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Jiali Du,Feng Wu,Xiaoxun Ma 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
Influences of integral multi jet(IMJ), swirling blade nozzle(SBN) and longitudinal vortex generators(LVGs)on uniform mixing behaviors of ternary mixture during water vaporization in spouted beds were simulatedfrom the perspective of temperature and velocity fields. To quantitative evaluate the mechanism ofwater vaporization, temperature uniformity index(Tu), mixing index(IM) and coefficient of variation(CV)were used. Simulation results: the bubble-like distribution of particles caused by LVGs, IMJ and SBNstrengthen the gas–solid radial mixing and improve flow ‘‘dead zone”. In the upper of system, the promotionof uniformity and mixing quality is SBN > LVGs > IMJ, and LVGs has the most obvious promotingeffect on Tu. Moreover, the influences of operating parameters on Tu, IM and mass fraction of H2O(g)(MFH) were investigated. Vgas = 11.2 m/s, Tgas = 520 K, and TWater = 300 K, the liquid–solid mixing qualityis the best. In terms of Tu and MFH, Vgas = 11.2 m/s, Tgas = 540 K, and Twater = 400 K have the most obviouseffect.
Chunyang Ma,Zhuori Li,Jiali Wei,Feng Zhan,Ru Wang,Keying Fu,Xiaoping Wan 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.3
Purpose: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular adaptation to hypoxia,regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. The present study set out to characterize urinary HIF-1alpha expressions in patients with lupus nephritis (LN) and to explore whether urinary HIF-1alpha expressions are associated with histologic chronicity changes and renal function. Materials and Methods: Urinary HIF-1alpha levels were measured by enzyme-linked immunosorbent assays in 42 patients with LN and in 30 healthy controls. Activity and chronicity indexes as well as tubular HIF-1alpha expressions were analyzed for each specimen. Results: Urinary HIF-1alpha levels were higher in LN patients than in healthy controls (3.977±1.696 vs. 2.153±0.554 ng/mL, p<0.001) and were associated with histologic chronicity indexes (r=0.463, p<0.01) and eGFR (r=-0.324, p<0.05). However, urinary HIF-1alpha levels showed no correlation with histologic activity indexes, anti-dsDNA, ANA, complement 3 and 4 levels, proteinuria, systemic lupus erythematosis disease activity index, and WHO pathological classification (p>0.05). Conclusion: Urinary HIF-1alpha levels were elevated in LN patients and were associated with histologic chronicity changes and renal function, indicating that HIF-1alpha might contribute to histologic chronicity in LN.