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프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성
최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.
류성만,전영태,이종욱,차진열 嶺南大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.17 No.-
The present study was conducted to determine the community structure in Whang river based on the benthic macroinvertebrates. The survey area included eight sites in Whang river and two sites in Nakdong river and the study was carried out from March of 1995 to February of 1996. The result are as follows; (1) Benthic mactoinvertebrates are composed of a total of 200 species including 114 genera, 71 families, 21 orders, 7 classes in five phyla. A total of 200 species was found in Whang river, however only 66 species were recorded in Nakdong river. 2) Species frequency was different depending on the study area. It ranged from 84-112 species in the upper stream(site 1 to 6) to 71-75 species in the lower stream(site 7 to 8) and 41-58 species in the Nakdong river(site 9 to 10). Taxa with highest species frequency were aquatic insecta. 3) Average number of individuals was 1656.5/0.5㎡ in the whole study aera. Inividual number was variable from 53/0.5㎡ at the site 8 to 296.8/0.5㎡ at the site 4. Taxa with highest individual species frequency were aquatic insecta. 4) Trichoptera and Ephemeroptera were dominant in upper stream, while Chironomidae was the most aboundant group in the lower stream. 5) Average dominance(DI), species richness(RI), species diversity(H'), and evenness(J') were 0.68, 2.71, 3.10 and 0.71, respectively, in the whole study area. The biotic indices in Whang river were relative higher than that of Nakdong river. 6) Functional feeding groups were collectors and shredder at site 1 to 6, filterer at site 7 to 10.
Quan, Lin-Hu,Piao, Jin-Ying,Min, Jin-Woo,Kim, Ho-Bin,Kim, Sang-Rae,Yang, Dong-Uk,Yang, Deok-Chun The Korean Society of Ginseng 2011 Journal of Ginseng Research Vol.35 No.3
Ginsenoside $Rb_1$ is the main component in ginsenosides. It is a protopanaxadiol-type ginsenoside that has a dammarane-type triterpenoid as an aglycone. In this study, ginsenoside $Rb_1$ was transformed into gypenoside XVII, ginsenoside Rd, ginsenoside $F_2$ and compound K by glycosidase from Leuconostoc mesenteroides DC102. The optimum time for the conversion was about 72 h at a constant pH of 6.0 to 8.0 and the optimum temperature was about $30^{\circ}C$. Under optimal conditions, ginsenoside $Rb_1$ was decomposed and converted into compound K by 72 h post-reaction (99%). The enzymatic reaction was analyzed by highperformance liquid chromatography, suggesting the transformation pathway: ginsenoside $Rb_1$ ${\rightarrow}$ gypenoside XVII and ginsenoside Rd${\rightarrow}$ginsenoside $F_2{\rightarrow}$compound K.
Hilbert-Huang Transformation based Solar Light Noise Suppression Method
QUAN Jin-guo,BAI Bo,ZHANG Hao,ZHANG Yan 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.6
Solar light noise, as the main part of channel noise in outdoor visible light communication (VLC) system, would easily saturate the photon-detector, and dramatically decrease the outdoor VLC system performance. A Hilbert-Huang Transformation based solar light noise suppression method is proposed in this paper, a background light noise measurement system is also designed and implemented to verify the noise suppression method's performance. And the measurement result shows that it could effectively reduce the solar light noise, and improve the VLC system’s stability and reliability.