In-situ synthesized ZnFe₂O₄ firmly anchored to the surface of MWCNTs as a long-life anode material with high lithium storage performance

Yang, Tianbo,Zhang, Wanxi,Li, Linlin,Jin, Bo,Jin, Enmei,Jeong, Sangmoon,Jiang, Qing Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.425 No.-

<P><B>Abstract</B></P> <P>Because of two different metal cations in the crystal structures, binary transition metal oxides possess a lot of unique properties. ZnFe<SUB>2</SUB>O<SUB>4</SUB> emerges from these transition metal oxides on account of its high theoretical capacity (1072mAhg<SUP>−1</SUP>). One-dimensional multi-walled carbon nanotubes (MWCNTs) would be a desirable conductive additive for ZnFe<SUB>2</SUB>O<SUB>4</SUB>, thereby improving the electrochemical performance of ZnFe<SUB>2</SUB>O<SUB>4</SUB>. In this work, we prepare ZnFe<SUB>2</SUB>O<SUB>4</SUB>/MWCNTs by solvothermal method with further heat-treatment. ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles are firmly anchored to the surface of MWCNTs. ZnFe<SUB>2</SUB>O<SUB>4</SUB>/MWCNTs nanocomposite displays high specific capacity (1278mAhg<SUP>−1</SUP> at a current density of 200mAg<SUP>−1</SUP> after 200 cycles, and 565mAhg<SUP>−1</SUP> at a current density of 1500mAg<SUP>−1</SUP> after 500 cycles), and good rate performance (367mAhg<SUP>−1</SUP> even at a current density of 6000mAhg<SUP>−1</SUP> after 80 cycles). The superior electrochemical performance may promote ZnFe<SUB>2</SUB>O<SUB>4</SUB> to be a promising alternative anode in lithium-ion batteries.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles and ZnFe<SUB>2</SUB>O<SUB>4</SUB>/MWCNTs composites have been prepared by a facile solvothermal method. </LI> <LI> ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles are firmly anchored to the surface of MWCNTs. MWCNTs can suppress the growth of ZnFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles. </LI> <LI> ZnFe<SUB>2</SUB>O<SUB>4</SUB>/MWCNTs nanocomposite displays high specific capacity at a high current density. </LI> </UL> </P>

Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis

Zhaoxia Wang,Zhenxing Zhang,Yanling Guo,Huifeng Shui,Guoqi Liu,Tianbo Jin,Huijie Wang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4

Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results: Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p< 0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40–3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31–4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55–5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63–9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p= 0.011). Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.

The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China

Liang Tiebiao,Liang Anshan,Zhang Xianbo,Wang Qi,Wu Haiqing,He Jun,Jin Tianbo 한국유전학회 2022 Genes & Genomics Vol.44 No.9

Background: Coronary heart disease (CHD) is a disease that seriously harms human health. Genetic factors seriously affect the CHD susceptibility. The CYP20A1, CYP4F2 and CYP2D6 are important drug metabolism enzymes in the human body. Objective: We aimed to explore the association between CYP20A1, CYP4F2, CYP2D6 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Methods: Based on the 'case-control' experimental design (505 cases and 508 controls), we conducted an association study between 5 candidate SNPs selected from CYP20A1 (rs2043449), CYP4F2 (rs2108622, rs3093106, rs309310), CYP2D6 (rs1065852) and CHD risk. Logistic regression was used to analyze the CHD susceptibility under different genetic models. Multi-factor dimensionality reduction (MDR) was used to analyze the interaction of 'SNP-SNP' in CHD risk. Results: Our results showed that under multiple genetic models, CYP2D6 rs1065852 significantly increased the CHD risk in these participants who are ≤ 60 years old (OR 1.40, CI 1.07-1.82, p = 0.013), smokers (OR 1.40, CI 1.02-1.93, p = 0.039), or have family history (OR 1.24, CI 1.02-1.51, p = 0.035). CYP4F2 SNPs rs2108622 (OR 0.63, CI 0.43-0.93, p = 0.020), rs3093106 (OR 0.52, CI 0.29-0.92, p = 0.023), and rs309310 (OR 0.55, CI 0.31-0.96, p = 0.033) were potentially associated with the course of CHD patients. Conclusion: Our study found that CY2D6 rs1065852 has an outstanding and significant association with increased CHD risk. Our study provided data supplements for CHD genetic susceptibility loci, and also provided a new and valuable reference for CHD drug treatment.

Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population

Huang Liang,Bai Fenghua,Zhang Yutian,Zhang Shanshan,Jin Tianbo,Wei Xingwei,Zhou Xiaoli,Lin Mei,Xie Yufei,He Chanyi,Lin Qi,Xie Tian,Ding Yipeng 한국유전학회 2022 Genes & Genomics Vol.44 No.8

Background: Thyroid hormones are critical regulators of metabolism, development and growth in mammals. However, the genetic association of thyroid-related hormones in the Chinese Han population is not fully understood. Objective: We aimed to identify the genetic loci associated with circulating thyroid-related hormones concentrations in the healthy Chinese Han population. Methods: Genotyping was performed in 124 individuals using Applied Biosystems™ Axiom™ PMDA, and 796,288 single nucleotide polymorphisms (SNPs) were available for the GWAS analysis. For replication, eleven SNPs were selected as candidate loci for genotyping by Agena MassARRAY platform in additional samples (313 subjects). The values of p < 5 × 10- 6 suggest a suggestively significant genome-wide association with circulating thyroid-related hormones concentrations. Results: We identified that rs11178277 (PTPRB, p = 4.88 × 10- 07) and rs7320337 (LMO7DN-KCTD12, p = 1.22 × 10- 06) were associated with serum FT3 level. Three SNPs (rs4850041 in LOC105373394-LINC01249: p = 3.55 × 10- 06, rs6867291 in LINC02208: p = 2.40 × 10- 06 and rs79508321 in WWOX: p = 3.35 × 10- 06) were related to circulating T3 level. Rs12474167 (LOC105373394-LINC01249, p = 1.65 × 10- 06) and rs1864553 (IWS1, p = 2.00 × 10- 06) were associated with circulating T4 concentration. The association with TGA concentration was for rs17163542 in DISP1 (p = 3.46 × 10- 06) and rs12601151 in NOG-C17orf67 (p = 2.72 × 10- 07). Two genome-level significant SNPs (rs2114707 in LINC01314, p = 1.69 × 10- 06 and rs12601151, p = 1.41 × 10- 07) associated with serum TMA concentration were identified. Moreover, rs6083269 (CST1-CST2, p = 3.36 × 10- 06) was a significant locus for circulating TSH level. In replication, rs12601151 in NOG-C17orf67 was still associated with serum TGA level (p = 0.012). Conclusions: The GWAS reported 11 new suggestively significant loci associated with circulating thyroid-related hormones levels among the Chinese Han population. These findings represented suggestively biological candidates for circulating thyroid-related hormones levels and provided new insights into the mechanisms of regulating serum TGA concentration.