialysis device and were increased in order of PEG 1540, Witespol H-15 and Wecobee. The bioavailabilities of fenbufen after rectal administration were also increased in order of PEG 1540, Witespol H-15 and Wecobee.
무모 마우스의 피부를 통한 항바이러스제의 투과와 Azone 의 영향
김종갑,최승호 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.4
1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous penetration of a number of different chemicals. BVDU and FEAU were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies through hairless mouse skin. This study demonstrates the value of penetration enhancing agent (Azone) and the need for a predictable evaluations in the development of topical antiviral agents.
Doxycycline Hyclate 및 Doxycycline - L methylenelysine 의 상대적 생체내이용률에 관한 연구
김종갑,최영욱 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100㎎ of doxycycline hyclate, were administered orally to 10 healthy male volunteers. Serum concentrations were determined periodically over 12 hrs by microbiological assay. Peak serum concentrations were reached within 4 hrs: doxycycline hyclate (1.38mcg·㎖^(-1)) gave 1.66 times higher concentration than that of doxycycline-L methylenelysine (0.83mcg·㎖^(-1)). And the areas under the serum concentration-time curves 0 to 12 hrs were 8.38mcg·hr·㎖^(-1) (doxycycline hyclate) and 5.56mcg·hr·㎖^(-1)(doxycycline-L methylenelysine).