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Jianxue Liu,Yonghao Ji,Hong Ai,Bo Ning,Junzhi Zhao,Yaoren Zhang,Guoliang Dun 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.3
Objective: To compare several noninvasive indices of fibrosis in chronic viral hepatitis B, including liver shear-wave velocity (SWV), hyaluronic acid (HA), collagen type IV (CIV), procollagen type III (PCIII), and laminin (LN). Materials and Methods: Acoustic radiation force impulse (ARFI) was performed in 157 patients with chronic viral hepatitis B and in 30 healthy volunteers to measure hepatic SWV (m/s) in a prospective study. Serum markers were acquired on the morning of the same day of the ARFI evaluation. Receiver operating characteristic (ROC) analysis was performed to evaluate and compare the accuracies of SWV and serum markers using METAVIR scoring from liver biopsy as a reference standard. Results: The most accurate test for diagnosing fibrosis F ≥ 1 was SWV with the area under the ROC curve (AUC) of 0.913, followed by LN (0.744), HA (0.701), CIV (0.690), and PCIII (0.524). The best test for diagnosing F ≥ 2 was SWV (AUC of 0.851), followed by CIV (0.671), HA (0.668), LN (0.562), and PCIII (0.550). The best test for diagnosing F ≥ 3 was SWV (0.854), followed by CIV (0.693), HA (0.675), PCIII (0.591), and LN (0.548). The best test for diagnosing F = 4 was SWV (0.965), followed by CIV (0.804), PCIII (0.752), HA (0.744), and LN (0.662). SWV combined with HA and CIV did not improve diagnostic accuracy (AUC = 0.931 for F ≥ 1, 0.863 for F ≥ 2, 0.855 for F ≥ 3, 0.960 for F = 4). Conclusion: The performance of SWV in diagnosing liver fibrosis is superior to that of serum markers. However, the combination of SWV, HA, and CIV does not increase the accuracy of diagnosing liver fibrosis and cirrhosis.
The topographic effect of ground motion based on Spectral Element Method
Liu, Xinrong,Jin, Meihai,Li, Dongliang,Hu, Yuanxin,Song, Jianxue Techno-Press 2017 Geomechanics & engineering Vol.13 No.3
A Spectral Element Method for 3D seismic wave propagation simulation is derived based on the three-dimensional fluctuating elastic dynamic equation. Considering the 3D real terrain and the attenuation characteristics of the medium, the topographic effect of Wenchuan earthquake is simulated by using the Spectral Element Method (SEM) algorithm and the ASTER DEM model. Results show that the high PGA (peak ground acceleration) region was distributed along the peak and the slope side away from the epicenter in the epicenter area. The overall distribution direction of high PGA and high PGV (peak ground velocity) region is parallel to the direction of the seismogenic fault. In the epicenter of the earthquake, the ground motion is to some extent amplified under the influence of the terrain. The amplification effect of the terrain on PGA is complicated. It does not exactly lead to amplification of PGA at the ridge and the summit or attenuation of PGA in the valley.
Yuanyuan Liu,Junyong Zhou,Jianxu Su,Junping Zhang 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.4
The existing concrete bridges are time-varying working systems, where the maintenance strategy should be planned according to the time-varying performance of the bridge. This work proposes a time-dependent residual capacity assessment procedure, which considers the non-stationary bridge load effects under growing traffic and non-stationary structural deterioration owing to material degradations. Lifetime bridge load effects under traffic growth are predicated by the nonstationary peaks-over-threshold (POT) method using time-dependent generalized Pareto distribution (GPD) models. The nonstationary structural resistance owing to material degradation is modeled by incorporating the Gamma deterioration process and field inspection data. A three-span continuous box-girder bridge is illustrated as an example to demonstrate the application of the proposed procedure, and the time-varying reliability indexes of the bridge girder are calculated. The accuracy of the proposed non-stationary POT method is verified through numerical examples, where the shape parameter of the time-varying GPD model is constant but the threshold and scale parameters are polynomial functions increasing with time. The case study illustrates that the residual flexural capacities show a degradation trend from a slow decrease to an accelerated decrease under traffic growth and material degradation. The reliability index for the mid-span cross-section reduces from 4.91 to 4.55 after being in service for 100 years, and the value is from 4.96 to 4.75 for the mid-support cross-section. The studied bridge shows no safety risk under traffic growth and structural deterioration owing to its high design safety reserve. However, applying the proposed numerical approach to analyze the degradation of residual bearing capacity for bridge structures with low safety reserves is of great significance for management and maintenance.