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        Resveratrol promotes mitochondrial energy metabolism in exercise-induced fatigued rats

        Lou Xujia,Hu Yulong,Ruan Rong,Jin Qiguan 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.4

        BACKGROUND/OBJECTIVES: To investigate the effect and regulator y mechanism of resveratrol supplementation on the mitochondrial energy metabolism of rats with exercise- induced fatigue. MATERIALS/METHODS: Forty-eight Sprague-Dawley male rats were divided randomly into a blank control group (C), resveratrol group (R), exercise group (E), and exercise and resveratrol group (ER), with 12 rats in each group. Group ER and group E performed 6-wk swimming training with 5% wt-bearing, 60 min each time, 6 days a wk. Group ER was given resveratrol 50 mg/kg by gavage one hour after exercise; group R was only given resveratrol 50 mg/kg by gavage; group C and group E were fed normally. The same volume of solvent was given by gavage ever y day. RESULTS: Resveratrol supplementation could reduce the plasma blood urea nitrogen content, creatine kinase activity, and malondialdehyde content in the skeletal muscle, increase the total superoxide dismutase activity in the skeletal muscle, and improve the fatigue state. Resveratrol supplementation could improve the activities of Ca2+-Mg2+-ATPase, Na+-K+- ATPase, succinate dehydrogenase, and citrate synthase in the skeletal muscle. Furthermore, resveratrol supplementation could up-regulate the sirtuin 1 (SIRT1)-proliferator-activated receptor gamma coactivator-1α ( P G C -1 α)-nuclear respirator y factor 1 pathway. CONCLUSIONS: Resveratrol supplementation could promote mitochondrial biosynthesis via the SIRT1/PGC-1α pathway, increase the activity of the mitochondrial energy metabolism- related enzymes, improve the antioxidant capacity of the body, and promote recover y from exercise-induced fatigue.

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