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RISS 인기검색어
- 검색키워드
- 저자 : Jeff C. John (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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The Role of Ribose on Oxidative Stress During Hypoxic Exercise: A Pilot Study
John G. Seifert,Andrew W. Subudhi,Min-Xin Fu,Karen L. Riska,Jeff C. John,Linda M. Shecterle,John A. St. Cyr 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O2 with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2±0.03nM/mg and 0.26±0.29μM, respectively) but were lower with ribose supplementation (0.04±0.03nM/mg and 0.38±0.29μM, respectively; P<.05). Uric acid levels were similar between groups (ribose vs. placebo, 4.55±0.06mg/dL vs. 4.67±0.06mg/dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
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The Role of Ribose on Oxidative Stress During Hypoxic Exercise: A Pilot Study
Seifert, John G.,Subudhi, Andrew W.,Fu, Min-Xin,Riska, Karen L.,John, Jeff C.,Shecterle, Linda M.,Cyr, John A. St. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% $O_2$ with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion ($0.2\;{\pm}\;0.03\;{\mu}M/mg$ and $0.26\;{\pm}\;0.29\;{\mu}M$, respectively) but were lower with ribose supplementation ($0.04\;{\pm}\;0.03\;{\mu}M/mg$ and $0.38\;{\pm}\;0.29\;{\mu}M$, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, $4.55\;{\pm}\;0.06\;mg/dL$ vs. $4.67\;{\pm}\;0.06\;mg/dL$). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
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