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최은정,양정남 동신대학교 2005 論文集 Vol.15 No.-
The purpose of this study is to investigate the problems and implications of case management at alcohol counseling centers in Korea. In order to achieve these objectives a literature review and survey were undertaken. A total of 25 alcohol counselling centers were involved in the study and 79 professionals who were working in the alcoholic counselling centerer responded to a questioner. The result of the study shows that most professionals reported that case management is a very important and effective approach compared with other methods of treatment. They also reported that there is a need for further training and education on case management. Furthermore, even thought most of the respondents have less than two years experience in this field they have twice the number of case work as they had envisaged. These results reflect the following policy implications: First, a case manager in an alcoholic counselling centre require education and training which should be the responsibility of the ministry of health. Professionals should have a masters degree and at least a basic training in mental health. Training and clinical experiences on case management are also an necessity. Second, development of a clinical procedure together with a systematic diagnostic criteria for case management need to be in place. Third, Networking and cooperating with other mental health centers in the local area are important aspects to be considered.
The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression
Yang, Yong-Jin,Han, Jeung-Whan,Youn, Hong-Duk,Cho, Eun-Jung Oxford University Press 2010 Nucleic acids research Vol.38 No.2
<P>Parafibromin, a component of the RNA polymerase II-associated PAF1 complex, is a tumor suppressor linked to hyperparathyroidism-jaw tumor syndrome and sporadic parathyroid carcinoma. Parafibromin induces cell cycle arrest by repressing cyclin D1 via an unknown mechanism. Here, we show that parafibromin interacts with the histone methyltransferase, SUV39H1, and functions as a transcriptional repressor. The central region (128–227 amino acids) of parafibromin is important for both the interaction with SUV39H1 and transcriptional repression. Parafibromin associated with the promoter and coding regions of cyclin D1 and was required for the recruitment of SUV39H1 and the induction of H3 K9 methylation but not H3 K4 methylation. RNA interference analysis showed that SUV39H1 was critical for cyclin D1 repression. These data suggest that parafibromin plays an unexpected role as a repressor in addition to its widely known activity associated with transcriptional activation. Parafibromin as a part of the PAF1 complex might downregulate cyclin D1 expression by integrating repressive H3 K9 methylation during transcription.</P>
Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition.
Yang, Jae-Hyun,Song, Yunkyoung,Seol, Ja-Hwan,Park, Jin Young,Yang, Yong-Jin,Han, Jeung-Whan,Youn, Hong-Duk,Cho, Eun-Jung National Academy of Sciences 2011 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.108 No.1
<P>In mammals, the canonical histone H3 and the variant H3.3 are assembled into chromatin through replication-coupled and replication-independent (RI) histone deposition pathways, respectively, to play distinct roles in chromatin function. H3.3 is largely associated with transcriptionally active regions via the activity of RI histone chaperone, HIRA. However, the precise role of the RI pathway and HIRA in active transcription and the mechanisms by which H3.3 affects gene activity are not known. In this study, we show that HIRA is an essential factor for muscle development by establishing MyoD activation in myotubes. HIRA and Asf1a, but not CHD1 or Asf1b, mediate H3.3 incorporation in the promoter and the critical upstream regulatory regions of the MyoD gene. HIRA and H3.3 are required for epigenetic transition into the more permissive chromatin structure for polymerase II recruitment to the promoter, regardless of transcription-associated covalent modification of histones. Our results suggest distinct epigenetic management of the master regulator with RI pathway components for cellular differentiation.</P>