http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jin Ohk Lee (검색결과 59 건)
- 무료
- 기관 내 무료
- 유료
-
이수진,박옥련 경성대학교 2001 論文集 Vol.22 No.1
After introducing color TV, the color was much more importent than ever and the intrest of make-up was increasing. So the conclusions of this study on the TV actress make-up which have an important effect on general public are as listed below. 1) The year of 1980∼1985, the concept of TV make-up was not established and make-up was only a part of appard. The clothes were more important than make-up. The make-up pattern was mainly to express the cyeline clearly and mouth naturally. The make-up for TV actress was similar at this time. 2) The year of 1986∼1990, although the interest of make-up was growing under the influence of economic booming, the concept was not established yet. However the more positive presentation was tested and deep color was used more frequently than before. 3) The year of 1991∼1995, the make-up was a frequently used word at theis time and drastic make-up was appeared. TV actress hired their own make-up artists and cubic make-up equipped with all factors was performed. 4) The year of 1996∼1999, the make-up which express one's individuality was used. The natural skin tone and nude make-up was popular. However cubic facial make-up was essential. 5) After introducing color TV, the lined and similar styled make-up was changed into cublic and colorful make-up considerin one's merit and demerit. 6) Skin tone was natural at anytime and we can see the changes of eyebrow make-up has been harmonized with the fashion and generally, lips make-up was natural form except the clearance of lip line. Cheek touch has been used constantly in order to express cubic facial and is a part given much weight in the make-up.
-
-
Jeong, Jin-Ok,Kim, Mee-Ohk,Kim, Hyongbum,Lee, Min-Young,Kim, Sung-Whan,Ii, Masaaki,Lee, Jung-uek,Lee, Jiyoon,Choi, Yong Jin,Cho, Hyun-Jai,Lee, Namho,Silver, Marcy,Wecker, Andrea,Kim, Dong-Wook,Yoon, Y Ovid Technologies Wolters Kluwer -American Heart A 2009 CIRCULATION - Vol.119 No.5
<P>BACKGROUND: Endothelial progenitor cells (EPCs) are known to promote neovascularization in ischemic diseases. Recent evidence suggested that diabetic neuropathy is causally related to impaired angiogenesis and deficient growth factors. Accordingly, we investigated whether diabetic neuropathy could be reversed by local transplantation of EPCs. METHODS AND RESULTS: We found that motor and sensory nerve conduction velocities, blood flow, and capillary density were reduced in sciatic nerves of streptozotocin-induced diabetic mice but recovered to normal levels after hind-limb injection of bone marrow-derived EPCs. Injected EPCs were preferentially and durably engrafted in the sciatic nerves. A portion of engrafted EPCs were uniquely localized in close proximity to vasa nervorum, and a smaller portion of these EPCs were colocalized with endothelial cells. Multiple angiogenic and neurotrophic factors were significantly increased in the EPC-injected nerves. These dual angiogenic and neurotrophic effects of EPCs were confirmed by higher proliferation of Schwann cells and endothelial cells cultured in EPC-conditioned media. CONCLUSIONS: We demonstrate for the first time that bone marrow-derived EPCs could reverse various manifestations of diabetic neuropathy. These therapeutic effects were mediated by direct augmentation of neovascularization in peripheral nerves through long-term and preferential engraftment of EPCs in nerves and particularly vasa nervorum and their paracrine effects. These findings suggest that EPC transplantation could represent an innovative therapeutic option for treating diabetic neuropathy.</P>
-
Seung Eun Lee,Jung Eun Jang,Hyun Sik Kim,Min Kyo Jung,Myoung Seok Ko,Mi-Ok Kim,Hye Sun Park,Wonil Oh,Soo Jin Choi,Hye Jin Jin,Sang-Yeob Kim,Yun Jae Kim,Seong Who Kim,Min Kyung Kim,Chang Ohk Sung,Chan- 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The administration of mesenchymal stem cells (MSCs) was shown to attenuate overt as well as early diabetic nephropathy in rodents, but the underlying mechanism of this beneficial effect is largely unknown. Inflammation and mitochondrial dysfunction are major pathogenic factors in diabetic nephropathy. In this study, we found that the repeated administration of MSCs prevents albuminuria and injury to tubular epithelial cells (TECs), an important element in the progression of diabetic nephropathy, by improving mitochondrial function. The expression of M1 macrophage markers was significantly increased in diabetic kidneys compared with that in control kidneys. Interestingly, the expression of arginase-1 (Arg1), an important M2 macrophage marker, was reduced in diabetic kidneys and increased by MSC treatment. In cultured TECs, conditioned media from lipopolysaccharide-activated macrophages reduced peroxisomal proliferator-activated receptor gamma coactivator 1α (Pgc1a) expression and impaired mitochondrial function. The coculture of macrophages with MSCs increased and decreased the expression of Arg1 and M1 markers, respectively. Treatment with conditioned media from cocultured macrophages prevented activated macrophage-induced mitochondrial dysfunction in TECs. In the absence of MSC coculture, Arg1 overexpression in macrophages reversed Pgc1a suppression in TECs. These observations suggest that MSCs prevent the progression of diabetic nephropathy by reversing mitochondrial dysfunction in TECs via the induction of Arg1 in macrophages.
-
<i>trans</i>-Stilbenoids: potent and selective inhibitors for human cytochrome P450 1B1
Chun, Young-Jin,Lim, Chaemin,Ohk, Seul Ong,Lee, Ji Min,Lee, Jin Hee,Choi, Sun,Kim, Sanghee Royal Society of Chemistry 2011 MedChemComm Vol.2 No.5
<P>On the basis of our previous insights into the structural requirements of stilbenoids for the inhibition of cytochrome P450 1B1 (CYP1B1), a series of 2,4-dimethoxy group-containing stilbenes was prepared and evaluated for their inhibitory effects on the activity of CYP1s with the ultimate goal of identifying a potent and selective CYP1B1 inhibitor. Among the thirteen derivatives prepared, five compounds exhibited similar or greater potency compared to the previous lead compound, 2,4,3′,5′-tetramethoxystilbene (2,4,3′,5′-TMS), in inhibiting CYP1B1. In particular, 2,2′,3′,4,6′-pentamethoxystilbene was found to be a more selective and more potent CYP1B1 inhibitor than 2,4,3′,5′-TMS. 2,4,2′,6′-TMS showed remarkably potent inhibitory activity against CYP1B1 (IC<SUB>50</SUB> = 1.77 ± 0.14 nM) and also had a very high selectivity toward CYP1 isoenzymes. Molecular modeling was performed to determine the key molecular interactions with the CYP1B1 and CYP1A2 structures. On the basis of these structural and biological studies, the design of more potent and more selective drug-like derivatives can be envisaged.</P> <P>Graphic Abstract</P><P>The inhibitory potency and selectivity against cytochrome P450 subfamily 1 (CYP1) depends strongly on the substitution pattern. 2,2′,3′,4,6′-Pentamethoxystilbene was found to be the most selective and potent CYP1B1 inhibitor to date. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00242a'> </P>
-
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
Seong, Sook Jin,Kang, Woo Youl,Heo, Jae-Kyung,Jo, Jungjae,Choi, Won Gu,Liu, Kwang-Hyeon,Lee, Sangkyu,Choi, Min-Koo,Han, Yong-Hae,Lee, Hye Suk,Ohk, Boram,Lee, Hae Won,Song, Im-Sook,Yoon, Young-Ran Elsevier 2018 Clinical therapeutics Vol.40 No.8
<P><B>Abstract</B></P> <P> <B> Purpose:</B> Red ginseng is one of the world's most popular herbal medicines; it exhibits a wide range of pharmacologic activities and is often co-ingested with other herbal and conventional medicines. This open-label, randomized, 3-period study investigated the in vivo herb–drug interaction potential for red ginseng extract with cytochrome P-450 (CYP) enzymes and organic anion-transporting polypeptide (OATP) 1B1.</P> <P> <B>Methods:</B> Fifteen healthy male volunteers (22-28 years; 57.1-80.8 kg) were administered a single dose of cocktail probe substrates (caffeine 100 mg, losartan 50 mg, omeprazole 20 mg, dextromethorphan 30 mg, midazolam 2 mg, and pitavastatin 2 mg) and single or multiple doses of red ginseng extract for 15 days.</P> <P> <B>Findings:</B> The pharmacokinetic profiles of the probe substrates and metabolites after single- or multiple-dose administration of red ginseng extracts were comparable to the corresponding profiles of the control group. The geometric mean ratio of AUC<SUB>0–t</SUB> and 90% CIs for the probe substrate drugs between the control and multiple doses of red ginseng for 15 days were within 0.8 to 1.25 (CYP2C9, CYP3A4, and OATP1B1 probe substrates) or slightly higher (CYP1A2, CYP2C19, and CYP2D6 probe substrates). Additional assessments of the in vitro drug interaction potential of red ginseng extracts and the ginsenoside Rb1 on drug-metabolizing enzymes and transporters using human liver microsomes, cryopreserved human hepatocytes, and transporter-overexpressed cells were negative.</P> <P> <B>Implications:</B> Red ginseng poses minimal risks for clinically relevant CYP- or OATP-mediated drug interactions and is well tolerated. Clinical Research Information Service registry no.:</P>
-
Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate
Lee, Hae Won,Seong, Sook Jin,Ohk, Boram,Kang, Woo Youl,Gwon, Mi-Ri,Kim, Bo Kyung,Kim, Hyun-Ju,Yoon, Young-Ran Dove Medical Press 2017 Drug design, development and therapy Vol.11 No.-
<P><B>Objective</B></P><P>This study evaluated the pharmacokinetics (PKs) and safety of a newly developed β-lapachone (MB12066) tablet, a natural NAD(P)H:quinone oxidoreductase 1 (NQO1) substrate, in healthy male volunteers.</P><P><B>Methods</B></P><P>In a randomized, double-blind, multiple-dose, two-treatment study, 100 mg MB12066 or placebo was given twice daily for 8 days to groups of eight or three fasted healthy male subjects, respectively, followed by serial blood sampling. Plasma concentrations for β-lapachone were determined using liquid chromatography–tandem mass spectrometry. PK parameters were obtained with non-compartmental analysis. Tolerability was assessed based on physical examinations, vital signs, clinical laboratory tests, and electrocardiograms.</P><P><B>Results</B></P><P>Following a single 100 mg MB12066 oral dose, maximum plasma concentration (<I>C</I><SUB>max</SUB>) of β-lapachone was 3.56±1.55 ng/mL, and the median (range) time to reach <I>C</I><SUB>max</SUB> was 3 h (2–5 h). After the 8 days of 100 mg twice daily repeated dosing was completed, mean terminal half-life was determined to be 18.16±3.14 h, and the mean area under the plasma concentration vs time curve at steady state was 50.44±29.68 ng·h/mL. Accumulation index was 2.72±0.37. No serious adverse events (AEs) were reported, and all reported intensities of AEs were mild.</P><P><B>Conclusion</B></P><P>The results demonstrated that MB12066 was safe and well tolerated in healthy volunteers and that there were no serious AEs. Accumulation in plasma with twice-daily administration was associated with a 2.72 accumulation ratio.</P>
-
Lee, Eun-Chang,Ohk, Seul-Ong,Suh, Bo-Young,Park, Na-Hee,Kim, Beom-Joon,Kim, Dong-Hak,Chun, Young-Jin Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.1
The Malassezia fungi are responsible for various human skin disorders including dandruff and seborrheic dermatitis. Of the Malassezia fungi, Malassezia globosa (M. globosa) is one of the most common in human scalp. The completed genome sequence of M. globosa contains four putative cytochrome P450 genes. To determine the roles of Malassezia P450 enzymes in the biosynthesis of ergosterol, we isolated MGL3996 gene from M. globosa chromosomal DNA by PCR. The MGL3996 gene encodes an enzyme of 616 amino acids, which shows strong similarity with known CYP52s of other species. MGL3996 gene was cloned and expressed in Pichia pastoris (P. pastoris) heterologous yeast expression system. Using the yeast microsomes expressing MGL3996 protein, a typical P450 CO-difference spectrum was shown with absorption maximum at 448 nm. SDS-PAGE analysis revealed a protein band of apparent molecular weight 69 kDa and Western blot with anti-histidine tag antibody showed that MGL3996 was successfully expressed in P. pastoris. Cloning and expression of a new P450 gene is an important step to study the P450 monooxygenase system of M. globosa and to understand the role of P450 enzymes in pathophysiology of dandruff.
-
Lee, Seung Hun,Li, Can,Lim, Sun Woo,Ahn, Kyung Ohk,Choi, Bum Soon,Kim, Yong Soo,Moon, In Sung,Kim, Jin,Bang, Byung Kee,Yang, Chul Woo S. Karger AG 2005 American journal of nephrology Vol.25 No.1
<P><I>Background:</I> Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. <I>Methods:</I> CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently administered at a dose of 100 units/kg (thrice weekly). Effects of rHuEPO on CsA-induced renal injury were evaluated with tubulointerstitial fibrosis (TIF) score, macrophage infiltration, expression of proinflammatory and profibrotic cytokines, and apoptotic cell death. <I>Results:</I> Administration of rHuEPO decreased TIF score and the number of macrophages, which increased significantly in CsA-treated rat kidneys. At the molecular level, rHuEPO treatment decreased proinflammatory mediators (osteopontin and C-reactive protein) and profibrotic mediators (transforming growth factor-β1 and transforming growth factor-β1-inducible gene-h3). Increased apoptotic cell death in CsA-treated rat kidneys was significantly decreased with rHuEPO cotreatment, and apoptosis-related genes were regulated in favor of cell survival (increased Bcl-2 and suppressed caspase-3). <I>Conclusion:</I> rHuEPO has a renoprotective effect against chronic CsA-induced renal injury.</P><P>Copyright © 2005 S. Karger AG, Basel</P>
-
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
