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Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4
Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.
Recovery of mortar-aggregate interface of fire-damaged concrete after post-fire curing
Lang Li,Hong Zhang,Jiangfeng Dong,Hongen Zhang,Pu Jia,Qingyuan Wang,Yongjie Liu 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.3
In order to investigate the strength recovery of fire-damaged concrete after post-fire curing, concrete specimens were heating at 2°C/min or 5°C/min to 400, 600 and 800°C, and these exposed specimens were soaked in the water for 24 hours and following by 29-day post-fire curing. The compressive strength and split tensile strength of the high-temperature-exposed specimens before and after post-fire curing were tested. The proportion of split aggregate in the split surfaces was analyzed to evaluate the mortar-aggregate interfacial strength. After the post-fire curing process, the split tensile strength of specimens exposed to all temperatures was recovered significantly, while the recovery of compressive strength was only obvious within the specimens exposed to 600°C. The tensile strength is more sensitive to the mortar-aggregate interfacial cracks, which caused that the split tensile strength decreased more after high-temperature exposure and recovery more after post-fire curing than the compressive strength. The mortar-aggregate interfacial strength also showed remarkable recovery after post-fire curing, and it contributed to the recovery of split tensile strength.