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- 저자 : Jiajing Sun (검색결과 2 건)
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Yanjun Lu,Jiajing Sun,Xiaoyu Wu,Fumin Chen 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.2
The electrical discharge is able to realize efficient dressing for metal-bonded diamond wheel, but the monitoring and prediction of dressing status have been technical bottleneck in industrialization. Hence, the metal bond removal model of impulse spark and arc discharges is proposed to realize on-line monitoring and prediction for micro grain protrusion on diamond grinding wheel surface. The relationship between microremovals of metal bond and impulse spark and arc discharge parameters was investigated for controllable dressing. First, the static and dynamic impulse discharge experiments were carried out to reveal metal bond removal mechanisms of impulse spark and arc discharges; then the relationship between characterized impulse discharge parameters and removal of metal bond was quantitatively analyzed; finally, the dry electro-contact discharge (ECD) dressed coarse diamond wheels were applied to perform smooth surface and mirror grinding of optical glass and mold steels against mechanical dressed wheels. It is found that the critical transition value of arc discharge to spark discharge under static discharge and dynamic discharge conditions were 0.059 and 0.038, respectively. In comparison with mechanical dressing, the dry ECD can obtain higher grain protrusion height to improve ground surface quality, leading to a microscopic smooth surface of BAK3 optical glass and macroscopic mirror-like surface of model steels. It is confirmed that the established relationship model can be effectively used to on-line predict the removal of metal bond with the average prediction error of 10.1% and microscopic grain protrusion by characterized impulse discharge parameters.
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Dihydroartemisinin inhibits HepG2.2.15 proliferation by inducing cellular senescence and autophagy
( Jiang Zou ),( Qiang Ma ),( Ru Sun ),( Jiajing Cai ),( Hebin Liao ),( Lei Xu ),( Jingruo Xia ),( Guangcheng Huang ),( Lihua Yao ),( Yan Cai ),( Xiaowu Zhong ),( Xiaolan Guo ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.8
Dihydroartemisinin (DHA) has been reported to possess anti-cancer activity against many cancers. However, the pharmacologic effect of DHA on HBV-positive hepatocellular carcinoma (HCC) remains unknown. Thus, the objective of the present study was to determine whether DHA could inhibit the proliferation of HepG2.2.15 cells and uncover the underlying mechanisms involved in the effect of DHA on HepG2.2.15 cells. We found that DHA effectively inhibited HepG2.2.15 HCC cell proliferation both in vivo and in vitro. DHA also reduced the migration and tumorigenicity capacity of HepG2.2.15 cells. Regarding the underlying mechanisms, results showed that DHA induced cellular senescence by up-regulating expression levels of proteins such as p-ATM, p-ATR, γ-H<sub>2</sub>AX, P53, and P21 involved in DNA damage response. DHA also induced autophagy (green LC3 puncta gathered together and LC3II/LC3I ratio increased through AKT-mTOR pathway suppression). Results also revealed that DHA-induced autophagy was not linked to senescence or cell death. TPP1 (telomere shelterin) overexpression could not rescue DHA-induced anticancer activity (cell proliferation). Moreover, DHA down-regulated TPP1 expression. Gene knockdown of TPP1 caused similar phenotypes and mechanisms as DHA induced phenotypes and mechanisms in HepG2.2.15 cells. These results demonstrate that DHA might inhibit HepG2.2.15 cells proliferation through inducing cellular senescence and autophagy. [BMB Reports 2019; 52(8): 520-525]
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