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Combinatorial patterns of histone acetylations and methylations in the human genome
Wang, Zhibin,Zang, Chongzhi,Rosenfeld, Jeffrey A,Schones, Dustin E,Barski, Artem,Cuddapah, Suresh,Cui, Kairong,Roh, Tae-Young,Peng, Weiqun,Zhang, Michael Q,Zhao, Keji Nature Publishing Group 2008 Nature genetics Vol.40 No.7
Histones are characterized by numerous posttranslational modifications that influence gene transcription. However, because of the lack of global distribution data in higher eukaryotic systems, the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined. Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4<SUP>+</SUP> T cells. Our data indicate that a large number of patterns are associated with promoters and enhancers. In particular, we identify a common modification module consisting of 17 modifications detected at 3,286 promoters. These modifications tend to colocalize in the genome and correlate with each other at an individual nucleosome level. Genes associated with this module tend to have higher expression, and addition of more modifications to this module is associated with further increased expression. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.
( Jeffrey Samuel Co ),( Chih-chi ),( Wang ),( Chih-che Lin ),( Chee-chien Yong ),( Chao Long Chen ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Alcoholic liver disease (ALD) has been a growing indication for living donor liver transplantation (LDLT) in Asia but certain medical, ethical and psycho-social issues question its appropriateness. Reports on long-term outcomes of LDLT for ALD are also scarce and so our aim was to report our center’s experience for the past 15 years and how LDLT has evolved to be the treatment of choice for end-stage liver disease secondary to ALD in a high volume center. Methods: A total of 1,384 consecutive LDLT was performed from January 2003 to August 2016 at Kaohsiung Chang Gung Memorial Hospital, and 87 patients had a pre-operative diagnosis of alcoholic liver disease (ALD) with or without hepatocellular carcinoma (HCC). This group was systematically matched with non-ALD (NALD) patients in a ratio of 1:2 using equiprobability method. Overall patient survival was compared using Kaplan-Meier analysis, and incidences of post-transplant De novo malignancy and alcohol relapse were described. Results: Patient demographics were comparable, as well as preoperative and intra-operative data. Of the 87 patients in the ALD group, 26 (30%) had concomitant HCC. Median follow- up for this study was 50 months. Overall patient survival at 1, 3 and 5 years for ALD were 98%, 97% and 92% respectively, while the NALD group had similar survival rates (P =0.282). The rate for De novo malignancy was 6% while that for recidivism was 7% despite only 76% of the patients meeting the 6 months abstinence rule. Conclusions: Results from our center show that LDLT for ALD has comparable short and longterm outcomes when compared to NALD, and the close relationship between donor and recipient seems to positively affect alcohol relapse rate and patient compliance to medication.
Exploration of power take off in wave energy converters with two-body interaction
Wang, Hao,Sitanggang, Khairil,Falzarano, Jeffrey Techno-Press 2017 Ocean systems engineering Vol.7 No.2
The study explores a novel design of wave energy converter (WEC) that utilizes the interaction between an inside heaving vertical cylinder with an outside fixed hollow cylinder. This design originates from the oscillating water column (OWC) type WEC but replaces the pneumatic power take off (PTO) through the Wells turbine with the hydrodynamic PTO through the inside heaving cylinder. To effectively evaluate the maximum power output, the system has been modeled in the hydrodynamic software AQWA (developed by ANSYS Inc) that has accumulated extensive offshore industry users. Ranges of the PTO parameters have been examined to make sure that proper linear damping can be implemented to simulate the PTO force. Comparing the efficiency of the pneumatic PTO with the hydrodynamic PTO, it appears that the hydrodynamic PTO is more promising than the traditional Wells turbine for an OWC system.
Energy extraction from the motion of an oscillating water column
Wang, Hao,Falzarano, Jeffrey M. Techno-Press 2013 Ocean systems engineering Vol.3 No.4
An Oscillating Water Column (OWC) is a relatively practical and convenient device that converts wave energy to a usable form, which is electricity. The OWC is kept inside a fixed truncated vertical cylinder, which is a hollow structure with one open end submerged in the water and with an air turbine at the top. This research adopts potential theory and Galerkin methods to solve the fluid motion inside the OWC. Using an air-water interaction model, OWC design for energy extraction from regular wave is also explored. The hydrodynamic coefficients of the scattering and radiation potentials are solved for using the Galerkin approximation. The numerical results for the free surface elevation have been verified by a series of experiments conducted in the University of New Orleans towing tank. The effect of varying geometric parameters on the response amplitude operator (RAO) of the OWC is studied and modification of the equation for evaluating the natural frequency of the OWC is made. Using the model of air-water interaction under certain wave parameters and OWC geometric parameters, a computer program is developed to calculate the energy output from the system.
Image Reconstruction is a New Frontier of Machine Learning
Wang, Ge,Ye, Jong Chu,Mueller, Klaus,Fessler, Jeffrey A. IEEE 2018 IEEE transactions on medical imaging Vol.37 No.6
<P>Over past several years, machine learning, or more generally artificial intelligence, has generated overwhelming research interest and attracted unprecedented public attention. As tomographic imaging researchers, we share the excitement from our imaging perspective [item 1) in the Appendix], and organized this special issue dedicated to the theme of “Machine learning for image reconstruction.” This special issue is a sister issue of the special issue published in May 2016 of this journal with the theme “Deep learning in medical imaging” [item 2) in the Appendix]. While the previous special issue targeted medical image processing/analysis, this special issue focuses on data-driven tomographic reconstruction. These two special issues are highly complementary, since image reconstruction and image analysis are two of the main pillars for medical imaging. Together we cover the whole workflow of medical imaging: from tomographic raw data/features to reconstructed images and then extracted diagnostic features/readings.</P>
Stimulated Release of Size‐Selected Cargos in Succession from Mesoporous Silica Nanoparticles
Wang, Cheng,Li, Zongxi,Cao, Dennis,Zhao, Yan‐,Li,Gaines, Justin W.,Bozdemir, O. Altan,Ambrogio, Michael W.,Frasconi, Marco,Botros, Youssry Y.,Zink, Jeffrey I.,Stoddart, J. Fraser WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.22
<P><B>Zwei Fliegen mit einer Klappe</B>: Die kovalente Bindung von β‐Cyclodextrin (gelb; siehe Bild) an mesoporöse Siliciumdioxid‐Nanopartikel (MSNs) ergibt ein duales Freisetzungssystem, das mit unterschiedlich großen Wirkstoffen (blaue und rote Kugeln) beladen werden kann, die sich auf verschiedene Stimuli hin nacheinander freisetzen lassen. Die kleineren Moleküle werden durch Absenken des pH‐Wertes freigesetzt, die größeren nach Abspaltung der Cyclodextrine von der MSN‐Oberfläche.</P>
정제명,왕순주,안무업,박재형,유기철,박준석,강재구,제프리 아놀드 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4
Background : To assess the current level of development of emergency medicine (EM) systems in Asia. Method : Survey of EM professionals from 12 Asian countries during a 90-day period from August to November 1998. 12 EM professionals from 12 Asian countries completed the survey. All participants were physicians. 7 participants (58%) gave presentations at an international EM conference during the study period. Respondents completed a 103 question questionnaire about the status of EM specialty, academic, patient care, information and management systems and the factors influencing the future of EM in their countries. Results : 92% of respondents stated that their countries have hospital-based emergency departments (ED). More than 80% of respondents reported that their countries have EMS systems and ED systems for trauma care and patient transfer. More than 70% stated that their countries have national EM organizations, EM research, national EMS activation phone numbers, ED systems for pediatric emergency care, emergency physician (EP) training in ACLS and ATLS and peer review. More than 60% reported official recognition of EM as an independent specialty status, ED triage systems and systems for customer service. More than 50% reported EM residency training programs, EM journals and EP ability to perform rapid sequence intubation (RSI). 50% reported EP ability to perform thrombolysis for acute MI and 33% reported EP ultrasonography. 92% felt that a lack of funding posed a moderate or great obstacle to the future development of EM in their countries. Conclusions : Many essential systems of EM now exist throughout Asia. In the systems of administration and emergency medical information in many countries, there are some parts to be developed further.