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Qi Huang,Xiaohu Zhou,Jiyuan You,Shuaishuai Xu,Lushan Liu,Yang Wang 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.6
Since the Late Cenozoic, tectonic deformation has been intense in the Longxian–Baoji Fault Zone (LBFZ), which is at the intersection of the southwest margin of the Ordos Block, the northeast margin of the Tibet Plateau, and the Qinling Orogenic Belt. To evaluate the relative tectonic activity within the LBFZ and discuss the influence of the northeastward expansion of the Tibetan Plateau on the geomorphological evolution of the LBFZ, we extracted data of the Qianhe, Hengshuihe, and Jinlinghe River Basins from the ASTER GDEM and analyzed the geomorphic indices, including the hypsometric integral (HI), standardized stream length-gradient index (SL/K) and Hack profile, elongation ratio (Re), the drainage basin asymmetry factor (AF) and valley floor width-to-height ratio (VF). Through geomorphic indices and field investigations, we found that the LBFZ has experienced relatively high tectonic activity. Combined with the index of relative active tectonics (IAT), we compared the tectonic activity strengths of the four major faults in the study area. Among them, the tectonic activities of the Longxian-Qishan Fault (LQF) and the Taoyuan-Guichuansi Fault (TGF) are the highest. The morphology and AF values of the drainage basin of the southwest side of the study area indicate the influence of northwest-southeast compressive stress. The northeastward expansion of the Tibetan Plateau affected the LBFZ region, and the stress brought about by it controlled the tectonic deformation in the region and sculpted the modern landscape. This study is of great significance for understanding the impact of the northeastward expansion of the Tibetan Plateau on the geomorphological evolution of the LBFZ.
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Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass
Junbo Feng,Haiyuan Liu,Jiayi Chen,Jiyuan Wang,Zhuang Liu,Shenglin Ge 대한심장학회 2016 Korean Circulation Journal Vol.46 No.3
Background and Objectives: To explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine modelby determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, andperforming a histological evaluation. Materials and Methods: Thirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clampingcardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means controlgroup), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusionwith cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS(65 μg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusionwith LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 μg/kg) after aortic cross clamping. Lung tissueswere removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations. Results: In group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p<0.05). Comparedwith groups P and LSIV, the MDA concentration was lower in group LPS, while that of SOD was higher (p<0.05); Light and electronmicroscopy indicated that LS intervention reduced impairment of lung tissues. Conclusion: Our findings suggest that LS plays an important role in protecting lung tissues.
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( Ying Chen ),( Zhuying Liu ),( Fuxing Zhou ),( Hang Zhao ),( Qian Yang ),( Hua Li ),( Jiyuan Sun ),( Siwang Wang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5
Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.
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Chen, Ying,Liu, Zhuying,Zhou, Fuxing,Zhao, Hang,Yang, Qian,Li, Hua,Sun, Jiyuan,Wang, Siwang The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5
Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.
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