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송민유 ( Minyu Song ),서동균 ( Dong-kyun Suh ),천동원 ( Dong-won Cheon ),손지용 ( Jiyong Son ),박원서 ( Won Seo Park ),유자연 ( Jayeon Yoo ),함준상 ( Jun-sang Ham ) 한국유가공기술과학회 2017 Journal of Dairy Science and Biotechnology (JMSB) Vol.35 No.1
To gain insight on cheese consumption and develop strategies for the cheese industry, we conducted a survey of 742 women (age 25 or older) who were responsible for purchasing food for their families. Of them, 49.5% consumed cheese more than once a week and 25.1% expected that the cheese consumption of their families would increase, whereas only 7.1% expected a decrease in consumption. The most important considerations for purchasing cheese were taste and price. Of the respondents, 40.6% purchased domestic cheese, whereas 49.1% were unconcerned about the country of origin. Of them, 20.6% had experience of purchasing farm-made cheese, and 62.7% of them were satisfied with the cheese. These results suggest that cheese consumption will increase in the future, and that with attention to quality improvement and advertising, domestic farm-made cheese consumption could increase accordingly.
Joohyeong Lee,Eunmi Kim,Min-Kyung Kang,Jihye Ryu,Ji Eon Kim,Eun-Ae Shin,Yangie Pinanga,Kyung-hee Pyo,Haesong Lee,Eun Hae Lee,Heejin Cho,Jayeon Cheon,Wonsik Kim,Eek-hoon Jho,Semi Kim,Jung Weon Lee 생화학분자생물학회 2022 BMB Reports Vol.55 No.12
Mutation of the gene for adenomatous polyposis coli (APC), asseen in ApcMin/+ mice, leads to intestinal adenomas and carcinomasvia stabilization of β-catenin. Transmembrane 4 L sixfamily member 5 (TM4SF5) is involved in the development ofnon-alcoholic fatty liver disease, fibrosis, and cancer. However,the functional linkage between TM4SF5 and APC or β-cateninhas not been investigated for pathological outcomes. After interbreedingApcMin/+ with TM4SF5-overexpressing transgenic(TgTM4SF5) mice, we explored pathological outcomes in the intestinesand livers of the offspring. The intestines of 26-week-olddual-transgenic mice (ApcMin/+:TgTM4SF5) had intramucosal adenocarcinomasbeyond the single-crypt adenomas in ApcMin/+ mice. Additional TM4SF5 overexpression increased the stabilizationof β-catenin via reduced glycogen synthase kinase 3β (GSK3β)phosphorylation on Ser9. Additionally, the livers of the dualtransgenicmice showed distinct sinusoidal dilatation and featuresof hepatic portal hypertension associated with fibrosis,more than did the relatively normal livers in ApcMin/+ mice. Interestingly, TM4SF5 overexpression in the liver was positivelylinked to increased GSK3β phosphorylation (opposite to thatseen in the colon), β-catenin level, and extracellular matrix (ECM)protein expression, indicating fibrotic phenotypes. Consistentwith these results, 78-week-old TgTM4SF5 mice similarly had sinusoidaldilatation, immune cell infiltration, and fibrosis. Altogether,systemic overexpression of TM4SF5 aggravates pathologicalabnormalities in both the colon and the liver.